2023
DOI: 10.1186/s10020-023-00754-y
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Glabridin improves autoimmune disease in Trex1-deficient mice by reducing type I interferon production

Jincai Wen,
Wenqing Mu,
Hui Li
et al.

Abstract: Background The cGAS-STING signaling pathway is an essential section of the natural immune system. In recent years, an increasing number of studies have shown a strong link between abnormal activation of the cGAS-STING signaling pathway, a natural immune pathway mediated by the nucleic acid receptor cGAS, and the development and progression of autoimmune diseases. Therefore, it is important to identify an effective compound to specifically downregulate this pathway for disease. … Show more

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Cited by 5 publications
(1 citation statement)
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“…Glycyrrhizin has been shown to inhibit activation of the HMGB1/TLR9 pathway to alleviate sepsis-induced acute respiratory distress syndrome ( Zhao et al, 2016 ). In addition, licorice flavonoids, licorice extracts, Licochalcone B, and Glabridin have all been shown to have significant inhibitory effects on the cGAS-STING pathway and its mediated inflammatory disorders ( Wen et al, 2023a ; Wen et al, 2023b ; Luo et al, 2023 ; Luo et al, 2024 ). Therefore, we speculate that GUP, a major component of licorice, may also have an effect on the cGAS-STING pathway.…”
Section: Introductionmentioning
confidence: 99%
“…Glycyrrhizin has been shown to inhibit activation of the HMGB1/TLR9 pathway to alleviate sepsis-induced acute respiratory distress syndrome ( Zhao et al, 2016 ). In addition, licorice flavonoids, licorice extracts, Licochalcone B, and Glabridin have all been shown to have significant inhibitory effects on the cGAS-STING pathway and its mediated inflammatory disorders ( Wen et al, 2023a ; Wen et al, 2023b ; Luo et al, 2023 ; Luo et al, 2024 ). Therefore, we speculate that GUP, a major component of licorice, may also have an effect on the cGAS-STING pathway.…”
Section: Introductionmentioning
confidence: 99%