Glandular odontogenic cyst: a rare entity revealed and a review of the literature

Anchlia, Sonal; Bahl, Sumit; Shah, Vandana; Vyas, Siddharth

doi:10.1136/bcr-2015-211502

Cited by 14 publications

(12 citation statements)

References 7 publications

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“…4,14,16,[20][21][22][23] Analysis of the expression of epithelial membrane antigen and mammary serine protease inhibitor (MASPIN) in doubtful cases of GOC can be helpful to distinguish between GOC and central MEC, demonstrating a minimal or a lack of expression in GOC cases. 16,18 Special stains, such as Periodic acid-Schiff, Mucicarmine and Alcian blue, have been used to identify and distinguish between clear or vacuolated cells and mucous cells. 5,14 On the other hand, immunohistochemical analysis could be an adjunct in the understanding of GOC behaviour.…”

Section: Discussionmentioning

confidence: 99%

“…In fact, the presence of prosoplasia in the cystic lining with mucous cells and ciliated cells highly mimics microscopic features of GOC 5 . The histopathological features of a low‐grade central MEC can overlap with the features of GOC 5,16–18 . Besides the microscopic similarities, central MEC also affects middle‐aged individuals and, when located within the mandible, it may cause bone expansion and produce a radiographic appearance of a well‐defined unilocular or multilocular radiolucency 19 …”

Section: Discussionmentioning

confidence: 99%

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Glandular odontogenic cysts: A collaborative investigation of 22 cases and proteins related to invasiveness

Silva

Gomes

Balbinot

et al. 2022

J Oral Pathology Medicine

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Background A glandular odontogenic cyst (GOC) has an intriguing, aggressive behaviour whose mechanisms have not yet been clarified. Objective To conduct a collaborative cross‐sectional study on the clinical, demographic, microscopic and immunohistochemical characteristics of GOCs, emphasizing the histopathological characteristics and expression of proteins related to invasiveness. Methods Twenty‐two cases of GOC from three oral and maxillofacial pathology services in Brazil were selected from 1988 to 2018. Clinical and demographic data were collected. Histopathological features were evaluated in detail. Sixteen cases of GOC were also submitted to immunohistochemistry to detect MT1‐MMP, TKS4, TKS5 and cortactin, the key regulators of invadopodia formation. Results Glandular odontogenic cysts were primarily seen in men over 40 years of age, in the posterior mandible and the anterior maxilla as a unilocular, radiolucent lesion. All cases presented hobnail cells, clear cells and variable thickness of the lining epithelium, 3 of the 10 key histopathological parameters to be evaluated in GOCs. Immunohistochemistry revealed a greater expression of the studied proteins in the GOCs than in the controls (p < 0.0001). Conclusion Overexpression of proteins that regulate cell invasiveness was identified, and the present study's findings suggest that invadopodia activity is a possible mechanism used by GOCs to promote local invasion, which could partly explain its intriguing biological behaviour.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Glandular odontogenic cysts: A collaborative investigation of 22 cases and proteins related to invasiveness

Silva

Gomes

Balbinot

et al. 2022

J Oral Pathology Medicine

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“…Chrcanovic e Gomez 14 (2017) ao analisarem 169 casos de COG, constaram uma taxa de recidiva de 21,6%. Afirmaram que procedimentos adjuvantes após a enucleação do cisto devem ser necessariamente considerados, destacando, por exemplo, a crioterapia, solução de Carnoy ou ostectomia periférica 14,15 . Neste estudo não houve terapias adjuvantes além da ostectomia periférica realizada, muito embora pudesse ser de interesse associá-las após a curetagem ou ostectomia finais 14 .…”

Section: Discussionunclassified

Cisto odontogênico glandular tratamento cirúrgico por marsupialização e enucleação: relato de caso

Oliveira

Cardoso

et al. 2021

Rev Odontol Bras Central

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O cisto odontogênico glandular (COG) é o cisto de desenvolvimento mais agressivo e raro dentre todos os odontogênicos, portando características epiteliais glandulares ou salivares. O presente artigo visa retratar uma abordagem mais conservadora para esta importante lesão, no sentido de minimizar a morbidade decorrente da abordagem mais radical. Paciente com 57 anos, leucoderma, assintomático e edêntulo, compareceu ao ambulatório de estomatologia com notável expansão no fundo de saco vestibular e rebordo inferior direito, com tempo indeterminado de evolução. Os exames imaginológicos revelaram uma lesão radiolúcida unilocular extensa e bem delimitada na região anterior da mandíbula. Nas condutas propedêuticas, foi realizada uma punção aspiratória positiva para líquido cístico seguido de biópsia incisional. Diante destes achados, a marsupialização foi realizada no sentido de se conseguir a redução das dimensões lesionais, seguido da enucleação com estectomia periférica após 9 meses. Nos primeiros 2 anos de proservação o paciente mantém-se sem recidivas e em constante acompanhamento. Conclui-se que o dentista pode preferir o método conservador pela técnica de marsupialização seguida de enucleação na abordagem de extenso cisto odontogênico glandular, desde que haja colaboração do paciente nos cuidados pós-operatórios.

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“…Some surgeons prefer marginal or segmental resection due to the tendency of GOC to recur after conservative treatment. [ 8 9 10 ] The rate of recurrence has been found to vary with its radiographic complexity. Patients with large multilocular lesions and cortical perforation show tendency for recurrence.…”

Section: Discussionmentioning

confidence: 99%

Glandular odontogenic cyst: Series of five cases

Urs

Kumar

Augustine

et al. 2017

J Oral Maxillofac Pathol

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Introduction:Glandular odontogenic cyst (GOC) is a clinically rare and histopathologically unusual type of developmental odontogenic cyst with unpredictable and potentially aggressive behaviour.Materials and Methods:Archival data of cases histopathologically identified as GOC were analyzed from the Department of Oral Pathology over the past six years. The clinical, radiographic, histopathological features and treatment were evaluated. Special stains such as periodic acid Schiff, mucicarmine along with immunohistochemical staining for cytokeratin 19 were employed to confirm the histopathological diagnosis.Results:The study indicated a strong female predilection with slightly more number of cases found in maxilla than mandible. Most cases showed a well defined multilocular radiolucency. The microscopic features which aid in its differentiation from its mimickers such as central mucoepidermoid carcinoma, lateral periodontal cyst, dentigerous cyst and botryoid odontogenic cyst which were observed included presence of variable thickness of the lining epithelium, epithelial plaques and whorls, hobnail cells, ciliated cells, clear cells and goblet cells.Conclusion:The present case series aims to throw light on the clinical, radiographic and microscopic features of GOC, which may aid in its definitive diagnosis in problematic cases.

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Glandular odontogenic cyst: a rare entity revealed and a review of the literature

Cited by 14 publications

References 7 publications

Glandular odontogenic cysts: A collaborative investigation of 22 cases and proteins related to invasiveness

Glandular odontogenic cysts: A collaborative investigation of 22 cases and proteins related to invasiveness

Cisto odontogênico glandular tratamento cirúrgico por marsupialização e enucleação: relato de caso

Glandular odontogenic cyst: Series of five cases

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