Glasgow prognostic score after concurrent chemoradiotherapy is a prognostic factor in advanced head and neck cancer

Chang, Pei‐Hung; Wang, Cheng‐Hsu; Chen, Eric Yen-Chao; Yang, Shih‐Wei; Chou, Wen‐Chi; Hsieh, Jason Chia‐Hsun; Kuan, Feng‐Che; Yeh, Kun‐Yun

doi:10.21147/j.issn.1000-9604.2017.03.02

Cited by 10 publications

(10 citation statements)

References 20 publications

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“…A number of studies have also found similar results for the prognostic role CAR or GPS in various types of cancers. [7][8][9][45][46][47][48][49][50][51][52][53][54][55][56][57][58][59][60][61][62] This highlighted the general prognostic role of these two inflammation-based scores in malignancies.…”

Section: Discussionmentioning

confidence: 99%

Prognostic Value of Inflammation Biomarkers for Survival of Patients with Neuroblastoma

Chen

Liu

Feng

et al. 2020

CMAR

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The prognostic significance of inflammation-based biomarkers for neuroblastoma (NB) has not been investigated before. The aim of this study was to evaluate the prognostic value of pre-treatment inflammation biomarkers in children patients with NB. Patients and Methods: Patients diagnosed with NB from 2008 to 2016 in our institution were enrolled in this study. The clinical data and survival outcomes were retrospectively reviewed. Inflammation biomarkers or scores including C-reactive protein (CRP), albumin (ALB), Glasgow Prognostic Score (GPS), modified Glasgow Prognostic Score (mGPS), high-sensitivity modified Glasgow Prognostic Score (Hs-mGPS), neutrophil to lymphocyte ratio (NLR), platelet to lymphocyte ratio (PLR), lymphocyte to monocyte ratio (LMR) and system inflammation index (SII) were tested in this study. Univariate and multivariate survival analyses were performed to assess the prognostic value of these inflammation indicators for overall survival (OS) of children with NB. Kaplan-Meier survival curves were also conducted. Results: A total of 70 children diagnosed with neuroblastoma were enrolled in this study. NLR, PLR, LMR and SII were found to be not predictive of OS for NB patients. However, CRP, ALB, GPS and CAR were significantly associated with OS of NB patients. Multivariate analysis adjusting for age, sex, histology, tumor size, tumor stage and metastasis revealed that ALB, CAR, GPS and Hs-mGPS were significantly associated with OS of NB patients. Receiver operating characteristic (ROC) curves and Akaike Information Criterion (AIC) analyses revealed that Hs-mGPS is superior to other inflammation biomarkers in predicting OS of NB patients. Subgroup survival analysis for immature NB patients revealed similar results. Conclusion: Hs-mGPS is an effective prognostic factor for OS of patients with NB and is promising to be used as a factor for risk stratification and an indicator for more aggressive therapy.

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Section: Discussionmentioning

confidence: 99%

Prognostic Value of Inflammation Biomarkers for Survival of Patients with Neuroblastoma

Chen

Liu

Feng

et al. 2020

CMAR

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“…In particular, several common peripheral blood-derived inflammation-based scores, such as the Glasgow Prognostic Score (GPS), NLR, and PLR, have been demonstrated as promising prognostic predictors in various malignancies. 26 – 28 However, the measurement of serum C-reactive protein was not routinely taken in our hospital before 2005, and therefore, the prognostic value of GPS was not examined in the current study.…”

Section: Discussionmentioning

confidence: 99%

A cumulative score based on preoperative fibrinogen and the neutrophil–lymphocyte ratio to predict outcomes in resectable gastric cancer

