Ginseng-berry-mediated gold and silver nanoparticle synthesis and evaluation of their in vitro antioxidant, antimicrobial, and cytotoxicity effects on human dermal fibroblast and murine melanoma skin cell lines

Pérez, Zuly Elizabeth Jiménez; Mathiyalagan, Ramya; Markus, Josua; Kim, Yeon-Ju; Kang, Hyun Mi; Abbai, Ragavendran; Seo, Kwang; Wang, Dandan; Soshnikova, Veronika; Yang, Deok Chun

doi:10.2147/ijn.s118373

Cited by 94 publications

(50 citation statements)

References 37 publications

(35 reference statements)

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Section: Resultsmentioning

confidence: 99%

“…Green-synthesized AuNPs or AgNPs have been known to possess antioxidant activity in terms of DPPH radical scavenging activity [ 20 , 21 ]. Ginseng-berry-mediated AuNPs demonstrated antioxidant activity [ 20 ]. The absorption of phytochemicals in the ginseng berry extract on the surface of nanoparticles having a large surface area can be credited to the antioxidant activity of AuNPs [ 20 ].…”

Section: Resultsmentioning

confidence: 99%

“…Ginseng-berry-mediated AuNPs demonstrated antioxidant activity [ 20 ]. The absorption of phytochemicals in the ginseng berry extract on the surface of nanoparticles having a large surface area can be credited to the antioxidant activity of AuNPs [ 20 ]. Green-synthesized AuNPs using Angelica pubescens roots showed antioxidant activity with a dose-dependent manner [ 21 ].…”

Section: Resultsmentioning

confidence: 99%

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Antioxidant Potential of Artemisia capillaris, Portulaca oleracea, and Prunella vulgaris Extracts for Biofabrication of Gold Nanoparticles and Cytotoxicity Assessment

et al. 2018

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Three aqueous plant extracts (Artemisia capillaris, Portulaca oleracea, and Prunella vulgaris) were selected for the biofabrication of gold nanoparticles. The antioxidant activities (i.e., free radical scavenging activity, total phenolic content, and reducing power) of the extracts and how these activities affected the biofabrication of gold nanoparticles were investigated. P. vulgaris exerted the highest antioxidant activity, followed by A. capillaris and then P. oleracea. P. vulgaris was the most efficient reducing agent in the biofabrication process. Gold nanoparticles biofabricated by P. vulgaris (PV-AuNPs) had a maximum surface plasmon resonance of 530 nm with diverse shapes. High-resolution X-ray diffraction analysis showed that the PV-AuNPs had a face-centered cubic structure. The reaction yield was estimated to be 99.3% by inductively coupled plasma optical emission spectroscopy. The hydrodynamic size was determined to be 45 ± 2 nm with a zeta potential of − 13.99 mV. The PV-AuNPs exerted a dose-dependent antioxidant activity. Remarkably, the highest cytotoxicity of the PV-AuNPs was observed against human colorectal adenocarcinoma cells in the absence of fetal bovine serum, while for human pancreas ductal adenocarcinoma cells, the highest cytotoxicity was observed in the presence of fetal bovine serum. This result demonstrates that P. vulgaris extract was an efficient reducing agent for biofabrication of gold nanoparticles exerting cytotoxicity against cancer cells.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

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Antioxidant Potential of Artemisia capillaris, Portulaca oleracea, and Prunella vulgaris Extracts for Biofabrication of Gold Nanoparticles and Cytotoxicity Assessment

et al. 2018

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“…(C=O) groups, respectively [22]. The NFs and extract both showed absorption peaks at 2925.19 cm −1 , which indicated presence of an N-H (secondary amine) group [23].…”

Section: Ft-ir Analysismentioning

confidence: 95%

“…The SBT fruit extract showed an absorption peak at 899.71 cm −1 , which shifted to the ZnO/NF absorption peak at 1026.78 cm −1 , indicating a =CH-H (alkene) group. The extract showed an absorption peak at 1618.09 and 1718.33 cm −1 , which shifted to 1384.98 cm −1 and 1635.19 cm −1 , indicating alkene (C-H) and ketone (C=O) groups, respectively [22]. The NFs and extract both showed absorption peaks at 2925.19 cm −1 , which indicated presence of an N-H (secondary amine) group [23].…”

