Ginsenoside F4 Alleviates Skeletal Muscle Insulin Resistance by Regulating PTP1B in Type II Diabetes Mellitus

Zhao, Yujie; Liu, Yao; Deng, Jianjun; Zhu, Chenhui; Ma, Xiaoxuan; Jiang, Min; Fan, Daidi

doi:10.1021/acs.jafc.3c01262

Cited by 9 publications

(2 citation statements)

References 39 publications

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“…The inhibition of this enzyme by GF4 resulted in increased insulin receptor and insulin receptor substrate 1 tyrosine phosphorylation and enhanced insulin sensitivity. Overall, GF4 activates the insulin signaling pathway by inhibiting PTP1B [41]. Further, GF4 has an inhibitory effect on human lymphocytoma Jurkat (JK) cell by inducing apoptosis [42].…”

Section: Ginsenoside F4 (Gf4)mentioning

confidence: 99%

Therapeutic Applications of Ginseng Natural Compounds for Health Management

Ahmad,

Hwang

et al. 2023

IJMS

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Ginseng is usually consumed as a daily food supplement to improve health and has been shown to benefit skeletal muscle, improve glucose metabolism, and ameliorate muscle-wasting conditions, cardiovascular diseases, stroke, and the effects of aging and cancers. Ginseng has also been reported to help maintain bone strength and liver (digestion, metabolism, detoxification, and protein synthesis) and kidney functions. In addition, ginseng is often used to treat age-associated neurodegenerative disorders, and ginseng and ginseng-derived natural products are popular natural remedies for diseases such as diabetes, obesity, oxidative stress, and inflammation, as well as fungal, bacterial, and viral infections. Ginseng is a well-known herbal medication, known to alleviate the actions of several cytokines. The article concludes with future directions and significant application of ginseng compounds for researchers in understanding the promising role of ginseng in the treatment of several diseases. Overall, this study was undertaken to highlight the broad-spectrum therapeutic applications of ginseng compounds for health management.

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Section: Ginsenoside F4 (Gf4)mentioning

confidence: 99%

Therapeutic Applications of Ginseng Natural Compounds for Health Management

Ahmad,

Hwang

et al. 2023

IJMS

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“…CHM may improve serum glucose regulation ( Yang et al, 2023 ). For example, ginseng was shown to positively impact glucose metabolism, reduce insulin resistance, and increase energy expenditure ( Zhao et al, 2023 ).Cinnamon was found to have anti-inflammatory effects and the ability to lower fasting blood sugar levels ( Liu et al, 2023a ). A CHM formula is made of multiple botanical drugs with specific properties that, when combined, may enhance the overall therapeutic effects ( Lee et al, 2022 ).…”

Section: Introductionmentioning

confidence: 99%

The reporting quality of randomized controlled trials in Chinese herbal medicine (CHM) formulas for diabetes based on the consort statement and its extension for CHM formulas

Liu,

Hu,

Zhou

et al. 2024

Front. Pharmacol.

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Background: This study aimed to assess the overall reporting quality of randomized controlled trials (RCTs) in Chinese herbal medicine (CHM) formulas for patients with diabetes, and to identify factors associated with better reporting quality.Methods: Four databases including PubMed, Embase, Cochrane Library and Web of Science were systematically searched from their inception to December 2022. The reporting quality was assessed based on the Consolidated Standards of Reporting Trials (CONSORT) statement and its CHM formula extension. The overall CONSORT and its CHM formula extension scores were calculated and expressed as proportions separately. We also analyzed the pre-specified study characteristics and performed exploratory regressions to determine their associations with the reporting quality.Results: Seventy-two RCTs were included. Overall reporting quality (mean adherence) were 53.56% and 45.71% on the CONSORT statement and its CHM formula extension, respectively. The strongest associations with reporting quality based on the CONSORT statement were multiple centers and larger author numbers. Compliance with the CHM formula extension, particularly regarding the disclosure of the targeted traditional Chinese medicine (TCM) pattern (s), was generally insufficient.Conclusion: The reporting quality of RCTs in CHM formulas for diabetes remains unsatisfactory, and the adherence to the CHM formula extension is even poorer. In order to ensure transparent and standardized reporting of RCTs, it is essential to advocate for or even mandate adherence of the CONSORT statement and its CHM formula extension when reporting trials in CHM formulas for diabetes by both authors and editors.

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Effects of steaming process on rare saponins and efficacy of Panax ginseng, Panax notoginseng and Panax quinquefolium

Zhao,

Han,

et al. 2024

Chinese Herbal Medicines

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Ginsenoside F4 Alleviates Skeletal Muscle Insulin Resistance by Regulating PTP1B in Type II Diabetes Mellitus

Cited by 9 publications

References 39 publications

Therapeutic Applications of Ginseng Natural Compounds for Health Management

Therapeutic Applications of Ginseng Natural Compounds for Health Management

The reporting quality of randomized controlled trials in Chinese herbal medicine (CHM) formulas for diabetes based on the consort statement and its extension for CHM formulas

Effects of steaming process on rare saponins and efficacy of Panax ginseng, Panax notoginseng and Panax quinquefolium

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