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Galenko-Yaroshevskii, A. P.; Derlugov, L. P.; Ponomarev, V. V.; Dukhanin, A. S.

doi:10.1023/a:1026323124831

Cited by 9 publications

(3 citation statements)

References 2 publications

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“…45 On the other hand, the local anesthetic bupivacaine was reported to possess an inhibitory action over PChE activity. 46 This effect could explain the reduction in PChE activity in the SA group of the present study.…”

Section: Discussionmentioning

confidence: 54%

Changes in blood oxidative stress biomarker and cholinesterase activity after general vs spinal anesthesia for elective cesarean sections

Karam,

Mohammad

2023

Anaesth. pain intensive care

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Background & Objective: There is an increased ratio of cesarean sections (CS) compared to normal deliveries the world over. Both general and regional anesthetic techniques are in practice for CS. Limited information is available on the determination of blood cholinesterase (ChE) activity in conjunction with oxidative stress biomarkers after the CS. The purpose of the present study was to determine and compare the plasma and erythrocyte ChE activity as well as malondialdehyde (MDA) level and total antioxidant status in pregnant women before anesthesia and after the use of general anesthesia (GA) or spinal anesthesia (SA) for elective CS. Methodology: A pre-post study was conducted on 102 full-term pregnant women, who underwent elective CS in four hospitals at Duhok (Iraq) from January 2022 to July 2022. GA with propofol and SA with bupivacaine 0.5% were administered to 52 and 50 women, respectively. Maternal blood samples before anesthesia and after the completion of operation were assayed for the ChE activity in the plasma and erythrocytes, and plasma oxidative stress biomarkers malondialdehyde and total antioxidant status. Results: Plasma ChE activity significantly decreased in the GA and SA groups after the cesarean-deliveries compared to the corresponding pre-anesthetic values. The plasma MDA level in both GA and SA groups, but not the total antioxidant status, was significantly reduced. Estimation of the odds ratio and the relative risk indicated that a risk factor is associated with the reduced plasma ChE activity in women after the CS when the general anesthetic propofol is used. Conclusion: Both general anesthesia with propofol and spinal anesthesia with bupivacaine inhibited plasma cholinesterase activity and reduced oxidative stress biomarker malondialdehyde after the cesarean sections. Abbreviations: CS - Cesarean section; ChE: Cholinesterase; EChE: Erythrocyte Cholinesterase; MDA: Malondialdehyde; OS: Oxidative Stress; PChE: Plasma ChE; TAS: Total Antioxidant Status. Key words: Anesthesia, Spinal; Cesarean section; General anesthesia; Malondialdehyde; Oxidative stress Citation: Karam RS, Mohammad FK. Changes in blood oxidative stress biomarker and cholinesterase activity after general vs spinal anesthesia for elective cesarean sections. Anaesth. pain intensive care 2023;27(3):396−404; DOI: 10.35975/apic.v27i3.2244 Received: March 23, 2023; Reviewed: May 06, 2023; Accepted: May 09, 2023

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Section: Discussionmentioning

confidence: 54%

Changes in blood oxidative stress biomarker and cholinesterase activity after general vs spinal anesthesia for elective cesarean sections

Karam,

Mohammad

2023

Anaesth. pain intensive care

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“…However, the use of fluorescent probes for evaluation of kinetic parameters of HAS-LA interaction is impossible [6,8]. To this end, the radioligand methods are most frequently used, which quantitatively assess binding of a 3 H-, 14 C-, or 125 I-labeled compound.…”

Section: Resultsmentioning

confidence: 99%

Kinetics of Interaction of Local Anesthetics with Human Serum Albumin

2005

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We studied kinetic parameters of interaction of local anesthetics (lidocaine, tetracaine, bupivacaine, and two novel agents with proved local anesthetic potency RU-353 and RU-1117) with human serum albumin. Complexation of local anesthetics with human serum albumin is a time-dependent and reversible process; equilibrium was attained within 1.5-4.5 h depending on chemical nature of local anesthetics.

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“…human serum albumin (HSA); the results can be used for prediction of the pharmacokinetic and pharmacodynamic characteristics of LA: the degree and duration of the anesthetic effect, rate of metabolism and/ or utilization in peripheral tissues [1,2].…”

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confidence: 99%

Conformation and kinetic characteristics of interactions between local anesthetics and aqueous solutions of hydroxypropylmethylcellulose

Galenko-Yaroshevskii¹,

Варлашкина²,

Тахчиди

et al. 2007

Bull Exp Biol Med

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Conformation and kinetic characteristics of the interactions of local anesthetics lidocaine (xycaine), tetracaine (dicaine), bupivacaine, and new RU-1117 compound with proven anesthetic activity with Visiton (1% hydroxypropylmethylcellulose in phosphate buffer) were studied. It was found that complex formation between the local anesthetics and hydroxypropylmethylcellulose is a time-dependent reversible process. The equilibrium is attained within 2.5-8.0 h and depends on the chemical nature of local anesthetic.

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Cited by 9 publications

References 2 publications

Changes in blood oxidative stress biomarker and cholinesterase activity after general vs spinal anesthesia for elective cesarean sections

Changes in blood oxidative stress biomarker and cholinesterase activity after general vs spinal anesthesia for elective cesarean sections

Kinetics of Interaction of Local Anesthetics with Human Serum Albumin

Conformation and kinetic characteristics of interactions between local anesthetics and aqueous solutions of hydroxypropylmethylcellulose

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