Ginsenoside F1 administration promotes UCP1-dependent fat browning and ameliorates obesity-associated insulin resistance

Meng, Yuguang; Li, Weili; Hu, Chenxing; Chen, Si; Li, Haiyang; Bai, Feifei; Zheng, Lujuan; Yuan, Ye; Fan, Yuying; Zhou, Yifa

doi:10.1016/j.fshw.2023.03.025

Cited by 9 publications

(2 citation statements)

References 30 publications

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“…However, in this study, both active and inactivated L. plantarum L. plantarum K8 also decrease adipose in weight and size (Lim et al, 2022). UCP1 has been shown to regulate extracellular succinate and liver inflammation by increasing energy expenditure and reducing liver lipids (Meng et al, 2023). The experimental results of immunohistochemical staining showed that J26P increased the expression of UCP1 in the liver.…”

Section: Discussionmentioning

confidence: 54%

Lactobacillus plantarum J26 postbiotics alleviate high‐fat and high‐cholesterol diet‐induced hypercholesterolemia via regulating the LXRα‐CYP7A1‐bile acid‐excretion pathway

Zheng,

Ma,

Wang

et al. 2023

Food Frontiers

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Postbiotics have received increasing interest for their storage stability and safety compared to probiotics, as well as their potential functionality. In this study, edible Lactobacillus plantarum J26 postbiotics (J26P) were prepared by spray drying using skimmed milk as the medium, and 1113 compounds were identified. The aim of this study was to evaluate the cholesterol lowering effect of J26P on hypercholesterolemic mice induced by a high‐fat and high‐cholesterol diet (HCD). The results suggest that J26P significantly alleviated weight gain and appetite reduction in HCD mice. J26P also improved serum and liver biochemical parameters at various levels, including lower total cholesterol (TC), triglyceride (TG), low‐density lipoprotein cholesterol (LDL‐C) in the serum, and TC, TG, LDL‐C, glutamic oxaloacetic transaminase, and glutamic‐pyruvic transaminase in the liver, and increase high‐density lipoprotein cholesterol in the serum and liver. Moreover, liver histopathologic examinations revealed that J26P significantly inhibited fat accumulation and degeneration in hypercholesterolemic mice and increased the expression of liver uncoupling protein 1. Furthermore, the J26P intervention effectively promoted the reduction of cholesterol levels in hypercholesterolemic mice via the LXRα‐CYP7A1‐bile acid‐excretion pathway, which was corroborated by the increased fecal total cholesterol and fecal total bile acid levels. This work provided a theoretical basis for the industrial development of postbiotics and the alleviation of hypercholesterolemia and its complications.

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Section: Discussionmentioning

confidence: 54%

Lactobacillus plantarum J26 postbiotics alleviate high‐fat and high‐cholesterol diet‐induced hypercholesterolemia via regulating the LXRα‐CYP7A1‐bile acid‐excretion pathway

Zheng,

Ma,

Wang

et al. 2023

Food Frontiers

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“…This is because hypertrophy triggers the development of severe metabolic diseases [21]. Improving adipose tissue heat production is effective in improving obesity-induced insulin resistance [34]. DAG has been found to significantly regulate mitochondrial metabolic thermogenesis [35].…”

Section: Discussionmentioning

confidence: 99%

The Lipid-Metabolism-Associated Anti-Obesity Properties of Rapeseed Diacylglycerol Oil

Mao,

Zheng,

et al. 2024

Nutrients

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To investigate the effects of rapeseed diacylglycerol oil (RDG) intake on lipid accumulation and metabolism in C57BL/6J mice, obese mice were fed a high-fat diet in which 45% of the total energy content came from RDG (RDGM group) or rapeseed triacylglycerol oil (RTGM group). This diet intervention was conducted for 12 weeks following the establishment of the obese mouse model. By the end of the experiment, the serum glucose levels of the mice in the RTGM and RDGM groups were 13.0 ± 1.3 mmol/L and 9.7 ± 1.5 mmol/L, respectively. Meanwhile, the serum triglyceride level in the RDGM group was 26.3% lower than that in the RTGM group. The weight-loss effect in the RDGM group was accompanied by a significant decrease in the white adipose tissue (WAT) index. The RDG intervention did not significantly change the antioxidant and anti-inflammatory properties of the rapeseed oil in vivo. The RDG diet improved the liver lipid metabolism abnormalities induced by a high-fat diet, leading to decreased liver damage index values (AST and ALT). Additionally, compared to that in the RTGM group, the expression of the adipogenic genes PPAR-γ and DGAT decreased in both the liver and intestine by 21.7% and 16.7% and by 38.7% and 47.2%, respectively, in the RDGM group. Further, most lipolytic genes in BAT showed no significant change after the RDG intervention. This implies that RDG regulates lipid metabolism by altering the expression of adipogenic genes in the liver, intestine, and adipose tissue, thereby reducing the accumulation of WAT. Furthermore, the RDG diet enhanced gut flora diversity, increasing the relative levels of unclassified Muribaculaceae and decreasing the levels of Dubosiella and Faecalibaculum in the mouse gut, potentially accelerating lipid metabolism. Thus, a three-month RDG diet intervention in obese mice exhibited benefits in regulating the somatotype, serum obesity-related indices, gut flora structure, and lipid metabolism in the adipose tissue, liver, and intestine.

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Recent trends in ginseng research

Ito,

Ito

2024

J Nat Med

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Ginsenoside F1 administration promotes UCP1-dependent fat browning and ameliorates obesity-associated insulin resistance

Cited by 9 publications

References 30 publications

Lactobacillus plantarum J26 postbiotics alleviate high‐fat and high‐cholesterol diet‐induced hypercholesterolemia via regulating the LXRα‐CYP7A1‐bile acid‐excretion pathway

Lactobacillus plantarum J26 postbiotics alleviate high‐fat and high‐cholesterol diet‐induced hypercholesterolemia via regulating the LXRα‐CYP7A1‐bile acid‐excretion pathway

The Lipid-Metabolism-Associated Anti-Obesity Properties of Rapeseed Diacylglycerol Oil

Recent trends in ginseng research

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