Glandular Odontogenic Cyst: Report of Two Cases and Review of Literature

Anuthama, Krishnamurthy; Sherlin, Herald J; Ramalingam, Karthikeyan; Natesan, Anuja; Premkumar, Priya; Ramani, Pratibha; Chandrasekar, Thiruvengadam

doi:10.1007/s12105-009-0117-2

Cited by 96 publications

(95 citation statements)

References 35 publications

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“…Many of these have been single case reports; however, several short series and detailed reviews of the literature have also been published [1,2,6,7,11,[13][14][15][16][17][18][19][20][21][22][23][24][25][26]. Therefore, the GOC, though rare, is now relatively well known, especially among oral and head and neck pathologists.…”

Section: Discussionmentioning

confidence: 99%

Glandular Odontogenic Cyst: Analysis of 46 Cases with Special Emphasis on Microscopic Criteria for Diagnosis

Fowler

Brannon

Kessler

et al. 2011

Head and Neck Pathol

133

172

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The glandular odontogenic cyst (GOC) is now a relatively well-known entity with recent reviews indicating over 100 cases reported in the English literature. The GOC's importance relates to the fact that it exhibits a propensity for recurrence similar to the odontogenic keratocyst, and that it may be confused microscopically with central mucoepidermoid carcinoma (CMEC). Numerous histopathologic features for the GOC have been described, but the exact microscopic criteria necessary for diagnosis have not been universally accepted. Furthermore, some of the microscopic features of GOC may also be found in dentigerous, botryoid, radicular, and surgical ciliated cysts. The purpose of this multicenter retrospective study is to further define the clinical, radiographic, and microscopic features of GOC, to determine which microscopic features may be helpful for diagnosis in problematic cases, to determine the most appropriate treatment, and to determine if GOC and CMEC share a histopathologic spectrum. In our series of 46 cases, the mean age at diagnosis was 51 years with 71% of cases in the 5th-7th decades. No gender predilection was noted. 80% of cases occurred in the mandible, and 60% of the lesions involved the anterior regions of the jaws. Swelling/expansion was the most common presenting complaint, although some cases were asymptomatic. Radiographically, most cases presented as a well-defined unilocular or multilocular radiolucency involving the periapical area of multiple teeth. Some lesions displayed a scalloped border. Cases also presented in dentigerous, lateral periodontal, and ''globulomaxillary'' relationships. The canine area was a common location for maxillary cases. All cases were treated conservatively (enucleation, curettage, cystectomy, excision). Follow-up on 18 cases revealed a recurrence rate of 50% (9/18), with 6 cases recurring more than once (range of follow-up: 2 months to 20 years; average length of follow-up: 8.75 years). The mean interval from initial treatment to first recurrence was 8 years, and from first recurrence to second recurrence was 5.8 years. Two cases recurred three times and the interval from second to third recurrence was 7 years (exact interval only documented in one case). All cases exhibited eosinophilic cuboidal (hobnail) cells, a feature not specific for GOC, but necessary for diagnosis, in our opinion. Univariate analysis indicated several features that are most helpful in distinguishing GOC from GOC mimickers in problematic cases, including: (1) the presence of microcysts (P \ 0.0001); (2) epithelial spheres 123Head and Neck Pathol (2011) 5:364-375 DOI 10.1007 (P \ 0.0001); (3) clear cells (P = 0.0002); (4) variable thickness of the epithelial cyst lining (P = 0.0002); and (5) multiple compartments (P = 0.006). Stratified analysis indicated that when microcysts are present, epithelial spheres and multiple compartments are still significant, and clear cells are marginally significant in distinguishing GOCs from GOC mimickers. The presence of microcysts (P = 0.00...

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Section: Discussionmentioning

confidence: 99%

Glandular Odontogenic Cyst: Analysis of 46 Cases with Special Emphasis on Microscopic Criteria for Diagnosis

Fowler

Brannon

Kessler

et al. 2011

Head and Neck Pathol

133

172

View full text Add to dashboard Cite

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“…LPC is a developmental cyst and odontogenic in origin lined by thin non-keratinized squamous epithelium and also exhibits focal epithelial thickenings and glycogen-rich epithelial cells, comparable to those seen in GOC's. [2] 2. BOC is a locally destructive polycystic variant of LPC, shows alike histomorphologic features with those of GOC, such as areas of glycogen-rich clear cells and epithelial plaques.…”

Section: Discussionmentioning

confidence: 99%

“…Radiologically, they might show unilocular or multilocular radiolucency with a distinct border. [2] Histologically, GOC is characterized by a cystic lining of non-keratinized epithelium, mucous fi lled clefts, with papillary projections, nodular thickenings, and "mucous lakes." It also includes vacuolated cuboidal basal cells.…”

Section: Introductionmentioning

confidence: 99%

Glandular odontogenic cyst associated with an impacted maxillary canine: A rare case report

Vanishree¹,

Hunasgi²,

Koneru³

et al. 2016

IJMDCR

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Glandular odontogenic cyst (GOC) is a rare developmental odontogenic cyst of the oral cavity. The most common site of occurrence for GOC is a mandibular anterior region, presenting typically in the middle age and has a minor male predilection. This article presented a case of GOC and focused on the review of clinico-pathologic features of the lesions considered in the diff erential diagnosis. A 17-year-old female patient reported with pain and swelling in the right upper front tooth region since 8 months. Radiographically, a well-defi ned unilocular radiolucency is seen in relation to impacted right maxillary canine. A provisional diagnosis of the dentigerous cyst was given. The excised tissue revealed a stratifi ed squamous epithelial lining exhibiting cuboidal cells with goblet cells which are numerous and foci of epithelial cells presenting with eosinophilic material resembling mucin. The present case was associated with an impacted maxillary canine, which is found to be a very rare location for GOC. Thus, this case report of GOC will add to the existing knowledge of rare cysts.

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“…이것은 중년, 하악에 호발하는 경향을 가지며, 임상 적 특징으로 피질골의 천공, 치근흡수의 국소적으로 공격 적인 양상을 특징으로 하며 환자는 보통 무통성의 종창을 우연히 발견하게 된다 [1][2][3] . 크기는 0.5-12 cm으로 다양한 경 향을 나타내며.…”

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“…방사선학적으로는 다방성의 방사선투과성을 특징으로 한다 [1][2][3] . 조직병리학적으로는 특징적으로 상피세 포구, 상피세포층 내의 점액세포, 위도관 구조의 세포배열 을 특징으로 한다 [1][2][3][4] Glandular odontogenic cyst (GOC) is an intraoral cyst originated from serre remnants which has incidence of rare frequency. Only 111 cases have been reported since Gardener first introduced it in 1987.…”

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