Glass ionomer cements with milled, dry chlorhexidine hexametaphosphate filler particles to provide long-term antimicrobial properties with recharge capacity

Bellis, Candice A.; Addison, Owen; Nobbs, Angela H.; Duckworth, Peter F.; Holder, James A; Barbour, Michele E

doi:10.1016/j.dental.2018.09.003

Cited by 13 publications

(13 citation statements)

References 30 publications

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“…Combining CHX in polymeric matrices have been attempted for sustained delivery specifically in polyalkenoate cements, commonly known as glass ionomer cements (GIC) that contain water soluble polymers such as poly (acrylic acid), poly (maleic) and poly(itaconic acid), which undergo an acid-base reaction to yield a cement. Although incorporation of CHX in GIC enables better protection against caries, it results in cements with inferior mechanical properties that exhibit a less than optimal period of sustained release [22,23]. Other derivatives of CHX such as CHX diacetate and chloride have also been incorporated in GICs; however, using CHX diacetate exhibits release over a few days, whilst a very rapid release occurs with CHX chloride.…”

Section: Chlorhexidinementioning

confidence: 99%

Antimicrobials in Dentistry

2021

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Dental caries (decay) is caused by pathogenic bacterial species, which afflicts nearly a third of the world′s population from early childhood to old age. Treatment of tooth decay often involves the use of filling materials to restore the cavity; however, if untreated, it can cause pain, infection and eventually lead to tooth loss. Since the oral environment is colonised by many different microorganisms, bacterial biofilms can form on these filling materials, contributing to secondary caries that can eventually lead to the failure of the dental restoration. Thus, preventing the formation of bacterial biofilms is an important strategy in the management of caries, which has led to research enabling antimicrobial capabilities in dental materials. Materials and pharmaceutical sciences are in a continuous race against microbial resistance but are trying to balance between beneficial biota associated with the oral cavity, and, of course, avoiding a harmful effect on tissues is challenging. This has, therefore, stemmed a substantial interest in both preventive and restorative measures that would enable limiting the formation of secondary caries, oral microbial biofilms, and the retention of tooth mineral. Thus, innovative strategies are being explored and here we present a review with a focus on strategies that can inhibit or limit the formation of bacterial biofilms.

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Section: Chlorhexidinementioning

confidence: 99%

Antimicrobials in Dentistry

2021

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“…Elemental analysis for C, H, N and P was carried out by the University of Bristol microanalytical laboratory. Other properties of the CHX-HMP have been reported in earlier publications [12][13][14] CHXdg alginate films were prepared as for CHX-HMP films by dissolving the alginate in CHXdg solution diluted to the required concentration, instead of the CHX-HMP suspension, and these are referred to as X-CHXdg where X again represents the concentration of CHX-HMP that provides the equivalent concentration of CHX in the material. Disk shaped specimens (ø = 10 mm) were cut from theses material and used for subsequent work.…”

Section: Synthesis and Analysis Of Chx-hmpmentioning

confidence: 99%

Alginate films augmented with chlorhexidine hexametaphosphate particles provide sustained antimicrobial properties for application in wound care

Duckworth

Maddocks

Rahatekar

et al. 2020

J Mater Sci: Mater Med

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All chronic wounds are colonised by bacteria; for some, colonisation progresses to become infection. Alginate wound dressings are used for highly exuding chronic wounds as they are very absorbent, taking up large quantities of exudate while maintaining a moist wound bed to support healing. Some alginate dressings are doped with antimicrobials, most commonly silver, but evidence regarding the efficacy of these is largely inconclusive. This manuscript describes the development and in vitro assessment of alginate materials doped with chlorhexidine hexametaphosphate (CHX-HMP), a sparingly soluble salt which when exposed to aqueous environments provides sustained release of the common antiseptic chlorhexidine. Comparator materials were a commercial silver alginate dressing material and an alginate doped with chlorhexidine digluconate (CHXdg). CHX-HMP alginates provided a dose-dependent CHX release which was sustained for over 14 days, whereas CHXdg alginates released limited CHX and this ceased within 24 h. CHX-HMP and silver alginates were efficacious against 5 major wound pathogens (MRSA, E. coli, P. aeruginosa, K. pneumoniae, A. baumannii) in a total viable count (TVC) and an agar diffusion zone of inhibition (ZOI) model. At baseline the silver alginate was more effective than the CHX-HMP alginate in the TVC assay but the CHX-HMP alginate was the more effective in the ZOI assay. After 7 days' artificial aging the CHX-HMP alginate was more effective than the silver alginate for four of the five bacteria tested in both assays. These materials may ultimately find application in the development of wound dressings for chronic wounds that provide sustained antimicrobial protection.

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“…casein phosphopeptide-amorphous calcium phosphate (CPP-ACP), chlorhexidine-hexametaphosphate nanoparticles (nCHX-HMP), chlorhexidine-bioactive glass, chitosan/ chlorhexidinecetrimide, chitosane-titanium dioxide nanoparticles CHT-nTiO 2 , chlorhexidine-encapsulated mesoporous silica nanoparticles, 12-methacryloyloxydodecylpyridinium bromide (MDPB)-nAg. [148][149][150][151][152][153][154][155][156][157][158][159][160][161][162][163] Cariostatic effect of GIC is still questionable, and it is also claimed that the low pH of GICs during setting reaction may contribute more than the fluoride leached to their antibacterial properties and that no antibacterial activity is exhibited after setting, [164][165][166][167] thus, the ability of GICs to ions exchange might lead to the hypothesis that GICs could potentially be used as carrier systems/delivery matrix for other active components, e.g. antimicrobial agents 168,169 in term of caries balancing, microbiome colonization inhibition.…”

Section: Organic Antimicrobials Syntheticmentioning

confidence: 99%

Untitled

2019

JABB

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The objective is to short review the current state of the art of dental antimicrobial agents in term of minimal invasive restorative dentistry. An outline of the most important aspects of dental antimicrobial agents was created, and a subsequent literature search for articles related was conducted. The current state of the art of antimicrobial agents includes a variety of species with broad ranges of properties. There is no agreement as to the choice of substances and concentration, however, there is a growing consensus regarding the need to use antimicrobial agents as additions into dental restorative materials' compound in patients with high intensity of active caries disease.

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Glass ionomer cements with milled, dry chlorhexidine hexametaphosphate filler particles to provide long-term antimicrobial properties with recharge capacity

Cited by 13 publications

References 30 publications

Antimicrobials in Dentistry

Antimicrobials in Dentistry

Alginate films augmented with chlorhexidine hexametaphosphate particles provide sustained antimicrobial properties for application in wound care

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