2022
DOI: 10.1016/j.bbrc.2021.12.071
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Ginsenoside compound K acts via LRP1 to alleviate Amyloid β42-induced neuroinflammation in microglia by suppressing NF-κB

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Cited by 17 publications
(14 citation statements)
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“…40) As NF-κB is a key M1 macrophage transcription factor required for inducing genes encoding IL-6, activating NF-κB in macrophages is directly related to IL-6 production. 41) Several studies have illustrated that the active components of the HET formulation [42][43][44][45][46][47][48][49][50][51] contribute to the inhibition of NF-κB activation. Although the elevation of serum IL-6 has been observed in patients with HCC who had received lenvatinib treatment, 52) it has never been reported in animals without tumors during the lenvatinib trearment.…”
Section: Discussionmentioning
confidence: 99%
“…40) As NF-κB is a key M1 macrophage transcription factor required for inducing genes encoding IL-6, activating NF-κB in macrophages is directly related to IL-6 production. 41) Several studies have illustrated that the active components of the HET formulation [42][43][44][45][46][47][48][49][50][51] contribute to the inhibition of NF-κB activation. Although the elevation of serum IL-6 has been observed in patients with HCC who had received lenvatinib treatment, 52) it has never been reported in animals without tumors during the lenvatinib trearment.…”
Section: Discussionmentioning
confidence: 99%
“…The overactivation of NF-κB promoted microglia into an inflammatory state, increased the diffusion of tau protein, and reduced spatial memory in AD mice [ 211 ]. It was confirmed that ginsenoside compound K can inhibit NF-κB p65 nuclear translocation in Aβ42 oligomers-induced BV2 cells [ 212 ]. NF-κB can further activate the NLRP3 inflammasome, a proteolytic complex present in various mammalian cells, which comprises the NLRP3 protein, the adaptor apoptosis-associated speck-like protein, and pro-caspase-1 [ 213 ].…”
Section: Signaling Pathways Involved In the Treatment Of CI By Ginsen...mentioning
confidence: 98%
“…It can also be used to treat severe vascular inflammatory diseases, such as systemic inflammatory response syndrome and septic shock [22] . Jiao and Jia [23] used ginsenoside compound K (GCK) for amyloid protein β‐42‐induced microglial neuroinflammation. It was found that GCK can inhibit NF‐κB p65 nuclear translocation, increase the expression of LRP1, inhibit the release of proinflammatory cytokines, and improve neuroinflammation caused by microglia.…”
Section: The Active Ingredient In Black Ginseng and Anti‐inflammatory...mentioning
confidence: 99%