Glanzmann's Thrombasthenia Type II in a Saudi Child: A Case Report

Bahakim, Hassan M.; Al‐Eissa, Youssef A.; Kurbaan, Khadija M.

doi:10.5144/0256-4947.1990.333

Cited by 1 publication

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“…Both afibrinogenemia 15 and dysfibrinogenemia 17 have been reported recently from our institute and these were included in the current analysis. Again, more detailed chemical analysis of the fibrinogen molecule could not be performed locally to identify the molecular/structural abnormalities of the fibrinogen molecule.…”

Section: Discussionmentioning

confidence: 99%

Hereditary Bleeding Disorders in Riyadh, Saudi Arabia

et al. 1996

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The result of an eight-year retrospective analysis of patients with hereditary bleeding disorders (HBD) at King Khalid University Hospital, Riyadh, is presented. One hundred and sixty-eight patients referred for investigation for suspected bleeding disorders had bleeding symptoms which fulfilled the criteria for HBD and were categorized as follows: 1) coagulation factor deficiencies: 41 patients had hemophilia A, while 16 had hemophilia B; two patients each had factors XI and XII deficiency; four patients each had factors V and VIII deficiency and one patient had factor VII deficiency. There were two patients with dysfibrinogenemias and one with afibrinogenemia. 2) Von Willebrand's disease was the second most common cause of HBD-25 patients were encountered in 15 different families. 3) Qualitative platelet disorders consisted of Glanzmann's thrombasthenia, with 18 patients, BernardSoulier disease, with five patients, and other qualitative platelet disorders, with 33 patients. 4) In 14 patients who presented with a history of bleeding, the only abnormality noted was prolongation of the bleeding time and normal coagulation and platelet function, and no definitive diagnoses could be established. The distribution of hereditary bleeding disorders obtained in this study resembles what has already been established in Western countries, with the exception of an increase of platelet disorders, mostly due to the increased rate of consanguinity in the community.

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Section: Discussionmentioning

confidence: 99%