Ginsenoside Rk2, a dehydroprotopanaxadiol saponin, alleviates alcoholic liver disease via regulating NLRP3 and NLRP6 inflammasome signaling pathways in mice

Zou, Jian; Yang, Rujie; Feng, Ruibing; Liu, Jiayue; Wan, Jian‐Bo

doi:10.1016/j.jpha.2023.05.005

Cited by 10 publications

(2 citation statements)

References 59 publications

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“…The weights of the mice were recorded at a set time each day. The changes in food intake, water consumption, mental state observe and record the behavioral activities of each group of mice (Zou et al, 2023).…”

Section: General Observation Of Experimental Animalsmentioning

confidence: 99%

Structural characterization of Aspalatus linearis polysaccharide and its improving effect on acute alcoholic liver injury

Zhang,

Liu,

et al. 2024

Journal of Food Science

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Polysaccharides from natural sources can regulate the composition of intestinal flora through the “gut‐liver axis” pathway, potentially ameliorating alcoholic liver injury. Aspalathus linearis, also known as rooibos, is one such natural product that has shown promise in this regard. This study looked at the structural properties of A. linearis polysaccharide (ALP) and how well it would work to treat acute alcoholic liver impairment. This study looks at the composition of monosaccharides, functional groups, and molecular weight (Mw) of a newly discovered water‐soluble polysaccharide, named ALP. The polysaccharide is composed of pyranose rings, amide groups, and sulfate groups linked by β‐glycosidic linkage. It has a relative Mw of 4.30 × 103 kDa and is composed of glucose, rhamnose, and some other monosaccharides. The study found that treating mice with the model of acute alcoholic liver disease with ALP could alleviate pathological symptoms, inhibit the release of inflammatory cytokines, and suppress indicators of oxidative stress. Experiments have shown that different doses of ALP can activate the P4502E1/Keap1‐Nrf2‐HO‐1 signaling pathway. The regulation of inflammatory factors and downstream antioxidant enzymes occurs as a result. Based on these data, it is likely that ALP protects the liver via the “gut‐liver axis” pathway by reducing oxidative stress‐related damage, inflammation, and alcohol‐related alterations to the gut microbiome. The results indicate that ALP mitigates injury caused by oxidative stress, inflammatory responses, and changes in the gut microbiota induced by alcohol through the “gut‐liver axis” pathway, which provides protection to the liver. This provides preliminary evidence for the development of related drugs.Practical ApplicationResearchers extracted a polysaccharide from fresh leaves of Auricularia auricula. The polysaccharide was purified and determined to have a predominantly homogeneous molecular weight. An acute alcoholic liver damage mouse model was established, and it was concluded that the polysaccharide could ameliorate liver injury in mice through the “gut‐liver axis” pathway. This novel polysaccharide can be used as an additive to develop functional foods with beneficial effects, which can positively impact the daily maintenance of consumers.

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Section: General Observation Of Experimental Animalsmentioning

confidence: 99%

Structural characterization of Aspalatus linearis polysaccharide and its improving effect on acute alcoholic liver injury

Zhang,

Liu,

et al. 2024

Journal of Food Science

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“…Frequently, ALI initially manifests as fatty liver disease, which further develops into alcoholic steato-hepatitis, alcoholic hepatic fibrosis, and alcoholic cirrhosis. In particular, severe alcoholism may result in large-scale hepatocellular necrosis and even liver cancer [6,7]. Therefore, it is urgent to seek medicines or nutraceuticals to prevent and treat ALI and to elucidate their mechanisms of action.…”

Section: Introductionmentioning

confidence: 99%

Protective Effects and Mechanism of Polysaccharides from Edible Medicinal Plants in Alcoholic Liver Injury: A Review

Su,

Yan,

Feng

et al. 2023

IJMS

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Alcohol use accounts for a large variety of diseases, among which alcoholic liver injury (ALI) poses a serious threat to human health. In order to overcome the limitations of chemotherapeutic agents, some natural constituents, especially polysaccharides from edible medicinal plants (PEMPs), have been applied for the prevention and treatment of ALI. In this review, the protective effects of PEMPs on acute, subacute, subchronic, and chronic ALI are summarized. The pathogenesis of alcoholic liver injury is analyzed. The structure–activity relationship (SAR) and safety of PEMPs are discussed. In addition, the mechanism underlying the hepatoprotective activity of polysaccharides from edible medicinal plants is explored. PEMPs with hepatoprotective activities mainly belong to the families Orchidaceae, Solanaceae, and Liliaceae. The possible mechanisms of PEMPs include activating enzymes related to alcohol metabolism, attenuating damage from oxidative stress, regulating cytokines, inhibiting the apoptosis of hepatocytes, improving mitochondrial function, and regulating the gut microbiota. Strategies for further research into the practical application of PEMPs for ALI are proposed. Future studies on the mechanism of action of PEMPs will need to focus more on the utilization of multi-omics approaches, such as proteomics, epigenomics, and lipidomics.

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Protective effects of Panax ginseng as a medical food against chemical toxic agents: molecular and cellular mechanisms

Rameshrad,

Naraki,

Memariani

et al. 2024

Naunyn-Schmiedeberg's Arch Pharmacol

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Ginsenoside Rk2, a dehydroprotopanaxadiol saponin, alleviates alcoholic liver disease via regulating NLRP3 and NLRP6 inflammasome signaling pathways in mice

Cited by 10 publications

References 59 publications

Structural characterization of Aspalatus linearis polysaccharide and its improving effect on acute alcoholic liver injury

Structural characterization of Aspalatus linearis polysaccharide and its improving effect on acute alcoholic liver injury

Protective Effects and Mechanism of Polysaccharides from Edible Medicinal Plants in Alcoholic Liver Injury: A Review

Protective effects of Panax ginseng as a medical food against chemical toxic agents: molecular and cellular mechanisms

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