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Abstract

The use of crude cartilage for the treatment of human cancers remains a subject of controversy. In this brief commentary, we reviewed the current knowledge on the anticancer properties of cartilage. We then presented the properties of AE-941, a novel standardized water-soluble extract derived from shark cartilage that represents less than 5% of the crude cartilage. It is a multifunctional antiangiogenic product that contains several biologically active molecules. EA-941 is one of the few antiangiogenic drugs that is under phase III clinical investigation. It is currently evaluated in Europe and North America for the treatment of refractory renal cell carcinoma and in North America for metastatic non small cell lung cancer.

Comparative Study for the Therapeutic Effect of Shark Care and 5-Fluorouracil Drugs in Mice with Hepatocelluar Carcinoma in the Presence of Electric Field

“…In the present work Histological examination was performed on all study groups and Coded H and E stained slides were examined microscopically by a single pathologist using a high power (magnification, ×400), and at least five high-power fields were examined to detect histopathological changes: gp (A) (control); showed 1-normal hepatic architectiure, gp (B-1), (That donot recive any treatment); showed less preserved hepatic architecture with focal cytoplasmic vaculation of hepatocyte, mild fibrosis and lymphatic infiltration 2-vascular degeneration and ballooning of hepatocyte with moderate fibrosis 3-areas of coagulative necrosis 4-various degree of dysplasia and finally HCC, gp (B-2) (which treated by injected by 120 mg/kg of 5-Fluorouracil); showed moderate lymphatic infiltration also moderate necrosis and moderate nuclear displeases (nuclear elnargment prominent nuclei), gp (B-3) (which treated by shark care drug dissolved in drinking water daily); showed showed miled lymphatic infiltration also mild necrosis and mild nuclear displeases (nuclear elnargment prominent nuclei), gp (B-2-ii) and gp (B-3-ii) were exposed to electric field for 5 second and the last part gp (B-2-iii) and gp (B-3iii) were exposed to electric field for 10 second; showed no fibrosis and no necrosis with relative chromatin distribution and relativelynormal hepatocyte. Figures (7)(8)(9)(10)(11)(12)(13)(14)(15)(16) show set of the measured permittivity, and conductivity with the frequency of mice liver tissues of gp (A) (control), gp (B-2) (which treated by injected by 120 mg/kg of 5-Fluorouracil) and gp (B-3) (which treated by shark care drug dissolved in drinking water daily). Generally, the permiitivity decrease, while the real conductivity increases with increasing of frequeny.…”

“…Generally, the permiitivity decrease, while the real conductivity increases with increasing of frequeny. Figure (12): Variation of conductivity with frequency of mice liver tissues treated by injected by 120 mg/kg of 5-Fluorouracil after exposed to electric field for 10 sec.…”

“…(11) Shark care drug is a purified Shark cartilage extract composed of the following ingredients: proteins: (Collagen, U-995 protein and SCF2 protein), glycosaminoglycans: (Chondroitin-6sulfate and keratin sulphate) and calcium salts. (12) Many drugs that have the potential to treat cancers have had limited success due to their lack of efficient and safe delivery mechanisms that allow the drug molecules to cross cell membranes. Electrical pulses-mediated drug delivery, known as electroporation, is gaining attention as a possible approach to enhance uptake of chemotherapy.…”

Stereocontrolled Total Syntheses of Shark Cartilage Chondroitin Sulfate D-Related Tetra- and Hexasaccharide Methyl Glycosides

“…However, clinical trials supporting their beneficial effects are still the subject of severe controversy. [10] More relevant was the finding that CS-D plays an important role in brain development, [11] and exhibits a neurite outgrowth-promoting activity toward embryonic rat mesencephalic and hippocampal neurons. [12] It is now well established that most of the observed biological functions of GAGs depend on binding with proteins.…”

Lung Cancer in a Male Smoker Treated by Adjunct Nutritional and Phyto-Therapy

“…The link between angiogenesis and tumour progression is strong [62]. Bioavailable shark cartilage can inhibit proliferation of blood capillaries induced by tumours [63,64].…”