Ginsenoside modified lipid-coated perfluorocarbon nanodroplets: A novel approach to reduce complement protein adsorption and prolong in vivo circulation

Triterpene-Based Prodrug for Self-Boosted Drug Release and Targeted Oral Squamous Cell Carcinoma Chemotherapy

“…31,32 Nowadays, researchers also focus on their similar steroid structure to cholesterol for lipid nanoparticle (NP) construction and their active targeting ligands on glucose transporters (GLUTs) for novel targeted chemotherapeutic design. 33,34 Herein, a promising targeted stimuli-responsive prodrug platform was proposed to exert significant therapeutic effects by dual-induced apoptosis against OSCC based on rapid solvent-exchange coassembly of triterpene compounds (Scheme 1). By bridging two GA molecules with a thioketal linker, 35 a reactive oxygen species (ROS)-responsive dimeric molecule (TK-GA 2 ) was designed and synthesized.…”

“…Glycyrrhetinic acid (GA), a pentacyclic triterpenoid aglycone component of glycyrrhizic acid isolated from licorice, is commonly used for treating various tumors and viral infections. , The targets and mechanisms of pro-apoptosis of GA have been studied over the past decades. − However, the cytotoxicity of GA against OSCC has not yet been investigated in detail. Meantime, how to improve the dissolution of GA effectively also benefits the biomedical application of GA. , Ginsenosides (such as Rb1, Rh2, Rg3, Rg5, Re, and Rf) isolated from ginseng, another kind of triterpenoids, were widely used as chemotherapeutics for antitumor research. , Nowadays, researchers also focus on their similar steroid structure to cholesterol for lipid nanoparticle (NP) construction and their active targeting ligands on glucose transporters (GLUTs) for novel targeted chemotherapeutic design. , …”