Ginsenoside Rg1 promotes astrocyte‐to‐neuron transdifferentiation in rat and its possible mechanism

Abstract

Spinal cord injury (SCI) is a severe incidence that contributes to deformity or even mortality, causing a big burden both on families and society. 1 A series of microenvironment changes in the epicenter of lesion after SCI inhibit the repair of neurons and finally hinder the motor functional recovery. 2 Following directly instantaneous impact after SCI, the secondary injury caused by inflammation and gliar scar

Ginsenoside Rg1 ameliorates depressive-like behavior by inhibiting NLRP3 inflammasome activation in mice exposed to chronic stress

“…Traditional Chinese medicines offer promising alternatives for treatment of heterogeneous mood disorders [19]. In traditional Chinese medicine, ginseng has long been used to treat mood disorders [19][20][21], and its major active ingredients, ginsenosides, appear to be effective against depression [20,22,23]. In particular, the ginsenoside Rg1 (GRg1), a protopanaxatriol-type saponin, exerts its effects by in uencing multiple processes in the brain, with few side effects [24].…”