Glasgow Prognostic Score as a Prognostic Factor in Patients Undergoing Curative Surgery for Colorectal Cancer

Sugimoto, Kiichi; Komiyama, Hiromitsu; Kojima, Yutaka; Goto, Michitoshi; Tomiki, Yuichi; Sakamoto, Kazuhiro

doi:10.1159/000346002

Cited by 36 publications

(24 citation statements)

References 32 publications

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“…There were 8 studies reporting the relationship between the level of GPS and TNM stage 16–18, 20, 21, 23, 27, 29 . The combined odds ratio (OR) of 1.44 (95% CI: 1.010–2.065, P = 0.044) displayed that patients with elevated GPS was prone to be in advanced TNM stages, with no significant heterogeneity ( I 2 = 38.5%, P = 0.123; Fig.…”

Section: Resultsmentioning

confidence: 99%

Prognostic role of Glasgow prognostic score in patients with colorectal cancer: evidence from population studies

Liu

Pan

et al. 2017

Sci Rep

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Glasgow prognostic score (GPS) has been reported to be an indicator of prognosis for various cancers. However, the relationship between GPS and colorectal cancers (CRC) remains unclear. A comprehensive search of Pubmed, Embase, Cochrane library, Web of Science, ChinaInfo and Chinese National Knowledge Infrastructure was performed to identify eligible studies, from which the risk of overall survival (OS) and cancer-specific survival (CSS) were extracted. A random-effect model was adopted to combine hazard ratio (HR) and 95% confidence interval (CI). 25 articles with a total of 5660 participants were included. The pooled results indicated that elevated GPS was associated with poor OS (HR = 2.83, 95%CI: 2.00–4.00, P < 0.01) and CSS (HR = 1.94, 95%CI: 1.51–2.49, P < 0.01). This correlation was confirmed both in primary operable and advanced inoperable patients. Increased GPS was also closely related to advanced tumour-node-metastasis (TNM) stage (odds ratio [OR] = 1.44, 95% CI: 1.010–2.065, P < 0.05) and elevated level of serum carcinoembryonic antigen (OR = 2.252, 95% CI: 1.508–3.362, P < 0.01). Subgroup analysis revealed a significant association between high GPS and poor survival outcome according to the factors of sample size, study of region and cut-off value of GPS level. These findings suggest that GPS may serve as a reliable predictive index for patients with CRC.

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Section: Resultsmentioning

confidence: 99%

Prognostic role of Glasgow prognostic score in patients with colorectal cancer: evidence from population studies

Liu

Pan

et al. 2017

Sci Rep

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“…Previous studies demonstrated that the systemic inflammatory response-related factors including GPS, NLR and PNI were prognostic indicators in various cancers, because they reflect the tumor microenvironment, which are regarded as host-related factors induced by the tumor [9,[29][30][31][32]. Based on multivariate analysis in this study, we found that high ALP level is an independent factor to predict poor prognosis in advanced gastric cancer patients in addition to the traditional prognostic markers such as diffuse-type histology and further invaded tumor.…”

Section: Discussionmentioning

confidence: 99%

Prognostic significance of serum alkaline phosphatase and lactate dehydrogenase levels in patients with unresectable advanced gastric cancer

Namikawa¹,

Ishida²,

Tsuda³

et al. 2018

Gastric Cancer

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Background This study evaluated the prognostic value of alkaline phosphatase (ALP) and lactate dehydrogenase (LDH) together with host-related factors in patients with unresectable advanced gastric cancer. Methods The study enrolled 262 patients who received chemotherapy for unresectable advanced gastric cancer at Kochi Medical School from 2007 to 2015. Clinicopathological information and systemic inflammatory response data were analyzed for associations between baseline cancer-related prognostic variables and survival outcomes. Results The median survival time was significantly lower for patients with high ALP, high LDH, high total bilirubin, high aspartate aminotransferase, high alanine transaminase, high gamma-glutamyltransferase, high creatinine, a Glasgow prognostic score (GPS) of 1 or 2 score compared to GPS 0, higher compared to lower neutrophil to lymphocyte ratio (NLR) 3.9, lower compared to higher prognostic nutrition index 36.1, T3-4 compared to T1-2 tumor and diffuse-type compared to intestinaltype histology. Multivariate survival analysis identified high ALP 322 (HR 1.808; 95% CI 1.015-3.220; P = 0.044), T2-3 (HR 2.622; 95% CI 1.224-5.618; P = 0.013), and diffuse-type gastric cancer (HR 2.325; 95% CI 1.341-4.032; P = 0.003) as significant independent predictors of worse prognosis in the studied group of cancer patients. Conclusions High level of ALP is an independent, worse prognosis factor for patients receiving chemotherapy for unresectable and recurrent gastric cancer.

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“…Furthermore, recent studies have demonstrated that an elevated peripheral neutrophil to lymphocyte ratio (NLR) could be a poor prognostic indicator in various cancers [7,8] . Although the mechanism by which systemic inflammation could influence survival is not clear, it is believed that systemic inflammatory response-related factors reflect the tumor microenvironment, including tumor versus host interactions, and are thus regarded as host-related factors induced by the tumor [9] .…”

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confidence: 99%

Evaluation of Systemic Inflammatory Response Biomarkers in Patients Receiving Chemotherapy for Unresectable and Recurrent Advanced Gastric Cancer

Namikawa¹,

Munekage²,

Munekage³

et al. 2016

Oncology

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Background: The present study sought to evaluate an inflammation-based prognostic score (Glasgow prognostic score, GPS) and the neutrophil to lymphocyte ratio (NLR) as prognostic factors in patients receiving chemotherapy for advanced gastric cancer. Methods: The study enrolled 224 patients who received chemotherapy for advanced gastric cancer at the Kochi Medical School from 2007 to 2014. Clinicopathological information and systemic inflammatory response data were obtained to investigate associations between baseline cancer-related prognostic variables and survival outcomes. Results: The median survival time was significantly higher for patients with intestinal-type compared to diffuse-type histology (p = 0.039), a GPS 0 score compared to GPS 1 or 2 score (p = 0.004), and lower compared to higher NLR 4 (p = 0.002). Multivariate survival analysis identified high NLR 4 (HR 1.651; 95% CI 1.187-2.297; p = 0.003) and diffuse-type histology (HR 1.645; 95% CI 1.025-2.639; p = 0.039) as significant independent predictors associated with worse prognosis in the studied group of cancer patients. Conclusions: NLR and histological type are independent prognostic factors for patients receiving chemotherapy for unresectable and recurrent gastric cancer.

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Glasgow Prognostic Score as a Prognostic Factor in Patients Undergoing Curative Surgery for Colorectal Cancer

Cited by 36 publications

References 32 publications

Prognostic role of Glasgow prognostic score in patients with colorectal cancer: evidence from population studies

Prognostic role of Glasgow prognostic score in patients with colorectal cancer: evidence from population studies

Prognostic significance of serum alkaline phosphatase and lactate dehydrogenase levels in patients with unresectable advanced gastric cancer

Evaluation of Systemic Inflammatory Response Biomarkers in Patients Receiving Chemotherapy for Unresectable and Recurrent Advanced Gastric Cancer

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