Glandular odontogenic cyst with hyaline bodies: an unusual dentigerous presentation

Ide, Fumio; Shimoyama, Tetsuo; Horie, Norio

doi:10.1111/j.1600-0714.1996.tb00286.x

Cited by 36 publications

(19 citation statements)

References 18 publications

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“…Such gland-like structures, which have not been demonstrated previously, resembled the glandular structures in "glandular odontogenic cysts (GOCs)", which are defined as cysts arising in tooth-bearing areas of the jaws that are lined with cuboidal to columnar epithelial cells containing mucous and/or ciliated cells and that exhibit crypt-like and microcystic spaces often lined with mucous cells (2,9). The formation of the intraepithelial gland-like structures observed in the present study, in addition to the rare presence of hyaline bodies and ghost cells in the epithelial lining of GOCs (10,11) and the multiple ductlike structures in the reduced enamel epithelia of compound odontoma (12), supports the notion that GOCs are odontogenic in origin, rather than originating from intraosseous ectopic salivary glands. The histochemical nature of mucous cells in the epithelial linings of odontogenic cysts is currently being investigated and will be reported in a future paper.…”

Section: Discussionsupporting

confidence: 86%

Mucous and ciliated cell metaplasia in epithelial linings of odontogenic inflammatory and developmental cysts

et al. 2005

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The incidence of mucous and ciliated cells in epithelial linings was examined among odontogenic inflammatory cysts (radicular cysts) and developmental cysts (dentigerous and primordial cysts).Mucous cells were found in 20.8% of all cysts examined, while ciliated cells were found in 11.4%; however, ciliated cells were always accompanied by mucous cells. The incidence of mucous cells in radicular cysts and dentigerous cysts and that of ciliated cells in radicular cysts was higher in the maxilla than in the mandible, while the incidence of mucous cells in primordial cysts and that of ciliated cells in dentigerous cysts and primordial cysts was higher in the mandible than in the maxilla.

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Section: Discussionsupporting

confidence: 86%

Mucous and ciliated cell metaplasia in epithelial linings of odontogenic inflammatory and developmental cysts

et al. 2005

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“…Table 3 indicates that 8 cases of GOC were associated with an unerupted tooth (dentigerous relationship). This was an unexpected finding because the majority of reported cases of GOCs are not associated with unerupted teeth, as only 6 such cases have been previously reported [6,21,22,29,30]. Moreover, because some of the microscopic features of GOC are similar if not identical to metaplastic changes in dentigerous cysts, rendering a diagnosis of GOC for a cyst in a dentigerous relationship should be done with caution.…”

Section: Discussionmentioning

confidence: 86%

Glandular Odontogenic Cyst: Analysis of 46 Cases with Special Emphasis on Microscopic Criteria for Diagnosis

Fowler

Brannon

Kessler

et al. 2011

Head and Neck Pathol

133

172

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The glandular odontogenic cyst (GOC) is now a relatively well-known entity with recent reviews indicating over 100 cases reported in the English literature. The GOC's importance relates to the fact that it exhibits a propensity for recurrence similar to the odontogenic keratocyst, and that it may be confused microscopically with central mucoepidermoid carcinoma (CMEC). Numerous histopathologic features for the GOC have been described, but the exact microscopic criteria necessary for diagnosis have not been universally accepted. Furthermore, some of the microscopic features of GOC may also be found in dentigerous, botryoid, radicular, and surgical ciliated cysts. The purpose of this multicenter retrospective study is to further define the clinical, radiographic, and microscopic features of GOC, to determine which microscopic features may be helpful for diagnosis in problematic cases, to determine the most appropriate treatment, and to determine if GOC and CMEC share a histopathologic spectrum. In our series of 46 cases, the mean age at diagnosis was 51 years with 71% of cases in the 5th-7th decades. No gender predilection was noted. 80% of cases occurred in the mandible, and 60% of the lesions involved the anterior regions of the jaws. Swelling/expansion was the most common presenting complaint, although some cases were asymptomatic. Radiographically, most cases presented as a well-defined unilocular or multilocular radiolucency involving the periapical area of multiple teeth. Some lesions displayed a scalloped border. Cases also presented in dentigerous, lateral periodontal, and ''globulomaxillary'' relationships. The canine area was a common location for maxillary cases. All cases were treated conservatively (enucleation, curettage, cystectomy, excision). Follow-up on 18 cases revealed a recurrence rate of 50% (9/18), with 6 cases recurring more than once (range of follow-up: 2 months to 20 years; average length of follow-up: 8.75 years). The mean interval from initial treatment to first recurrence was 8 years, and from first recurrence to second recurrence was 5.8 years. Two cases recurred three times and the interval from second to third recurrence was 7 years (exact interval only documented in one case). All cases exhibited eosinophilic cuboidal (hobnail) cells, a feature not specific for GOC, but necessary for diagnosis, in our opinion. Univariate analysis indicated several features that are most helpful in distinguishing GOC from GOC mimickers in problematic cases, including: (1) the presence of microcysts (P \ 0.0001); (2) epithelial spheres 123Head and Neck Pathol (2011) 5:364-375 DOI 10.1007 (P \ 0.0001); (3) clear cells (P = 0.0002); (4) variable thickness of the epithelial cyst lining (P = 0.0002); and (5) multiple compartments (P = 0.006). Stratified analysis indicated that when microcysts are present, epithelial spheres and multiple compartments are still significant, and clear cells are marginally significant in distinguishing GOCs from GOC mimickers. The presence of microcysts (P = 0.00...

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“…This cyst has a tendency to recur after enucleation, giving a rate of recurrence of approximately 20% (43,44). The concept of an odontogenic origin is lent by the occurrence of hyaline bodies (45), ghost cells (43,46), squamous odontogenic tumor-like proliferations (46,47), and dentinoid (44) in the wall of cyst, in addition to a GOC presenting as a dentigerous cyst (45).…”

Section: Hybrid Tumor Of Ameloblastoma and Glandular Odontogenic Cystmentioning

confidence: 99%

So-called Hybrid Odontogenic Tumors: Do they really exist?

et al. 2001

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Glandular odontogenic cyst with hyaline bodies: an unusual dentigerous presentation

Cited by 36 publications

References 18 publications

Mucous and ciliated cell metaplasia in epithelial linings of odontogenic inflammatory and developmental cysts

Mucous and ciliated cell metaplasia in epithelial linings of odontogenic inflammatory and developmental cysts

Glandular Odontogenic Cyst: Analysis of 46 Cases with Special Emphasis on Microscopic Criteria for Diagnosis

So-called Hybrid Odontogenic Tumors: Do they really exist?

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