GIPR rs1800437 polymorphism: prevalence and possible associations with metabolic syndrome-related diseases in a Brazilian urban population

Mattos, Alexandro Márcio da Silva; Ludwig, Natasha Guimarães; Koga, Gustavo Kendy Camargo; Costa, S.C.; Amarante, Marla Karine; Mazzuco, Tânia Longo

doi:10.1186/1758-5996-7-s1-a200

Cited by 4 publications

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“…The C mutant allele was found in 27% of the population, with a higher prevalence in Caucasians. No significant association was found between the SNP and BMI, obesity and diabetes . An exchange of the allele G to C in the rs1800437 variant influences an exchange of glutamate to glutamine in transmembrane domain six.…”

Section: Discussionmentioning

confidence: 89%

“…In the present study, we found a significant association between SNP rs1800437 and BMI. Other studies showed no significant association between the SNP rs1800437 variant and an increased BMI in Brazilian, German and Danish populations . Furthermore, Vogel et al .…”

Section: Discussionmentioning

confidence: 91%

“…Although the physiological studies visibly determined the important role of the GLP‐1R and GIPR in glucose homeostasis, the role of genetic polymorphisms within these genes for normal and abnormal glucose metabolism still remains inconsistent. Few studies have investigated the association of GIPR and GLP‐1R variations with T2DM in different populations and the results are controversial. No previous studies have assessed the relationship between GIPR and GLP‐1R gene polymorphisms and T2DM in Egyptians.…”

Section: Introductionmentioning

confidence: 99%

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Association of incretin receptors genetic polymorphisms with type 2 diabetes mellitus in Egyptian patients

Shalaby

Zidan

Shokry

et al. 2017

The Journal of Gene Medicine

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We reveal for the first time an association between the GIPR rs2302382 polymorphism and T2DM in Egyptians. Yet, there was no significant association of GIPR rs1800437 or GLP-1R rs367543060 with T2DM risk. The haplotype A (rs2302382) C (rs1800437) was associated with an increased risk of T2DM. Furthermore, there was a significant increase of GIP and a significant decrease of GLP-1 levels when diabetic patients were compared with controls. An important finding was that there was a relationship between both GIPR rs2302382 and rs1800437 variants and their cognate ligand levels.

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Section: Discussionmentioning

confidence: 89%

Section: Discussionmentioning

confidence: 91%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Association of incretin receptors genetic polymorphisms with type 2 diabetes mellitus in Egyptian patients

Shalaby

Zidan

Shokry

et al. 2017

The Journal of Gene Medicine

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“…Our preliminary results involving cardiometabolic risk factors has pointed to the potential role for the GIPR Glu354Gln genetic variant in systemic arterial hypertension (13). The aim of the present study was to assess the prevalence of the GIPR Glu354Gln in a Brazilian population and to investigate its association with socio-demographic and clinical characteristics related to the cardiometabolic syndrome.…”

Section: Introductionmentioning

confidence: 79%

Association of theGIPRGlu354Gln (rs1800437) polymorphism with hypertension in a brazilian population

Mattos

Outuki

et al. 2018

Preprint

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25 26 Objective: To know the prevalence of the Glu354Gln polymorphism of 27 the GIPR gene, investigate possible associations with arterial hypertension and 28 relationships with cardiometabolic diseases. Method: A total of 311 subjects 29 recruited from the Clinical Hospital of Londrina State University, located in a 30 Brazilian metropolitan area. Random stratification was performed considering 31 gender and geographic regions. Data were collected through interviews 32 including anthropometric, sociodemographic and metabolic diseases related 33diseases. In order to analyze GIPR Glu354Gln gene polymorphism, 34 polymerase chain reaction followed by followed by restriction fragment length 35 polymorphism (PCR-RFLP) was performed. Results: The highest prevalence 36 for the allele C carriers were found in the Caucasian 29.4% (p = 0.043, OR = 37 1,89), hypertensive 37.1% (p < 0.0001), smokers 38.3% (p = 0.014) and 38 dyslipidemic group 41.2% (p = 0.019). In this work 46.9% of the participants (n 39 = 146) presented diseases related to cardiometabolic diseases. The results 40 indicated that 60% of hypertensive patients (p = 0.004) and 64.7% of 41 dyslipidemic patients (p = 0.046) were male. Among participants who presented 42 cardiometabolic diseases, arterial hypertension was the most prevalent disease 43 (71.9%), followed by obesity (43.8%). The family comorbidities history to 44 cardiometabolic diseases (DM2, AH, dyslipidemia and obesity) had no 45 significant association with the GIPR Glu354Gln genetic polymorphism. 46Although there was no difference in the case-control analyses for GIPR 47 3 48 twice associated with arterial hypertension (p<0,001) and dyslipidemia 49 (p<0,03). Conclusion: The prevalence of the GIPR Glu354Gln for the CC 50 genotype and for the C polymorphic allele was 25.7% and 3.2%, respectively. 51This study shows the potential participation of the GIPR Glu354Gln 52 polymorphism with the pathophysiology of arterial hypertension, dyslipidemia 53 in this Brazilian population. Taking into account the rarity of the CC genotype, 54 additional studies with larger numbers of participants could contribute to a 55 better understanding. 56 57 65 adipocytes, pancreas, lung, adrenal, kidney and thyroid (1). Nonpancreatic 66 GIPR function is related to adrenal cell proliferation, GIP-dependent 67 oversecretion of cortisol and aldosterone (4, 5, 6) and neurogenesis in the 68 central nervous system (6). 69 Several GIP receptor polymorphisms have been described. These 70 genetic variations could play a role on gluco-insulin homeostasis and body 4 4 71 composition. Some single nucleotide polymorphisms (SNPs) located in coding 72 regions of the GIPR gene (rs8111428, rs2302382 and rs1800437) were related 73 to obesity (7). The GIPR rs10423928 was associated with high postprandial 74 glucose and insulin levels (8), decreased lean mass (9) and low BMD in early 75 postmenopausal women (10). The GIPR SNP rs1800437 (Glu354Gln) showed 76 a borderline association with cardiovascular disease (CVD) in a study of 200 77 p...

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The Role of Single Nucleotide Polymorphisms in the GIPR Gene in Regulation of Secretion of Hormones and Adipokines in Obese Patients with Type 2 Diabetes Mellitus

Skuratovskaia

Vulf

Kirienkova

et al. 2018

Biochem. Moscow Suppl. Ser. B

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GIPR rs1800437 polymorphism: prevalence and possible associations with metabolic syndrome-related diseases in a Brazilian urban population

Cited by 4 publications

References 0 publications

Association of incretin receptors genetic polymorphisms with type 2 diabetes mellitus in Egyptian patients

Association of incretin receptors genetic polymorphisms with type 2 diabetes mellitus in Egyptian patients

Association of theGIPRGlu354Gln (rs1800437) polymorphism with hypertension in a brazilian population

The Role of Single Nucleotide Polymorphisms in the GIPR Gene in Regulation of Secretion of Hormones and Adipokines in Obese Patients with Type 2 Diabetes Mellitus

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