Glabridin from <i>Glycyrrhiza glabra</i> Possesses a Therapeutic Role against Keloid via Attenuating PI3K/Akt and Transforming Growth Factor-β1/SMAD Signaling Pathways

Zhang, Qing; Qian, Die; Tang, Dandan; Liu, Jia; Wang, Lin-Yu; Chen, Wenwen; Wu, Chunjie; Peng, Wei

doi:10.1021/acs.jafc.2c02045

Cited by 18 publications

(16 citation statements)

References 33 publications

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“…The hydrophilic fraction of liquorice extracts is known to have anti-inflammatory effects [85]. Glabridin's effectiveness against keloid fibroblasts was shown by Zhang et al [86]'s experiment. Glabridin is a flavonoid obtained from the plant Glycyrrhiza glabra that possesses a variety of biological characteristics.…”

Section: Glycyrrhiza Glabra (Liquorice)mentioning

confidence: 97%

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Keloids: A Review of the Diseases, Causes, and Current Treatments

Anirudh¹,

Gomathi²,

Sujatha³

et al. 2022

JPRI

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Keloids are benign tumors that grow as a result of excessive collagen release from overexpressed fibroblasts. Keloids and hypertrophic scars are distinguished by the fact that keloids develop beyond the site of the original lesion, but hypertrophic scars do not. It is still unclear why this mechanism operates, mainly when aberrant scarring occurs. Despite several treatments' availability, the keloids' recurrence rate remains high. Here, we summarize recent narrative reviews, systematic reviews, and meta-analyses to give a general overview of the condition, its underlying causes, and available therapies for keloids. To undertake a comprehensive investigation of the disease, over 100 publications were reviewed utilizing Google Scholar and Pubmed. We also shed light on using phytochemicals as a natural alternative to prevent keloid scarring, which occurs when the body responds abnormally to external injuries by producing scar tissue. We also summarize the available current treatments.

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Section: Glycyrrhiza Glabra (Liquorice)mentioning

confidence: 97%

“…Glabridin was also found to inhibit the production of collagen. The cause was shown to be the suppression of the PI3K/Akt and TGFβ-1/SMAD pathways [86]. Liquorice could be a potential therapeutic agent for keloid treatment with further research.…”

Section: Glycyrrhiza Glabra (Liquorice)mentioning

confidence: 99%

Keloids: A Review of the Diseases, Causes, and Current Treatments

Anirudh¹,

Gomathi²,

Sujatha³

et al. 2022

JPRI

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“…Several non-canonical TGF-b pathways are involved in keloid formation. These include the MAPK (94,198,199), ERK 1/2 (44,200) phosphatidylinositol-3-kinase (P-I3K)/AKT (44,104,(200)(201)(202), c-Jun amino-terminal kinase (94), p38 mitogen-activated protein kinase (p38/MAPK) (94,(203)(204)(205), and Rho-like (82) signaling pathways. The multi-kinase inhibitor sorafenib induces cell arrest of keloid fibroblasts by blockade of the intracellular TGF-b/Smad and MAPK/ ERK pathways (206).…”

Section: Non-canonical Tgf-b Pathwaysmentioning

confidence: 99%

An updated review of the immunological mechanisms of keloid scars

et al. 2023

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Keloid is a type of disfiguring pathological scarring unique to human skin. The disorder is characterized by excessive collagen deposition. Immune cell infiltration is a hallmark of both normal and pathological tissue repair. However, the immunopathological mechanisms of keloid remain unclear. Recent studies have uncovered the pivotal role of both innate and adaptive immunity in modulating the aberrant behavior of keloid fibroblasts. Several novel therapeutics attempting to restore regulation of the immune microenvironment have shown variable efficacy. We review the current understanding of keloid immunopathogenesis and highlight the potential roles of immune pathway-specific therapeutics.

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“…Therefore, alternative approaches are urgently needed, natural products have always held a privileged position as valuable sources and inspirations for new drug development ( Newman and Cragg, 2020 ). Some Chinese medicines show promising anti-fibrotic effects ( El-Tantawy and Temraz, 2022 ; Zhang et al, 2022a ).…”

Section: Introductionmentioning

confidence: 99%

Astragalus and its formulas as a therapeutic option for fibrotic diseases: Pharmacology and mechanisms

Zhu¹,

Chai

Xiao

et al. 2022

Front. Pharmacol.

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Fibrosis is the abnormal deposition of extracellular matrix, characterized by accumulation of collagen and other extracellular matrix components, which causes organ dysfunction and even death. Despite advances in understanding fibrosis pathology and clinical management, there is no treatment for fibrosis that can prevent or reverse it, existing treatment options may lead to diarrhea, nausea, bleeding, anorexia, and liver toxicity. Thus, effective drugs are needed for fibrotic diseases. Traditional Chinese medicine has played a vital role in fibrotic diseases, accumulating evidence has demonstrated that Astragalus (Astragalus mongholicus Bunge) can attenuate multiple fibrotic diseases, which include liver fibrosis, pulmonary fibrosis, peritoneal fibrosis, renal fibrosis, cardiac fibrosis, and so on, mechanisms may be related to inhibition of epithelial-mesenchymal transition (EMT), reactive oxygen species (ROS), transforming growth factor beta 1 (TGF-β1)/Smads, apoptosis, inflammation pathways. The purpose of this review was to summarize the pharmacology and mechanisms of Astragalus in treating fibrotic diseases, the data reviewed demonstrates that Astragalus is a promising anti-fibrotic drug, its main anti-fibrotic components are Calycosin, Astragaloside IV, Astragalus polysaccharides and formononetin. We also review formulas that contain Astragalus with anti-fibrotic effects, in which Astragalus and Salvia miltiorrhiza Bunge, Astragalus and Angelica sinensis (Oliv.) Diels are the most commonly used combinations. We propose that combining active components into new formulations may be a promising way to develop new drugs for fibrosis. Besides, we expect Astragalus to be accepted as a clinically effective method of treating fibrosis.

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Glabridin from Glycyrrhiza glabra Possesses a Therapeutic Role against Keloid via Attenuating PI3K/Akt and Transforming Growth Factor-β1/SMAD Signaling Pathways

Cited by 18 publications

References 33 publications

Keloids: A Review of the Diseases, Causes, and Current Treatments

Keloids: A Review of the Diseases, Causes, and Current Treatments

An updated review of the immunological mechanisms of keloid scars

Astragalus and its formulas as a therapeutic option for fibrotic diseases: Pharmacology and mechanisms

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