Ginsenoside Rb1 promotes browning through regulation of PPARγ in 3T3-L1 adipocytes

Mu, Qianqian; Fang, Xin; Li, Xiaoke; Zhao, Dandan; Mo, Fangfang; Jiang, Guiyan; Yu, Na; Zhang, Yi; Guo, Yubo; Fu, Min; Liu, Jun Li; Zhang, Dongwei; S, Gao

doi:10.1016/j.bbrc.2015.09.064

Cited by 96 publications

(65 citation statements)

References 32 publications

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“…Recently, it is reported that berberine induced the development of brown-like adipocytes in inguinal, but not in epididymal adipose depots 30 . Ginsenoside Rb1 promotes browning in 3T3-L1 adipocytes 31 . Here, we reported that cinnamon induced browning in the subcutaneous adipocytes of the obesity mouse models.…”

Section: Discussionmentioning

confidence: 99%

Cinnamon induces browning in subcutaneous adipocytes

Kwan

et al. 2017

Sci Rep

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Browning is the process of increasing the number of brite cells, which helps to increase energy expenditure and reduce obesity. Consumption of natural and non-toxic herbal extracts that possess the browning effect is an attractive anti-obesity strategy. In this study, we examined the browning effect of cinnamon extract. We found that cinnamon extract (CE) induced typical brown adipocyte multiocular phenotype in 3T3-L1 adipocytes. The treatment also increased brown adipocytes markers and reduced white adipocytes markers in the 3T3-L1 adipocytes. In ex vivo studies, we found that CE increased brown adipocytes markers in the subcutaneous adipocytes isolated from db/db mice and diet-induced obesity (DIO) mice. However, CE did not significantly affect UCP1 expression in the adipocytes isolated from perinephric adipose tissue and epididymal adipose tissue. β3-adernergic receptor (β3-AR) antagonist reduced the CE-enhanced UCP1 expression, suggesting an involvement of the β3-AR activity. Oral administration of CE significantly increased UCP1 expression in the subcutaneous adipose tissue in vivo and reduced the body weight of the DIO mice. Taken together, our data suggest that CE has a browning effect in subcutaneous adipocytes. Our study suggests a natural non-toxic herbal remedy to reduce obesity.

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Section: Discussionmentioning

confidence: 99%

Cinnamon induces browning in subcutaneous adipocytes

Kwan

et al. 2017

Sci Rep

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“…(shown in sup.1). Our group has already conducted research on the functions and working mechanisms of the components, such as berberine, curcumin, ginsenoside and Corni Fructus [26–29]. In addition, the results from other researchers have also demonstrated anti-diabetic effect of some active ingredients of JTXK granule [30].…”

Section: Discussionmentioning

confidence: 99%

Anti-Diabetic Effects of Jiang Tang Xiao Ke Granule via PI3K/Akt Signalling Pathway in Type 2 Diabetes KKAy Mice

Fang

Zhao

et al. 2017

PLoS ONE

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Jiang Tang Xiao Ke (JTXK) granule, a Chinese herbal formula, has been used clinically to treat type 2 diabetes (T2DM) for decades. Our previous studies showed that JTXK granule exhibited anti-diabetic and anti-oxidative functions in experimental diabetic rats induced by a high fat diet and streptozotocin. However, the underlying mechanisms remain poorly understood. Herein, we aimed to investigate the therapeutic effect of JTXK granule on T2DM KKAy mice and the possible associations with skeletal muscle in the current study. Our results showed that JTXK granule significantly reduced food intake and body weight in T2DM KKAy mice. JTXK granule treatment also decreased the blood glucose and HbA1c levels and increased the insulin sensitivity in a time-dependent manner. Additionally, it ameliorated hyperlipidaemia and induced a lower free fatty acid level, displaying an effect on disorders of lipid metabolism. JTXK granule significantly increased the expression of insulin receptor substrate-1 (IRS-1), phosphoinositide 3-kinase (PI3K), protein kinase B (PKB/Akt) and glucose transporter 4 (Glut4) and decreased the expression of glycogen synthase kinase 3β (GSK3β). We concluded that JTXK granule is an effective drug for T2DM through regulating the PI3K/Akt signalling pathway in skeletal muscle.

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“…These data were also confirmed in subjects carrying a mutation in USF1 [82]. Also, steroid glycosides as ginsenoside Rb1 improved glucose and lipid metabolisms and reduced body weight in obese animals by up-regulating PRDM-16, PGC1α, and UCP-1 expression and WAT browning [83]. Transgenic overexpression of PRDM-16 in subcutaneous WAT protected mice from diet-induced obesity and insulin resistance [84].…”

Section: Anti-obesity Strategies and Reduction Of Cardiovascular Riskmentioning

confidence: 89%

Regulation of visceral and epicardial adipose tissue for preventing cardiovascular injuries associated to obesity and diabetes

González

Moreno-Villegas

González-Bris

et al. 2017

Cardiovasc Diabetol

166

131

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Nowadays, obesity is seriously increasing in most of the populations all over the world, and is associated with the development and progression of high-mortality diseases such as type-2 diabetes mellitus (T2DM) and its subsequent cardiovascular pathologies. Recent data suggest that both body fat distribution and adipocyte phenotype, can be more determinant for fatal outcomes in obese patients than increased general adiposity. In particular, visceral adiposity is significantly linked to long term alterations on different cardiac structures, and in developed forms of myocardial diseases such as hypertensive and ischaemic heart diseases, and diabetic cardiomyopathy. Interestingly, this depot may be also related to epicardial fat accumulation through secretion of lipids, adipokines, and pro-inflammatory and oxidative factors from adipocytes. Thus, visceral adiposity and its white single-lipid-like adipocytes, are risk factors for different forms of heart disease and heart failure, mainly in higher degree obese subjects. However, under specific stimuli, some of these adipocytes can transdifferentiate to brown multi-mitochondrial-like adipocytes with anti-inflammatory and anti-apoptotic proprieties. Accordingly, in order to improve potential cardiovascular abnormalities in obese and T2DM patients, several therapeutic strategies have been addressed to modulate the visceral and epicardial fat volume and phenotypes. In addition to lifestyle modifications, specific genetic manipulations in adipose tissue and administration of PPARγ agonists or statins, have improved fat volume and phenotype, and cardiovascular failures. Furthermore, incretin stimulation reduced visceral and epicardial fat thickness whereas increased formation of brown adipocytes, alleviating insulin resistance and associated cardiovascular pathologies.

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Ginsenoside Rb1 promotes browning through regulation of PPARγ in 3T3-L1 adipocytes

Cited by 96 publications

References 32 publications

Cinnamon induces browning in subcutaneous adipocytes

Cinnamon induces browning in subcutaneous adipocytes

Anti-Diabetic Effects of Jiang Tang Xiao Ke Granule via PI3K/Akt Signalling Pathway in Type 2 Diabetes KKAy Mice

Regulation of visceral and epicardial adipose tissue for preventing cardiovascular injuries associated to obesity and diabetes

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