Glass-ceramics for cancer treatment: So close, or yet so far?

Miola, Marta; Pakzad, Yousef; Banijamali, Sara; Kargozar, Saeid; Brovarone, Chiara Vitale; Yazdanpanah, Abolfazl; Bretcanu, Oana; Ramedani, Arash; Verné, Enrica; Mozafari, Masoud

doi:10.1016/j.actbio.2018.11.013

Cited by 105 publications

(55 citation statements)

References 96 publications

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“…BG have been used not only in regenerating hard tissues (e.g., bone, teeth) (Jones, 2015), but also in the repair of soft tissues (Miguez-Pacheco et al, 2015) and cancer treatment (Miola et al, 2018). For example, BG of some compositions have shown impressive ability to heal chronic skin wounds (Zhao et al, 2015; Naseri et al, 2017), mainly because of their antibacterial and proangiogenic properties (Broughton et al, 2006).…”

Section: Introductionmentioning

confidence: 99%

Toward Highly Dispersed Mesoporous Bioactive Glass Nanoparticles With High Cu Concentration Using Cu/Ascorbic Acid Complex as Precursor

et al. 2019

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Copper (Cu) ions have a variety of advantageous biological functionalities, such as proangiogenic and bactericidal activities. Given the intrinsic biodegradability and biocompatibility, silicate-based mesoporous bioactive glass nanoparticles (MBGNs) are considered as promising platforms for the delivery of Cu ions. However, effective incorporation of Cu into MBGNs still faces challenges, e.g., particle aggregation, the formation of insoluble crystalline Cu-based nanoparticles, and a low loading amount of Cu. We report a novel method to synthesize chemically homogenous and highly dispersed Cu-containing MBGNs (Cu-MBGNs) with tunable Cu concentration by using ascorbic acid/Cu complexes as the precursor of Cu in a microemulsion-assisted sol-gel approach. Cu-MBGNs exhibited a sphere-like shape with a particle size between 100 and 300 nm while their pore size varied from 2 to 10 nm. The inclusion of Cu, regardless of the incorporated concentration, did not significantly affect the morphology of particles. ICP-AES results indicated that the concentration of Cu in the particles could be conveniently tuned from 0 to ~6 mol% by controlling the amount of ascorbic acid/Cu complexes added, while the formation of crystalline Cu-based nanoparticles was avoided. The amorphous feature of Cu-MBGNs was proved by XRD, while the predominant oxidation state of Cu was evidenced to be Cu 2+ by XPS. The incorporation of Cu did not inhibit the apatite-forming ability (bioactivity) of the particles in contact with simulated body fluid. Cu-MBGNs exhibited the capability of releasing Cu, Si, and Ca ions over time in the physiological fluid. The concentration of released Cu ions could be controlled by selecting specific Cu-MBGNs of different Cu contents. The dissolution products of most Cu-MBGNs at the dosage of 1, 0.1, and 0.01 mg/mL did not exhibit cytotoxicity, while only 7Cu-MBGN was cytotoxic at the dosage of 1 mg/mL. This study provided a feasible strategy to synthesize highly dispersed amorphous Cu-MBGNs with high Cu concentrations for biomedical applications. The particles exhibit great potential as building blocks for developing composite 3D scaffolds, coatings, and drug carriers, particularly when a large amount of particles incorporated may compromise the properties of (polymer) matrix materials while a relatively high concentration of released Cu ions is still required.

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Section: Introductionmentioning

confidence: 99%

Toward Highly Dispersed Mesoporous Bioactive Glass Nanoparticles With High Cu Concentration Using Cu/Ascorbic Acid Complex as Precursor

et al. 2019

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“…Bioactive glasses (BGs) are currently used as implantable materials for the management of various types of bone disorders and diseases (Baino et al, 2018,a; Kargozar et al, 2019a; Miola et al, 2019). After five decades from the invention of Hench's 45S5 formulation, numerous commercially- produced BGs are being now used as effective substitute materials for hard tissue engineering.…”

Section: Introductionmentioning

confidence: 99%

Multiple and Promising Applications of Strontium (Sr)-Containing Bioactive Glasses in Bone Tissue Engineering

Kargozar

Montazerian

Fiume

et al. 2019

Front. Bioeng. Biotechnol.

