Ginsenosides Action on Spontaneous Sleep in Rats

Abstract

Abstract-This work was performed to study the influences of Ginsenosides (GS) on spontaneous sleep. Adult SD rats were randomly divided into the control, GS 10 and 100mg/kg groups. After recovery from operation, rats were orally administered GS 10 and 100mg/kg or water once per day for 6 days. On day 1 and 6, Polygraphic signs of undisturbed sleep-wake activities were recorded for 12h after GS administration. On day 1, only 100mg/kg GS increased significantly NREM and total sleep but decreased wakefulness; 10 and 100mg/kg GS enhanced θ power of NREM and wakefulness but reduced θ power of wakefulness and α power during sleep and wakefulness, 10 and 100mg/kg GS lowered θ power of NREM and REM stage, respectively. On day 6, both 10 and 100mg/kg GS increased markedly NREM and total sleep but lowered wakefulness and sleep-wake cycles; 10 and 100mg/kg GS enhanced δ power during NREM and wakefulness but reduced θ power of wakefulness and α power during sleep and wake state, 10mg/kg GS also lowered θ power of NREM. The increase of δ power in all stages, the decrease of θ power in NREM and REM sleep and the decrease of α power during NREM and wakefulness were observed in 10mg/kg group; the decrease of θ power during NREM sleep and of α power during wakefulness and the increase of δ power in wakefulness shown in 100mg/kg group. These findings indicate that GS can regulate spontaneous sleep in time-dependent manner, cortical EEG power spectra in rats.