Glandular Carcinoma of the Larynx: The Ucla Experience

Alavi, Sassan; Calcaterra, Thomas C.; Namazie, Ali; Blackwell, Keith E.

doi:10.1177/000348949910800512

Cited by 46 publications

(36 citation statements)

References 18 publications

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“…As accessory salivary glands are exiguous in the larynx, laryngeal ACC is a rare disease, accounting for <1% of all malignant tumors in this area (10). When ACC occurs in the supraglottis, it often involves the false cords, the aryepiglottic folds and the caudal aspect of the epiglottis.…”

Section: Discussionmentioning

confidence: 99%

Supraglottic adenoid cystic carcinoma mimicking laryngeal amyloidosis: A case report

Qian

Zhou

et al. 2014

Oncology Letters

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Abstract. Supraglottic adenoid cystic carcinoma (ACC) is extremely rare and may be misdiagnosed as laryngeal amyloidosis. The present report describes a case of supraglottic ACC, which went unrecognized until histopathological examination of the neoplasm 18 months after the first presentation. The present patient presented with progressive hoarseness for half a year and initially required partial resection. Following quick regional recurrence, the patient received a total laryngectomy while refusing radiotherapy. Adjuvant post-operational traditional Chinese medicine was accepted. Over 3 years' follow-up, there was no evidence of regional relapse or distant metastases. The present case is compared with a second case of supraglottic submucosal mass in which the signs, symptoms and examinations were similar to the first case, but that was diagnosed as laryngeal amyloidosis. Attention should be paid to submucosal masses in the larynx to prevent underlying malignancy and subsequent disease progression. Immunocytochemistry, such as p63 staining, is mandatory for making an early differential diagnosis of supraglottic ACC. Traditional Chinese medicine may be a useful adjuvant therapy for this rare disease.

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Section: Discussionmentioning

confidence: 99%

Supraglottic adenoid cystic carcinoma mimicking laryngeal amyloidosis: A case report

Qian

Zhou

et al. 2014

Oncology Letters

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“…For example, Alavi et al presented five patients treated with surgery alone or followed by adjuvant radiotherapy with 2-year survival of 100% and a 5-year survival of 75%. Cohen et al reported eight patients with similar treatment approaches, but high early survival of 87.5% at 2 years that dropped to 44.4% at 5 years [8,26]. Recent studies, such as Calzada et al, stratified patients based on treatment modality and provided complementary data on local regional control.…”

Section: Discussionmentioning

confidence: 99%

“…Laryngeal ACC is an extremely rare form of the neoplasm. The majority of instances of laryngeal ACC are located in the subglottic area, a minority of cases in the supraglottic area, and a relatively few have a glottic origin [7][8][9]. Diagnosis may be delayed because of the lack of symptoms in the early stages of the disease.…”

Section: Introductionmentioning

confidence: 99%

Organ Preservation for Adenoid Cystic Carcinoma of the Larynx

et al. 2013

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Objectives. Two cases of adenoid cystic carcinoma (ACC) of the larynx were treated with chemoradiotherapy (CRT) for organ preservation. We reviewed case series and current literature to contrast the potential role of primary CRT as an organsparing modality with standard laryngectomy and radiotherapy in patients with laryngeal ACC. Methods. Two treatment-naïve patients with laryngeal ACC treated at Dana-Farber Cancer Institute between 2002 and 2007 were identified. Both patients were offered standard laryngectomy followed by adjuvant radiotherapy or organsparing treatment modality. Results. Both patients were males, aged 57 and 73. The patients completed a course of combined chemoradiotherapy with weekly carboplatin and paclitaxel and 7-8 weeks of radiotherapy to a total dose of 6,600 and 7,000 cGy over 50 and 57 days, respectively. There were no treatment breaks or delays because of toxicity. The major toxicities reported by both patients, as anticipated, were Grade 3 mucositis, desquamative dermatitis, and severe dysphagia, all of which resolved. Both patients are alive with local regional control and functional larynx; one at 112ϩ months with pulmonary metastases at 54 months, and the other disease free at 60ϩ months. Conclusions. Definitive chemoradiation with weekly carboplatin and paclitaxel may be a potential alternative to the current standard of surgery and radiation for patients with locally advanced laryngeal ACC who request an organ-sparing approach. In this group of patients, salvage laryngectomy may be reserved for those who are locally recurrent or chemoradiotherapy resistant. Although CRT provided long-term local regional control in our two patients, there are evident limitations in obtaining evidence for a determination of treatment of rare diseases. This report provides support for following an organ preservation plan in selected patients. The Oncologist 2013;18:579 -583 Implications for Practice: Concurrent chemoradiotherapy may be used for larynx preservation for selected patients with adenoid cystic carcinoma of the larynx when the functional outcome after surgery is expected to be unsatisfactory or when surgical expertise in such procedures is not available. Laryngeal preservation with concurrent chemoradiotherapy with surgery reserved for recurrent disease seems to offer potential for laryngeal preservation without compromising overall survival. Selection of a treatment option: surgery versus organ-sparing chemoradiotherapy will depend on patient choice of treatment, local expertise, and the availability of appropriate support and rehabilitation services.

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“…Patients with MEC tend to present with locally advanced disease due to extensive submucosal tumor spread. 10 Mucoepidermoid carcinomas are formed by 3 cell types: squamous cells, mucous cells, and intermediate cells. 10 According to the ratio of solid to cystic elements, neural invasion, necrosis, mitosis, and cellular anaplasia tumors are classified as low, medium, or high grade.…”

Section: Discussionmentioning

confidence: 99%