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145

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Improving and accelerating bone repair still are partially unmet needs in bone regenerative therapies. In this regard, strontium (Sr)-containing bioactive glasses (BGs) are highly-promising materials to tackle this challenge. The positive impacts of Sr on the osteogenesis makes it routinely used in the form of strontium ranelate (SR) in the clinical setting, especially for patients suffering from osteoporosis. Therefore, a large number of silicate-, borate-, and phosphate-based BGs doped with Sr and produced in different shapes have been developed and characterized, in order to be used in the most advanced therapeutic strategies designed for the management of bone defects and injuries. Although the influence of Sr incorporation in the glass is debated regarding the obtained physicochemical and mechanical properties, the biological improvements have been found to be substantial both in vitro and in vivo . In the present study, we provide a comprehensive overview of Sr-containing glasses along with the current state of their clinical use. For this purpose, different types of Sr-doped BG systems are described, including composites, coatings and porous scaffolds, and their applications are discussed in the light of existing experimental data along with the significant challenges ahead.

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“… John et al (2017) developed a method for producing a 3D macroporous scaffold with controlled size and shape of pores decorated by HA and carbonate hydroxyapatite (CHA) and doped with spinel-like MgFe 2 O 4 magnetic nanoparticles for potential application in hyperthermal therapy that may also positively affect bone tissue regeneration. Another interesting approach to treat BM and tumors by hyperthermia is based on the utilization of a polymeric matrix embedding magnetic fillers ( Miola et al, 2019 ). In this regard, a composite bone cement obtained by incorporation of ferrimagnetic and bioactive glass-ceramic micro-particles in the PMMA polymeric matrix in different amounts has been proposed ( Bretcanu et al, 2006 ).…”

Section: Biomaterials For Bone Tissue Applicationsmentioning

confidence: 99%

Innovative Options for Bone Metastasis Treatment: An Extensive Analysis on Biomaterials-Based Strategies for Orthopedic Surgeons

Guerrieri

Montesi

Sprio

et al. 2020

Front. Bioeng. Biotechnol.

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Bone is the third most frequent site of metastasis, with a particular incidence in breast and prostate cancer patients. For example, almost 70% of breast cancer patients develop several bone metastases in the late stage of the disease. Bone metastases are a challenge for clinicians and a burden for patients because they frequently cause pain and can lead to fractures. Unfortunately, current therapeutic options are in most cases only palliative and, although not curative, surgery remains the gold standard for bone metastasis treatment. Surgical intervention mostly provides the replacement of the affected bone with a bioimplant, which can be made by materials of different origins and designed through several techniques that have evolved throughout the years simultaneously with clinical needs. Several scientists and clinicians have worked to develop biomaterials with potentially successful biological and mechanical features, however, only a few of them have actually reached the scope. In this review, we extensively analyze currently available biomaterials-based strategies focusing on the newest and most innovative ideas while aiming to highlight what should be considered both a reliable choice for orthopedic surgeons and a future definitive and curative option for bone metastasis and cancer patients.

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Glass-ceramics for cancer treatment: So close, or yet so far?

Cited by 105 publications

References 96 publications

Toward Highly Dispersed Mesoporous Bioactive Glass Nanoparticles With High Cu Concentration Using Cu/Ascorbic Acid Complex as Precursor

Toward Highly Dispersed Mesoporous Bioactive Glass Nanoparticles With High Cu Concentration Using Cu/Ascorbic Acid Complex as Precursor

Multiple and Promising Applications of Strontium (Sr)-Containing Bioactive Glasses in Bone Tissue Engineering

Innovative Options for Bone Metastasis Treatment: An Extensive Analysis on Biomaterials-Based Strategies for Orthopedic Surgeons

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