Section: Ft-ir Analysismentioning

confidence: 97%

Synthesis of a Zinc Oxide Nanoflower Photocatalyst from Sea Buckthorn Fruit for Degradation of Industrial Dyes in Wastewater Treatment

et al. 2019

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Green synthesis of ZnO nanoparticles has attracted research attention as a sustainable method of avoiding the destructive effect of chemicals. We synthesized a flower-shaped zinc oxide (ZnO) nanoflower (NF) from sea buckthorn fruit (SBT) by co-precipitation and characterized it using X-ray powder diffraction (XRD), X-ray photo electronic microscopy (XPS), photoluminescence (PL), field emission transmission electron microscopy (FE-TEM), and Fourier-transform infrared (FT-IR) spectroscopy. The ability of the ZnO/NF to degrade cationic and anionic dyes, including malachite green (MG), Congo red (CR), methylene blue (MB), and eosin Y (EY), under ultraviolet illumination was studied. The photocatalyst degraded approximately 99% of the MG, MB, CR and EY dyes within 70, 70, 80, and 90 min of contact time, respectively, at a dye concentration of 15 mg/L, 5 mg/L, SBT-ZnO/NF degraded 100% of the MG, MB, CR and EY dyes within 23, 25, 28, and 30 min, respectively. The results indicate that SBT-ZnO/NFs as synthesized is an inexpensive, non-toxic, rapid, and reusable photocatalyst that can play an enhanced role in wastewater treatment.

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Plant‐Derived Vesicle‐Like Nanoparticles as Promising Biotherapeutic Tools: Present and Future

et al. 2023

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At present, it is generally acknowledged that EVs are secreted by almost all living cells including plant cells. [4] Compared with mammalian EVs, the research of plant EVs is still in its infancy. Increasing evidence has proved that plant cells are able to secret exosome-like vesicles or extracellular vesicles into apoplast space. [5] In the 1960s, using transmission electron microscopy (TEM), Halperin et al. for the first time observed and discovered multivesicular bodies (MVBs) fusing with the plasma membrane and releasing exosome-like vesicles into the cell wall area in carrot cell cultures. [6] Fifty years after this first discovery, Regenteet al. used a tissue-infiltration-centrifugation method and successfully separated exosome-like vesicles from apoplast washing fluids (AWF) of sunflower seeds. [5a] Following these discoveries, plant exosomelike vesicles or vesicle-like nanoparticles have been successfully isolated from many plant species, including ginseng, ginger, broccoli, bitter melon, oat, grape, grapefruit, lemon, blueberry, orange, sunflower seed, and Arabidopsis, etc. [5a,7] The efficient separation of PDVLNs from plant cells is still one of the challenges that need to be solved in the plant EV field. At present, two plant tissue pre-processing methods, namely tissue-disruption and tissue-infiltration centrifugation, have emerged as favorite methods used for vesicle separation from plant cells in the field. [5b,8] After tissue pre-treatment, most studies use ultracentrifugation or density gradient centrifugation for further PDVLN separation. [5a,9] In addition, novel separation methods are under development for PDVLNs, such as ultrafiltration, immunoaffinity capture, size-exclusive chromatography, etc. [5b,7j,10] However, it is still challenging to isolate specific PDVLN subtypes, due to the lack of generic or specific markers for PDVLNs and well-verified plant species antibodies. [4b,5b] The nomenclature of vesicles prepared by these methods is not standardized in existing references. Many terms were used, including "plant particles", "plant vesicles", etc. [7b,8b,10,11] To facilitate communication in the plant vesicle field, standardizing the nomenclatures is necessary. We thus propose to unify these nomenclatures into plant-derived vesicle-like nanoparticles (PDVLNs) in this review.PDVLNs share many similar physical characteristics to those of human-derived EVs, including features such as morphology, particle size, concentration, Zeta potential, etc. [2a,7b,e,11] To further elucidate the specific molecular mechanism of PDVLNs on Extracellular vesicles (EVs) are heterogeneous, phospholipid bilayer-enclosed biological particles that regulate cell communication by molecular cargo delivery and surface signaling. EVs are secreted by almost all living cells, including plant cells. Plant-derived vesicle-like nanoparticles (PDVLNs) is a generic term referring to vesicle-like nanostructure particles isolated from plants. Their low immunogenicity and wide availability make PDVLNs safer and mor...

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Ginseng-berry-mediated gold and silver nanoparticle synthesis and evaluation of their in vitro antioxidant, antimicrobial, and cytotoxicity effects on human dermal fibroblast and murine melanoma skin cell lines

Cited by 94 publications

References 37 publications

Antioxidant Potential of Artemisia capillaris, Portulaca oleracea, and Prunella vulgaris Extracts for Biofabrication of Gold Nanoparticles and Cytotoxicity Assessment

Antioxidant Potential of Artemisia capillaris, Portulaca oleracea, and Prunella vulgaris Extracts for Biofabrication of Gold Nanoparticles and Cytotoxicity Assessment

Synthesis of a Zinc Oxide Nanoflower Photocatalyst from Sea Buckthorn Fruit for Degradation of Industrial Dyes in Wastewater Treatment

Plant‐Derived Vesicle‐Like Nanoparticles as Promising Biotherapeutic Tools: Present and Future

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