Ginsenoside 20(S)-protopanaxadiol induces cell death in human endometrial cancer cells via apoptosis

The anti-tumor efficacy of 20(S)-protopanaxadiol, an active metabolite of ginseng, according to fasting on hepatocellular carcinoma

“…20(S)-protopanaxadiol (20(S)-PPD), a derivative of ginsenosides, is the final form of protopanaxadiol saponins metabolized by human intestinal microflora. 20(S)-PPD performs many biological functions, including differentiation regulation of neural stem cells and anti-inflammatory properties [ [15] , [16] , [17] ]. The major novel findings in the present study were that 20(S)-PPD performed a role in a variety of tumor inhibition.…”

Wound Healing Effect of Gintonin Involves Lysophosphatidic Acid Receptor/Vascular Endothelial Growth Factor Signaling Pathway in Keratinocytes

“…Ginseng is a traditional herbal medicine that has been used as a tonic for thousands of years. Substantial scientific research has shown that ginseng and its components exert various pharmacological activities, including anti-cancer, anti-diabetes, anti-oxidant, anti-inflammatory, immune system-improving, and central nervous system-improving effects [ 1 , 2 , 3 , 4 , 5 , 6 , 7 , 8 ]. Korean ginseng, a root of Panax ginseng C.A.…”

Phytochemicals in Gynecological Cancer Prevention

“…One of them was a clinical control study by Ricceri et al in which the authors showed that higher vegetable consumption, following the Mediterranean diet, which has a low content of pro-inflammatory compounds which is associated with a lower risk of developing endometrial cancer (respectively: OR fifth quintile vs. first quintile = 0. [151]. Despite the promising results of experimental studies, more research is still necessary, especially on the epidemiological type, which would verify the presented results and assess their possible chemopreventive effects on endometrial cancer.…”

“…Another example is ginsenosides [ 150 ], which are found in ginseng root (Panax ginseng C. A. Meyer). Jo et al have shown in vitro on the cell line (HEC)-1A that 20(S)-protopanaxadiol (one of the ginsenosides) leads to the death of endometrial cancer cells by the induction of apoptosis [ 151 ]. Despite the promising results of experimental studies, more research is still necessary, especially on the epidemiological type, which would verify the presented results and assess their possible chemopreventive effects on endometrial cancer.…”