Ginsenoside Rg3 reduces the adhesion, invasion, and intracellular survival of Salmonella enterica serovar Typhimurium

Bioactive triple peptide inhibits inflammasome activation to alleviate Salmonella-induced intestinal inflammation in mice via modulation of host defense and bacterial virulence

“…For instance, ginsenoside Rg3 showed a repressive effect on the adhesion and invasion of S. typhimurium to Caco-2 and RAW 264.7 cells. 29 In our study, BTP also suppressed the adhesion and invasion of S. typhimurium to THP-1 cells, which might be a consequence of inhibited motility.…”

“…PMA-stimulated THP-1 cells were treated with different concentrations of BTP for 4 h and then infected with S. typhimurium (MOI = 20). Adhesion and invasion assays were performed according to the method described by Mechesso et al 29 For the adhesion assay, S. typhimurium-infected THP-1 cells were incubated at 37 °C for 45 min. Subsequently, the cells were washed twice with PBS and lysed with 1% Triton X-100.…”

“…This study found that BTP repressed the motility of S. typhimurium, which is a requisite to invade the host. 29 Many reports have suggested that inhibiting the adhesion and invasion of S. typhimurium may be a useful way to resist S. typhimurium infection. For instance, ginsenoside Rg3 showed a repressive effect on the adhesion and invasion of S. typhimurium to Caco-2 and RAW 264.7 cells.…”

Tylosin exposure reduces the susceptibility of Salmonella Typhimurium to florfenicol and tetracycline

“…Typhimurium LVPP-STI2 [33]. In addition, our recent studies confirmed the invasive, quorum sensing and virulence potentials of these strains [34,35].…”

The protective effect and potential mechanisms of eugenol against Salmonella in vivo and in vitro

“…Our previous study has proved eugenol exposure in vitro inhibits the expressions of T3SS and Type I fimbriae ( TIF ) virulence genes in S. Typhimurium, then resulting in a significantly reduction of pathogenicity to chickens ( Zhao et al., 2022 ). It has been reported that ginsenoside Rg3 significantly reduced in S. Typhimurium strains adhesion to RAW 246.7 cells ( Mechesso et al., 2021 ). In this study, our results showed that eugenol decreased the adhesion and invasion of S. Typhimurium to IEC-6 and RAW264.7 cells.…”