Glandular Odontogenic Cyst with Metaplastic Cartilage: Report of an Unusual Case and Literature Review

Abstract

Glandular odontogenic cysts are rare odontogenic cysts with a wide range of histopathological features. In this paper we describe the clinical and pathological features of an unusual case of a glandular odontogenic cyst with metaplastic cartilage. The previous literature of odontogenic cysts presenting with metaplastic cartilage is reviewed alongside a discussion of the differential diagnoses. To our knowledge this is the first reported case of a glandular odontogenic cyst with metaplastic cartilage.

Clinical and radiologic spectrum of glandular odontogenic cysts: A multicenter study of 92 cases

“…GOC is a relatively uncommon entity, representing only 0.2% of all odontogenic cysts. 17 Fewer than 250 cases have been reported in the literature 3,5,[18][19][20] , with the largest single study sample comprising 46 cases. 4 To the authors' knowledge, the current study represents the largest sample size reported in a single study, excluding reviews of the literature.…”

Scalloped border as a possible diagnostic aid for differentiating jaw lesions: A pictorial essay

“…Glandular odontogenic cyst is a rare, locally aggressive odontogenic cyst that is also known as sialo-odontogenic cyst, developmental odontogenic epithelial cyst, and polymorphous odontogenic cyst. 26 27 It tends to occur over a wide age range, with most cases diagnosed in the fifth to seventh decades of life. 26 There is either a slight male predominance or no sex predilection.…”

“… 26 27 It tends to occur over a wide age range, with most cases diagnosed in the fifth to seventh decades of life. 26 There is either a slight male predominance or no sex predilection. 26 28 The mandible is more affected than the maxilla, and most cases are seen in the anterior portion of the jaw.…”

“… 26 There is either a slight male predominance or no sex predilection. 26 28 The mandible is more affected than the maxilla, and most cases are seen in the anterior portion of the jaw. 28 Clinically, it usually presents as an asymptomatic, slow-growing, invasive lesion with considerable expansion; however, the presence of clinical symptoms has been reported in 24% of cases.…”

“… 5 6 7 8 9 In contrast, a unilocular or multilocular radiolucency with scalloped borders extending from the mesial aspect of the mandibular first molar to the midline with expansion or fullness of the vestibule might prompt consideration of central giant cell granuloma as the most probable diagnosis and glandular odontogenic cyst as a less likely diagnosis due to its lower prevalence. 10 12 26 33 When a clinician faces an extended multilocular radiolucent lesion with a scalloped border, but with minimal expansion, he or she should put forward the diagnosis of odontogenic keratocyst. 16 In another instance, simple bone cyst should be ranked first in the differential diagnosis when a solitary or multiple radiolucent lesions in the posterior aspect of the jaws is discovered on routine examination with scalloped borders with a possible history of trauma.…”