Ginsenoside Rg1 Inhibits Lipid Accumulation and ROS Production in 3T3‐L1 cells during Early Adipogenesis.

Abstract

Adipogenesis is the process of adipocyte differentiation which increases lipid accumulation and ROS production. Many studies revealed that obesity is caused by excessive lipid accumulation and it leads metabolic diseases. Also, ROS production by oxidative stress induced insulin resistance which accompanies obesity and is a risk factor of type 2 diabetes. Ginsenoside Rg1 is one of the major components in panaxa ginseng, as a class of steroid glycosides, and triterpene saponins. Our result showed that Rg1 decreased lipid accumulation, C/EBPα, PPARγ, aP2 mRNA expression, C/EBPα, PPARγ protein expression and ROS production in a dose‐dependent manner. In addition, protein expression of early aipogenic factor C/EBPβ which induces C/EBPα, PPARγ was reduced during early adipogenesis. Our data suggests that Ginsenoside Rg1 inhibits lipid accumulation and ROS generation during early adipocyte differentiation. Depend on these data, we are planning to investigate anti‐oxidative factors.