Liu

Lin

et al. 2018

CMAR

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BackgroundRecent studies have revealed that preoperative fibrinogen and the neutrophil–lymphocyte ratio (NLR) are associated with poor outcome in gastric cancer (GC). We aimed to evaluate whether the fibrinogen and the NLR score had a consistent prognostic value for resectable GC.MethodsWe analyzed 1,293 consecutive patients who underwent curative surgery for GC. The F-NLR score was 2 for patients with hyperfibrinogenemia (>400 mg/dL) and elevated NLR (≥5.0), 1 for those with one abnormal index, and 0 for those with no abnormal indices.ResultsWe found that higher F-NLR scores were associated with larger tumor size, deeper tumor invasion and more lymph node metastasis (all P<0.05). In a multivariate analysis, F-NLR independently predicted postoperative survival (P<0.001). When stratified by tumor–node–metastasis (TNM) stage, the prognostic value of F-NLR was still maintained for stages I–II (P<0.001) and stage III (P=0.003). Of note, F-NLR also effectively stratified overall survival (OS) irrespective of age, adjuvant chemotherapy administration, tumor location and histological grade (all P<0.05). Furthermore, F-NLR and TNM stratified 5-year OS from 61% (F-NLR 0) to 15% (F-NLR 2) and from 92% (stage I) to 37% (stage III), respectively. Utilizing both F-NLR and TNM, 5-year OS ranged from 93% (F-NLR 0, TNM I) to 6% (F-NLR 2, TNM III).ConclusionThe F-NLR score independently predicts outcomes in GC patients after curative surgery. Therefore, it should be implemented in routine clinical practice for identifying more high-risk patients.

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“…Changes in the mGPS score prior to, during, and after CCRT have been identified as important prognosticators of DFS and OS. Patients exhibiting an improved GPS at the end of treatment have been linked to better OS (p= 0.013) and relapse-free survival (p=0.012) compared with those yielding a worsened final GPS 21…”

Section: Patient-related Factorsmentioning

confidence: 99%

Competing Morbidities In Advanced Head And Neck Squamous Cell Carcinoma Concurrent Chemoradiotherapy: A Strong Implication Of A Multidisciplinary Team Approach

Lazzari

Cillis

Buccoliero

et al. 2019

CMAR

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Concurrent chemoradiotherapy (CCRT) is the standard approach for the treatment of locally advanced head and neck squamous cell carcinoma. Despite its undisputed advantages, CCRT is associated with acute and late toxicities, leading to unfavorable implications (eg, unplanned interruptions and noncancer-related mortality). The former prolongs the overall treatment time leading to a detrimental effect on tumor control. The latter consists of several noncancer morbidities arising from treatment-related toxicities, identifying a new pathway in cancer fate. This pathway has been termed noncancer mortality or competing mortality and consists of a series of treatment-competing morbidities, which nullify all therapeutic efforts aimed at curing these patients. The management of patients with head and neck squamous cell carcinoma who experience treatment-related toxicities is complex and requires expertise in oncological treatment as well as supportive care. The optimal management of these patients should start with knowledge regarding the most important competing morbidities developing during all phases of the disease (ie, from diagnosis to follow-up) to minimize treatment interruptions, ensure appropriate psychological support, and achieve the best oncological result. The purpose of the present review is to analyze the most important competing morbidities due to patient’s condition at baseline and CCRT, which could result in noncancer mortality. A multidisciplinary team approach is strongly required in the management of this disease.

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Glasgow prognostic score after concurrent chemoradiotherapy is a prognostic factor in advanced head and neck cancer

Cited by 10 publications

References 20 publications

<p>Prognostic Value of Inflammation Biomarkers for Survival of Patients with Neuroblastoma</p>

<p>Prognostic Value of Inflammation Biomarkers for Survival of Patients with Neuroblastoma</p>

A cumulative score based on preoperative fibrinogen and the neutrophil–lymphocyte ratio to predict outcomes in resectable gastric cancer

<p>Competing Morbidities In Advanced Head And Neck Squamous Cell Carcinoma Concurrent Chemoradiotherapy: A Strong Implication Of A Multidisciplinary Team Approach</p>

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Glasgow prognostic score after concurrent chemoradiotherapy is a prognostic factor in advanced head and neck cancer

Cited by 10 publications

References 20 publications

<p>Prognostic Value of Inflammation Biomarkers for Survival of Patients with Neuroblastoma</p>

<p>Prognostic Value of Inflammation Biomarkers for Survival of Patients with Neuroblastoma</p>

A cumulative score based on preoperative fibrinogen and the neutrophil&ndash;lymphocyte ratio to predict outcomes in resectable gastric cancer

<p>Competing Morbidities In Advanced Head And Neck Squamous Cell Carcinoma Concurrent Chemoradiotherapy: A Strong Implication Of A Multidisciplinary Team Approach</p>

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A cumulative score based on preoperative fibrinogen and the neutrophil–lymphocyte ratio to predict outcomes in resectable gastric cancer