Glandular fever-like syndrome, pulmonary eosinophilia and asthma associated with carbamazepine

Lewis, I; Rosenbloom, Lewis

doi:10.1136/pgmj.58.676.100

Cited by 27 publications

(5 citation statements)

References 6 publications

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“…CBZ has been reported to induce eosinophilic inflammations such as lung eosinophilia (Lee et al, 1981;Lewis et al, 1982), eosinophilic cholangitis (Larrey et al, 1987), and erythema multiforme (Meisel and North, 1984). In these cases, patients have also had eosinophilia in peripheral blood.…”

Section: Discussionmentioning

confidence: 99%

Carbamazepine‐Induced Eosinophilic Colitis

Anttila

Valtonen

1992

Epilepsia

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Section: Discussionmentioning

confidence: 99%

Carbamazepine‐Induced Eosinophilic Colitis

Anttila

Valtonen

1992

Epilepsia

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“…Carbamazepine hypersensitivity reactions may mimic viral infections, glandular fever, or pseudo-lymphoma. [1][2][3] Eosinophilia may occur as a part of carbamazepine hypersensitivity but leukemoid reaction secondary to carbamazepine therapy is very rare. A case of carbamazepine hypersensitivity associated with neutrophilic leukemoid reaction has been reported in literature.…”

Section: Introductionmentioning

confidence: 99%

Eosinophilic leukemoid reaction associated with carbamazepine hypersensitivity

Laad¹,

Miranda²

2005

Indian J Dermatol Venereol Leprol

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Carbamazepine is widely used in the treatment of epilepsy, neuralgic pain, and bipolar affective disorders. Several adverse drug reactions have been described during the course of carbamazepine administration, including exanthemata and hematological reactions. Carbamazepine is one of the common drugs that have been implicated in the etiology of drug hypersensitivity syndrome. A 50-year-old male presented with generalized erythroderma following 10 weeks of ingestion of carbamazepine 200 mg daily for idiopathic epilepsy. His systemic examination was within normal limits. Blood counts revealed marked eosinophilia of 52% (absolute eosinophil count of 10,400 per mm3). Bone marrow aspiration revealed a moderate increase in the eosinophilic series with cells showing normal morphology. The eosinophil counts returned to normal after 2 weeks of oral prednisolone therapy. This case is reported because of its rarity in the Indian medical literature.

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“…[4][5][6][7] Occurrence of asthma has also been reported with the use of carbamazepine. 8,9 Since drug hypersensitivity has been the postulated underlying mechanism, patients have usually been managed with withdrawal of the drug and administration of corticosteroids, although severe cases, wherein administration of carbamazepine was associated with the development of respiratory failure, have required mechanical ventilatory support in addition to other measures. 10 The authors' recommendation for the routine use of carbamazepine in persistent asthma on the basis of a single trial involving small number of patients in each group is at present, premature and unwarranted.…”

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confidence: 99%