Ginsenoside Rg1 Suppresses Pyroptosis via the NF-κB/NLRP3/GSDMD Pathway to Alleviate Chronic Atrophic Gastritis <i>In Vitro</i> and <i>In Vivo</i>

Zhou, Zehua; Hu, Cheng; Cui, Bo; You, Lisha; An, Rui; Liang, Kun; Wang, Xinhong

doi:10.1021/acs.jafc.4c01271

J. Agric. Food Chem.

2024

DOI: 10.1021/acs.jafc.4c01271

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Ginsenoside Rg1 Suppresses Pyroptosis via the NF-κB/NLRP3/GSDMD Pathway to Alleviate Chronic Atrophic Gastritis In Vitro and In Vivo

Zehua Zhou,

Cheng Hu,

Bo Cui

et al.

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Current study of pathogenetic mechanisms and therapeutics of chronic atrophic gastritis: a comprehensive review

Kuang,

Xu,

et al. 2024

Front. Cell Dev. Biol.

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Chronic atrophic gastritis (CAG) is a prevalent digestive system disease characterized by atrophy of the gastric mucosa and the disappearance of inherent gastric glands. According to the theory of Correa’s cascade, CAG is an important pathological stage in the transformation from normal condition to gastric carcinoma. In recent years, the global incidence of CAG has been increasing due to pathogenic factors, including Helicobacter pylori infection, bile reflux, and the consumption of processed meats. In this review, we comprehensively described the etiology and clinical diagnosis of CAG. We focused on elucidating the regulatory mechanisms and promising therapeutic targets in CAG, with the expectation of providing insights and theoretical support for future research on CAG.

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Current study of pathogenetic mechanisms and therapeutics of chronic atrophic gastritis: a comprehensive review

Kuang,

Xu,

et al. 2024

Front. Cell Dev. Biol.

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show abstract

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Ginsenoside Rg1 Suppresses Pyroptosis via the NF-κB/NLRP3/GSDMD Pathway to Alleviate Chronic Atrophic Gastritis In Vitro and In Vivo

Cited by 1 publication

References 45 publications

Current study of pathogenetic mechanisms and therapeutics of chronic atrophic gastritis: a comprehensive review

Current study of pathogenetic mechanisms and therapeutics of chronic atrophic gastritis: a comprehensive review

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