Ginsenoside compound K increases glucagon-like peptide-1 release and L-cell abundance in db/db mice through TGR5/YAP signaling

Tian, Fengyuan; Xu, Wangda; Chen, Lan; Chen, Tianxi; Feng, Xiaohong; Chen, Jie; Wei, Danning; Huang, Qi

doi:10.1016/j.intimp.2022.109405

Cited by 11 publications

(12 citation statements)

References 49 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Previous studies have shown CK yields renoprotective effects in a dose-dependent manner, with the most significant improvements observed at a dosage of 40 mg/kg, alongside its anti-inflammatory actions [ 25 ]. This aligns with our earlier research highlighting consistent anti-inflammatory potential at the same dosage [ 19 ]. Accordingly, investigating the role of CK in LN from a podocyte perspective is valuable beyond the context of inflammation resolution.…”

Section: Discussionsupporting

confidence: 93%

“…In the present study, CK demonstrated the potential to restrict motility and promote podocyte attachment. Additionally, our previous works have confirmed that CK could normalize the assembled state of the cytoskeleton [ 19 , 47 ]. Thus, CK might counteract cytoskeleton disruption in podocytes, leading to the preservation of foot process interdigitation.…”

Section: Discussionmentioning

confidence: 71%

“…CK (molecular weight 622.87 Da, purity ≥99.0 %) was purchased from Shanghai Winherb Medical Science Co., Ltd. (Shanghai, China). In the CK group, mice received intragastric administration of CK (40 mg/kg) dissolved in 0.5 % CMC-Na once daily, following the previously outlined dosage protocol [ 19 , 25 ]. The remaining mice were given an equivalent volume of CMC-Na.…”

Section: Methodsmentioning

confidence: 99%

“…Ginsenoside Compound K (CK, 20-O-b-D-glucopyranosyl20(S)-protopanaxadiol ), an absorbable bioavailable component of ginseng, derives from ginsenosides Rb1, Rb2, Rc, and Rd through gut microbiota-driven biotransformation [ 18 ]. Numerous reports indicated that CK confers reliable metabolic benefits with increased phosphorylation of AMPK, leaning on its potent anti-inflammatory properties [ [19] , [20] , [21] , [22] ]. Prior studies revealed that CK suppresses NLRP3 inflammasome activation via autophagy modulation coupled with Th cell modulation in NZB/WF1 mice [ 23 ].…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Reciprocal regulation of SIRT1 and AMPK by Ginsenoside compound K impedes the conversion from plasma cells to mitigate for podocyte injury in MRL/lpr mice in a B cell-specific manner

Song,

Jin,

Wang

et al. 2024

Journal of Ginseng Research

Self Cite

View full text Add to dashboard Cite

Section: Discussionsupporting

confidence: 93%

Section: Discussionmentioning

confidence: 71%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Reciprocal regulation of SIRT1 and AMPK by Ginsenoside compound K impedes the conversion from plasma cells to mitigate for podocyte injury in MRL/lpr mice in a B cell-specific manner

Song,

Jin,

Wang

et al. 2024

Journal of Ginseng Research

Self Cite

View full text Add to dashboard Cite

“…CK has gained attention recently because of its antioxidant [ 9 ], anti-inflammatory [ 5 , 10 ], and anti-cancer properties [ 11 ]. The efficacy of CK has been extended to inhibit palmitate-induced skeletal muscle apoptosis by repressing endoplasmic reticulum stress [ 12 ] and to stimulate the secretion of glucagon-like peptide-1 (GLP1), a gastrointestinal hormone to ameliorate impaired glucose tolerance in type 2 diabetes db/db mice [ 13 ].…”

Section: Introductionmentioning

confidence: 99%

Inhibitory Effects of Ginsenoside Compound K on Lipopolysaccharide-Stimulated Inflammatory Responses in Macrophages by Regulating Sirtuin 1 and Histone Deacetylase 4

et al. 2023

View full text Add to dashboard Cite

Inflammation, an innate immune response mediated by macrophages, has been a hallmark leading to the pathophysiology of diseases. In this study, we examined the inhibitory effects of ginsenoside compound K (CK) on lipopolysaccharide (LPS)-induced inflammation and metabolic alteration in RAW 264.7 macrophages by regulating sirtuin 1 (SIRT1) and histone deacetylase 4 (HDAC4). LPS suppressed SIRT1 while promoting HDAC4 expression, accompanied by increases in cellular reactive oxygen species accumulation and pro-inflammatory gene expression; however, the addition of CK elicited the opposite effects. CK ameliorated the LPS-induced increase in glycolytic genes and abrogated the LPS-altered genes engaged in the NAD+ salvage pathway. LPS decreased basal, maximal, and non-mitochondrial respiration, reducing ATP production and proton leak in macrophages, which were abolished by CK. SIRT1 inhibition augmented Hdac4 expression along with increased LPS-induced inflammatory and glycolytic gene expression, while decreasing genes that regulate mitochondrial biogenesis; however, its activation resulted in the opposite effects. Inhibition of HDAC4 enhanced Sirt1 expression and attenuated the LPS-induced inflammatory gene expression. In conclusion, CK exerted anti-inflammatory and antioxidant properties with the potential to counteract the alterations of energy metabolism, including glycolysis and mitochondrial respiration, through activating SIRT1 and repressing HDAC4 in LPS-stimulated macrophages.

show abstract

Saponin monomers: Potential candidates for the treatment of type 2 diabetes mellitus and its complications

Zhang,

He,

Liu

et al. 2024

Phytotherapy Research

View full text Add to dashboard Cite

Type 2 diabetes mellitus (T2DM), a metabolic disease with persistent hyperglycemia primarily caused by insulin resistance (IR), has become one of the most serious health challenges of the 21st century, with considerable economic and societal implications worldwide. Considering the inevitable side effects of conventional antidiabetic drugs, natural ingredients exhibit promising therapeutic efficacy and can serve as safer and more cost‐effective alternatives for the management of T2DM. Saponins are a structurally diverse class of amphiphilic compounds widely distributed in many popular herbal medicinal plants, some animals, and marine organisms. There are many saponin monomers, such as ginsenoside compound K, ginsenoside Rb1, ginsenoside Rg1, astragaloside IV, glycyrrhizin, and diosgenin, showing great efficacy in the treatment of T2DM and its complications in vivo and in vitro. However, although the mechanisms of action of saponin monomers at the animal and cell levels have been gradually elucidated, there is a lack of clinical data, which hinders the development of saponin‐based antidiabetic drugs. Herein, the main factors/pathways associated with T2DM and the comprehensive underlying mechanisms and potential applications of these saponin monomers in the management of T2DM and its complications are reviewed and discussed, aiming to provide fundamental data for future high‐quality clinical studies and trials.

show abstract

Ginsenoside compound K increases glucagon-like peptide-1 release and L-cell abundance in db/db mice through TGR5/YAP signaling

Cited by 11 publications

References 49 publications

Reciprocal regulation of SIRT1 and AMPK by Ginsenoside compound K impedes the conversion from plasma cells to mitigate for podocyte injury in MRL/lpr mice in a B cell-specific manner

Reciprocal regulation of SIRT1 and AMPK by Ginsenoside compound K impedes the conversion from plasma cells to mitigate for podocyte injury in MRL/lpr mice in a B cell-specific manner

Inhibitory Effects of Ginsenoside Compound K on Lipopolysaccharide-Stimulated Inflammatory Responses in Macrophages by Regulating Sirtuin 1 and Histone Deacetylase 4

Saponin monomers: Potential candidates for the treatment of type 2 diabetes mellitus and its complications

Contact Info

Product

Resources

About