Glacial lake outburst floods (GLOF) hazards in alpine areas are increasing. The effects of climate change on GLOF hazards are unclear. This study examined 37 glacial lakes and climate data from 15 meteorological stations and explored the correlation between climate variations at different temporal scales. The results indicate that 19 GLOFs hazards occurred in El Niño (warm) years, 8 GLOFs hazards occurred in La Niña (cold) years, 3 GLOFs hazards occurred in cold/warm or warm/cold transition years, and 7 GLOFs hazards occurred in normal years. The higher the fluctuations, the higher the probability of GLOF hazards. Climatic conditions can be divided into three categories: extreme temperature and precipitation, as represented by the Guangxie Co GLOF; extreme precipitation, as represented by the Poge Co GLOF; and extreme temperature, as represented by the Tsho Ga GLOF.