Glandular odontogenic cyst: case report and review of diagnostic criteria

Morais, Hécio Henrique Araújo de; Vasconcellos, Ricardo José de Holanda; Santos, Thiago de Santana; Queiroz, Lélia Maria Guedes; Silveira, Éricka Janine Dantas da

doi:10.1016/j.jcms.2011.03.018

Cited by 22 publications

(18 citation statements)

References 12 publications

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“…Various kinds of fluids may aspirate from this cyst. Krishnamurthy et al mentioned a clear, low-viscosity fluid on aspiration (Krishnamurthy et al, 2009); others have reported a brownish-red fluid on aspiration (Araújo de Morais et al, 2012). In one of our cases, aspiration was negative, whereas in two cases the lesion contained creamy, high-viscosity fluid.…”

Section: Discussionmentioning

confidence: 44%

“…It is not easy to identify the rate of success for any of the treatment modalities because of the low incidence of this lesion in the population and poor follow-up in previous studies. Araújo de Morais et al believed that follow-up visits should continue at least for 3 years after surgery, but most reported cases have been followed for 2 years or less (Araújo de Morais et al, 2012).…”

Section: Discussionmentioning

confidence: 99%

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Case series and review of glandular odontogenic cyst with emphasis on treatment modalities

Roochi¹,

Tavakoli²,

Ghazi³

et al. 2015

Journal of Cranio-Maxillofacial Surgery

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Section: Discussionmentioning

confidence: 44%

Section: Discussionmentioning

confidence: 99%

Case series and review of glandular odontogenic cyst with emphasis on treatment modalities

Roochi¹,

Tavakoli²,

Ghazi³

et al. 2015

Journal of Cranio-Maxillofacial Surgery

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“…Glandular odontogenic cyst (GOC) is an uncommon benign cystic lesion of the gnathic bones initially described in 1987 as ''sialo-odontogenic cyst'' or ''mucoepidermoid odontogenic cyst.'' [6][7][8][9][10][11][12][13][14][15][16] Since its first description, many investigators have recognized that GOC shares many histologic features with central MEC [1,2,5,7,9,10,[16][17][18][19][20]. Indeed, it is common to see areas indistinguishable from GOC within a central MEC [2].…”

Section: Introductionmentioning

confidence: 99%

Glandular Odontogenic Cysts (GOCs) Lack MAML2 Rearrangements: A Finding to Discredit the Putative Nature of GOC as a Precursor to Central Mucoepidermoid Carcinoma

Bishop

Yonescu

Batista

et al. 2014

Head and Neck Pathol

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Glandular odontogenic cyst (GOC) is a cyst of the gnathic bones that is characterized by squamous and glandular differentiation. The histopathologic features of GOC overlap considerably with central mucoepidermoid carcinoma (MEC), suggesting that GOC could be a precursor lesion to, or even a low-grade form of, central MEC. Differentiating the two lesions may be difficult or impossible on a limited biopsy. MAML2 rearrangements have been recently found to be specific for MEC, even those arising in the jaws. An analysis of MAML2 in GOCs could help clarify its relationship with central MEC. Tissue blocks from 21 GOCs and 5 central MECs were retrieved from the surgical pathology archives of The Johns Hopkins Hospital. Each MEC exhibited solid areas and clear-cut stromal invasion. In addition, 4 of the MECs demonstrated cystic areas that were histologically similar to GOC. Breakapart fluorescence in situ hybridization for MAML2 was performed. For the MECs, analysis was performed on both the solid components and the cystic areas that resembled GOC. MAML2 rearrangements were identified in all 5 of the MECs, but in none of the 21 GOCs (100 vs. 0 %; p \ 0.0001, Fisher's Exact). In the MECs, the rearrangement was present in both the solid and GOC-like cystic areas. While central MECs consistently harbor the MAML2 rearrangement, even in low-grade cystic areas that resemble a pre-existing GOC, true GOCs do not. Accordingly, GOC does not appear to represent an early or low-grade form of central MEC, but rather an unrelated lesion. The high sensitivity and specificity of MAML2 rearrangement for MECs points to its utility as a diagnostic adjunct in separating mucinous cystic lesions of the gnathic bones.

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“…Even when a tumor is detected randomly in the X-ray of the bone, with minimal facial asymmetry but without the presence of pain, it does not raise any concern in the patient. 6 The etiology of the glandular cyst is still not clear. In the literature, the link between GOCs and the salivary gland tissue has been primarily stressed.…”

Section: Introductionmentioning

confidence: 99%

Transformation of a glandular odontogenic cyst into mucoepidermoid carcinoma of the mandible: A case report

Dymek¹,

Książek²,

Lewandowski³

2019

Dent. Med. Probl.

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The glandular odontogenic cyst (GOC) is a rare pathology of odontogenic origin, which can behave unpredictably. It is problematic in clinical, radiographic and histological diagnostics. Intraosseous mucoepidermoid carcinoma (MEC) is a rare tumor which affects the jaws, typically found in the mandible. This malignancy, which usually originates from the salivary glands, can also be caused by a transformation of the mucous cells found in odontogenic cysts. This article presents a rare case of GOC transforming into MEC of the mandible, which was reported during the treatment of a 52-year-old male patient. The aim of this work was to present some of the therapeutic and clinical difficulties encountered when GOC transforms into mucoepidermoid cancer in the mandible, considering the pathomorphological and histological differentiations. The differentiation between MEC and GOC might be difficult through microscopic examination and requires the cooperation of a clinician-a maxillofacial surgeon-and a histo pathologist.

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Glandular odontogenic cyst: case report and review of diagnostic criteria

Cited by 22 publications

References 12 publications

Case series and review of glandular odontogenic cyst with emphasis on treatment modalities

Case series and review of glandular odontogenic cyst with emphasis on treatment modalities

Glandular Odontogenic Cysts (GOCs) Lack MAML2 Rearrangements: A Finding to Discredit the Putative Nature of GOC as a Precursor to Central Mucoepidermoid Carcinoma

Transformation of a glandular odontogenic cyst into mucoepidermoid carcinoma of the mandible: A case report

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