Ginsenoside Rg5 overcomes chemotherapeutic multidrug resistance mediated by ABCB1 transporter: in vitro and in vivo study

Feng, Senling; Luo, Hai‐Bin; Cai, Liang; Zhang, Jie; Wang, Dan; Chen, Ying-Jiang; Zhan, Huan-Xing; Jiang, Zhihong; Xie, Yu

doi:10.1016/j.jgr.2018.10.007

Cited by 28 publications

(17 citation statements)

References 44 publications

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“…Ginsenoside Rg5 is a sterol present in ginseng with antioxidant activity [ 117 ]. Rg5 inhibits fatty acid oxidation, improves pyruvate dehydrogenase activity, and prevents cell acidification.…”

Section: Ischaemia/reperfusionmentioning

confidence: 99%

[Retracted] Natural Antioxidants Improve the Vulnerability of Cardiomyocytes and Vascular Endothelial Cells under Stress Conditions: A Focus on Mitochondrial Quality Control

Chang

Zhao

Zhang

et al. 2021

Oxidative Medicine and Cellular Longevity

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Cardiovascular disease has become one of the main causes of human death. In addition, many cardiovascular diseases are accompanied by a series of irreversible damages that lead to organ and vascular complications. In recent years, the potential therapeutic strategy of natural antioxidants in the treatment of cardiovascular diseases through mitochondrial quality control has received extensive attention. Mitochondria are the main site of energy metabolism in eukaryotic cells, including myocardial and vascular endothelial cells. Mitochondrial quality control processes ensure normal activities of mitochondria and cells by maintaining stable mitochondrial quantity and quality, thus protecting myocardial and endothelial cells against stress. Various stresses can affect mitochondrial morphology and function. Natural antioxidants extracted from plants and natural medicines are becoming increasingly common in the clinical treatment of diseases, especially in the treatment of cardiovascular diseases. Natural antioxidants can effectively protect myocardial and endothelial cells from stress-induced injury by regulating mitochondrial quality control, and their safety and effectiveness have been preliminarily verified. This review summarises the damage mechanisms of various stresses in cardiomyocytes and vascular endothelial cells and the mechanisms of natural antioxidants in improving the vulnerability of these cell types to stress by regulating mitochondrial quality control. This review is aimed at paving the way for novel treatments for cardiovascular diseases and the development of natural antioxidant drugs.

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Section: Ischaemia/reperfusionmentioning

confidence: 99%

[Retracted] Natural Antioxidants Improve the Vulnerability of Cardiomyocytes and Vascular Endothelial Cells under Stress Conditions: A Focus on Mitochondrial Quality Control

Chang

Zhao

Zhang

et al. 2021

Oxidative Medicine and Cellular Longevity

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“…Through an in vitro and in vivo study, Rg 5 controlled chemotherapeutic multidrug resistance (MDR) mediated by ABCB1 transporter via the increase of the accumulation of ABCB1 substrates intracellularly [93]. In addition, the combination of Rg 5 and docetaxel (TXT) in nude mice bearing an A549/T tumor could suppress the growth of drug-resistant tumors significantly through the suppression of AKT phosphorylation and Nrf2 expression [94].…”

Section: Pharmacological Studiesmentioning

confidence: 99%

Black Ginseng and Its Saponins: Preparation, Phytochemistry and Pharmacological Effects

et al. 2019

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Black ginseng is a type of processed ginseng that is prepared from white or red ginseng by steaming and drying several times. This process causes extensive changes in types and amounts of secondary metabolites. The chief secondary metabolites in ginseng are ginsenosides (dammarane-type triterpene saponins), which transform into less polar ginsenosides in black ginseng by steaming. In addition, apparent changes happen to other secondary metabolites such as the increase in the contents of phenolic compounds, reducing sugars and acidic polysaccharides in addition to the decrease in concentrations of free amino acids and total polysaccharides. Furthermore, the presence of some Maillard reaction products like maltol was also engaged. These obvious chemical changes were associated with a noticeable superiority for black ginseng over white and red ginseng in most of the comparative biological studies. This review article is an attempt to illustrate different methods of preparation of black ginseng, major chemical changes of saponins and other constituents after steaming as well as the reported biological activities of black ginseng, its major saponins and other metabolites.

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“…Rg5 also promotes human cervical cancer cell apoptosis in concentration- and time-dependent manners by inducing DNA double-strand breaks and fragments ( 11 ). Rg5 has also been demonstrated to effectively overcome ATP binding cassette subfamily B member 1 (ABCB1)-mediated drug resistance by inhibiting ABCB1 transporter and blocking the activation of Akt/nuclear-related factor 2 pathways without affecting the expression of ABCB1 transporter ( 31 ). Therefore, Rg5 may serve as a chemosensitizer for reversing multidrug resistance.…”

Section: Pharmacological Activities Of Rg5mentioning

confidence: 99%

Pharmacological activities of ginsenoside Rg5 (Review)

Liu

Gao

et al. 2021

Exp Ther Med

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Ginseng, a perennial plant belonging to genus Panax , has been widely used in traditional herbal medicine in East Asia and North America. Ginsenosides are the most important pharmacological component of ginseng. Variabilities in attached positions, inner and outer residues and types of sugar moieties may be associated with the specific pharmacological activities of each ginsenoside. Ginsenoside Rg5 (Rg5) is a minor ginsenoside synthesized during ginseng steaming treatment that exhibits superior pharmaceutical activity compared with major ginsenosides. With high safety and various biological functions, Rg5 may act as a potential therapeutic candidate for diverse diseases. To date, there have been no systematic studies on the activity of Rg5. Therefore, in this review, all available literature was reviewed and discussed to facilitate further research on Rg5.

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Ginsenoside Rg5 overcomes chemotherapeutic multidrug resistance mediated by ABCB1 transporter: in vitro and in vivo study

Cited by 28 publications

References 44 publications

[Retracted] Natural Antioxidants Improve the Vulnerability of Cardiomyocytes and Vascular Endothelial Cells under Stress Conditions: A Focus on Mitochondrial Quality Control

[Retracted] Natural Antioxidants Improve the Vulnerability of Cardiomyocytes and Vascular Endothelial Cells under Stress Conditions: A Focus on Mitochondrial Quality Control

Black Ginseng and Its Saponins: Preparation, Phytochemistry and Pharmacological Effects

Pharmacological activities of ginsenoside Rg5 (Review)

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