Ginsenoside Rd attenuates neuroinflammation of dopaminergic cells in culture

Lin, Weifeng; Zhang, Y.-M.; Moldzio, Rudolf; Rausch, Wolf‐Dieter

doi:10.1007/978-3-211-73574-9_13

Cited by 57 publications

(26 citation statements)

References 30 publications

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“…Unlike eNOS, expression of iNOS is usually found to be increased in cancer, inflammatory diseases, organ injuries or by toxins such as lipopolysaccharide (Lin et al, 2007;Oh et al, 2004). Depression of iNOS expression has been suggested as one of the important mechanisms underlying cardioprotective effects of the active ingredients from ginseng (Chen et al, 2002;Park et al, 2009).…”

Section: Discussionmentioning

confidence: 98%

Ginseng protects rodent hearts from acute myocardial ischemia–reperfusion injury through GR/ER-activated RISK pathway in an endothelial NOS-dependent mechanism

Zhou

Hou

Luo

et al. 2011

Journal of Ethnopharmacology

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Section: Discussionmentioning

confidence: 98%

Ginseng protects rodent hearts from acute myocardial ischemia–reperfusion injury through GR/ER-activated RISK pathway in an endothelial NOS-dependent mechanism

Zhou

Hou

Luo

et al. 2011

Journal of Ethnopharmacology

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“…It also activates JNK and NF-jB (Zhang et al 2008;Hotamisligil et al 1993;Feinstein et al 1993). MAPKs such as ERK1/2, JNK, p38 MAP kinase, PI3 K/PKB, and SAPK regulate inflammatory reactions, proliferation, differentiation, apoptosis, and survival of cells (Lin et al 2007). PDs that have higher levels of Rb1 and Rd are a TNF-a antagonist, and they lower the synthesis of TNF-a through the inhibition of COX-2, phospho-ERK, and c-Jun expression (Widmann et al 1999).…”

Section: Discussionmentioning

confidence: 99%

Preventive effects of protopanaxadiol and protopanaxatriol ginsenosides on liver inflammation and apoptosis in hyperlipidemic apoE KO mice

et al. 2011

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Ginsenosides, bioactive compounds of Panax Ginseng C.A. Meyer, are divided into protopanaxadiol (PD) and protopanaxtriol (PT). The aim of this study was to evaluate the protective effects of different PD and PT combination ratios on liver inflammation and apoptosis in hyperlipidemic apo E KO mice. R1 (PD/PT = 1, high Rg 1 and Rb 1 ) and R2 (PD/PT = 2, high Re and Rd) extracts were intraperitoneally injected by 100 mg/kg/day at the 8th week. R1 and R2 improved atherogenic indices by increasing HDL and lowering total cholesterol (TC) and triacylglyceride (TG) selectively. R1 decreased lipid peroxides (LPO) level in plasma and liver tissue of hyperlipidemic mice, and R2 lowered plasma malondialdehyde(MDA) level. R1 and R2 not only regulated the expression of cyclooxygenase (COX)-2, IjB-a, phopho-ERK 1/2, and phopho-SAPK/JNK levels but also were significantly effective in blocking apoptotic signals, such as caspase-8, -9, as well as the cleavage of PARP in liver. Different combinational treatment of PD and PT extracts might ameliorate the liver inflammation and apoptosis in hyperlipidemic apo E KO mice, which is atherosclerotic animal model.

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“…Our results demonstrated that oral treatment of the herbal formula B401 effectively enhances both synthesis of An ingredient of the herbal formula B401 shown in Figure 1, the extract from P. ginseng, has been proven to reduce oxidative stress and inflammation. [22][23][24][25] Furthermore, Rg1 from P. ginseng can induce rapid nitric oxide production from eNOS through the phosphatidylinositol 3-kinase (PI3K)/protein kinase B (Akt) pathway. 26 The extract from A. membranaceus has been reported to reduce oxidative stress and enhance nitric oxide production.…”

Section: Discussionmentioning

confidence: 99%

Oral treatment with herbal formula B401 alleviates penile toxicity in aging mice with manganism

Wu¹,

Hsu²,

Lin³

et al. 2015

OTT

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Abstract:The present study aims to elucidate the roles of nitric oxide synthase activity, oxidative stress, inflammation, and apoptosis in penile toxicity of aging mice associated with excess manganese (Mn) treatment and to investigate the effect of oral treatment with the herbal formula B401 in this respect. ICR strain mice were divided into two groups: the vehicle (sham group) and the B401 (50 mg/kg) group. The mice were orally treated for 5 days; then a high single dose of MnCl 2 (100 mg/kg) was given by intraperitoneal injection to the mice. One day after MnCl 2 treatment, corpora cavernosal tissues of both Mn-treated mice and their controls were simultaneously sampled to examine their immunohistochemical staining and Western blot analysis. Nitric oxide (NO) production, levels of neuronal nitric oxide synthase (nNOS) and endothelial nitric oxide synthase (eNOS), expression levels of factors governing angiogenesis (vascular endothelial growth factor), oxidative stress (catalase, superoxide dismutase 2,4-hydroxynonenal), inflammation (tumor necrosis factor alpha), apoptosis (B-cell lymphoma 2 [Bcl-2], Bcl-2-associated X protein [Bax], cleaved poly(adenosine diphosphateribose) polymerase [c-PARP], cytochrome C, caspase-12, and caspase-3) were evaluated in penile corpus cavernosum of the mice. We found that penile toxicity in the mice was enhanced under excess Mn treatment through reduction of NOS activity and increase in oxidative stress, inflammation, and apoptosis in the penile cavernous tissue. Furthermore, the penile toxicity in mice with manganism was alleviated by oral B401 treatment through enhancement of both nitric oxide synthesis and angiogenesis, with simultaneous reduction of oxidative stress, inflammation, and apoptosis in penile corpus cavernosum. We suggest that the herbal formula B401 may serve as a potential dietotherapeutic supplement for penile toxicity or dysfunction in aging males.

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Ginsenoside Rd attenuates neuroinflammation of dopaminergic cells in culture

Cited by 57 publications

References 30 publications

Ginseng protects rodent hearts from acute myocardial ischemia–reperfusion injury through GR/ER-activated RISK pathway in an endothelial NOS-dependent mechanism

Ginseng protects rodent hearts from acute myocardial ischemia–reperfusion injury through GR/ER-activated RISK pathway in an endothelial NOS-dependent mechanism

Preventive effects of protopanaxadiol and protopanaxatriol ginsenosides on liver inflammation and apoptosis in hyperlipidemic apoE KO mice

Oral treatment with herbal formula B401 alleviates penile toxicity in aging mice with manganism

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