Ginseng, the natural effectual antiviral: Protective effects of Korean Red Ginseng against viral infection

Im, Kyungtaek; Kim, Jisu; Min, Hye‐Young

doi:10.1016/j.jgr.2015.09.002

Cited by 99 publications

(73 citation statements)

References 86 publications

(99 reference statements)

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“…Herbal and Chinese medicines have also been shown to help in the treatment of viral diseases. For instance, ginseng root is useful in the prevention of viral respiratory diseases such as those due to strains of influenza [19,20]. Astragulus membranaceus is used to treat common cold and upper respiratory infections [21], whereas Pelargonium sidoides is an effective herbal remedy for the inhibition of respiratory viruses' replication [20].…”

Section: The Role Of Bioactive Ingredients In Supporting the Human Immentioning

confidence: 99%

The Food Systems in the Era of the Coronavirus (COVID-19) Pandemic Crisis

Galanakis

2020

Foods

776

636

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The World Health Organization (WHO) declared the outbreak of coronavirus disease (COVID-19, broadly referred to as "coronavirus") a global pandemic, while thousands of infections and deaths are reported daily. The current article explores the food systems in the era of the COVID-19 pandemic crisis. It provides insights about the properties of bioactive ingredients of foods and herbs for the support of the human immune system against infections before discussing the possibility of COVID-19 transmission through the food chain. It also highlights the global food security issues arising from the fact that one-third of the world's population is on lockdown. Finally, it underlines the importance of sustainability in the food chain in order to avoid or reduce the frequency of relevant food and health crises in the future.

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Section: The Role Of Bioactive Ingredients In Supporting the Human Immentioning

confidence: 99%

The Food Systems in the Era of the Coronavirus (COVID-19) Pandemic Crisis

Galanakis

2020

Foods

776

636

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“…CAST-P server also revealed the presence of PHE138 as active site residue of cavity 3 in Mpro protein (Table 1). Several compounds, such as flavonoids, terpenoids and phenolics from essential oils, have been reported to show antiviral bioactivities [Im et al, 2015;Zakarayan et al, 2017]. We investigated that jensenone as potential inhibitor of the COVID-19 Mpro.…”

Section: Resultsmentioning

confidence: 99%

Eucalyptol (1,8 cineole) from Eucalyptus Essential Oil a Potential Inhibitor of COVID 19 Corona Virus Infection by Molecular Docking Studies<strong> </strong>

Ad¹,

Kaur²

2020

Preprint

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COVID-19, a member of corona virus family is spreading its tentacles across the world due to lack of drugs at present. However, the main viral proteinase (Mpro/3CLpro) has recently been regarded as a suitable target for drug design against SARS infection due to its vital role in polyproteins processing necessary for coronavirus reproduction. The present in silico study was designed to evaluate the effect of Jensenone, a essential oil component from eucalyptus oil, on Mpro by docking study. In the present study, molecular docking studies were conducted by using 1-click dock and swiss dock tools. Protein interaction mode was calculated by Protein Interactions Calculator.The calculated parameters such as binding energy, and binding site similarity indicated effective binding of Jensenone to COVID-19 proteinase. Active site prediction further validated the role of active site residues in ligand binding. PIC results indicated that, Mpro/ Jensenone complexes forms hydrophobic interactions, hydrogen bond interactions and strong ionic interactions. Therefore, Jensenone may represent potential treatment potential to act as COVID-19 Mpro inhibitor. However, further research is necessary to investigate their potential medicinal use.

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“…This technology has been implemented for the production of ginsenosides with yield of 268 mg/kg (Lee et al, 2010). Previously, the anti-HIV effect of ginsenosides alone or in combination with zidovudine monotherapy or HAART therapy has been demonstrated (Im et al, 2016). Beside these advances, progress in genome manipulation resulted in relatively large quantities of pharmaceuticals.…”

Section: Search For Plants With Both Anti-tb and Anti-hiv Activitymentioning

confidence: 99%

The potential of plant systems to break the HIV‐TB link

Habibi

Daniell

Soccol

et al. 2019

Plant Biotechnology Journal

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Summary Tuberculosis (TB) and human immunodeficiency virus (HIV) can place a major burden on healthcare systems and constitute the main challenges of diagnostic and therapeutic programmes. Infection with HIV is the most common cause of Mycobacterium tuberculosis (Mtb), which can accelerate the risk of latent TB reactivation by 20‐fold. Similarly, TB is considered the most relevant factor predisposing individuals to HIV infection. Thus, both pathogens can augment one another in a synergetic manner, accelerating the failure of immunological functions and resulting in subsequent death in the absence of treatment. Synergistic approaches involving the treatment of HIV as a tool to combat TB and vice versa are thus required in regions with a high burden of HIV and TB infection. In this context, plant systems are considered a promising approach for combatting HIV and TB in a resource‐limited setting because plant‐made drugs can be produced efficiently and inexpensively in developing countries and could be shared by the available agricultural infrastructure without the expensive requirement needed for cold chain storage and transportation. Moreover, the use of natural products from medicinal plants can eliminate the concerns associated with antiretroviral therapy (ART) and anti‐TB therapy (ATT), including drug interactions, drug‐related toxicity and multidrug resistance. In this review, we highlight the potential of plant system as a promising approach for the production of relevant pharmaceuticals for HIV and TB treatment. However, in the cases of HIV and TB, none of the plant‐made pharmaceuticals have been approved for clinical use. Limitations in reaching these goals are discussed.

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Ginseng, the natural effectual antiviral: Protective effects of Korean Red Ginseng against viral infection

Cited by 99 publications

References 86 publications

The Food Systems in the Era of the Coronavirus (COVID-19) Pandemic Crisis

The Food Systems in the Era of the Coronavirus (COVID-19) Pandemic Crisis

Eucalyptol (1,8 cineole) from Eucalyptus Essential Oil a Potential Inhibitor of COVID 19 Corona Virus Infection by Molecular Docking Studies<strong> </strong>

The potential of plant systems to break the HIV‐TB link

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