Glaucoma

Saccà, Sergio Claudio; Cartiglia, Cristina; Izzotti, Alberto

doi:10.1016/b978-0-12-401717-7.00004-6

Cited by 6 publications

(3 citation statements)

References 47 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The degeneration of these cells, which are actually neurons of the central nervous system (CNS) with axons in the optic nerve, causes progressive optical atrophy and irreversible visual loss [28]. In addition to ganglion cell loss, most glaucoma types are characterized by high intraocular pressure [29]. The diagnosis of open-angle glaucoma is often delayed due to the fact that its progression may be asymptomatic until a relatively late stage [30].…”

Section: Introductionmentioning

confidence: 99%

Health Benefits of Polyphenols and Carotenoids in Age-Related Eye Diseases

Bungău

Abdel-Daim

Ţiţ

et al. 2019

Oxidative Medicine and Cellular Longevity

182

100

View full text Add to dashboard Cite

Oxidative stress and inflammation play a critical role in the initiation and progression of age-related ocular abnormalities as cataract, glaucoma, diabetic retinopathy, and macular degeneration. Therefore, phytochemicals with proven antioxidant and anti-inflammatory activities, such as carotenoids and polyphenols, could be of benefit in these diseases. We searched PubMed and Web of Science databases for original studies investigating the benefits of different carotenoids and polyphenols in age-related ophthalmic diseases. Our results showed that several polyphenols (such as anthocyanins, Ginkgo biloba, quercetin, and resveratrol) and carotenoids (such as lutein, zeaxanthin, and mezoxanthin) have shown significant preventive and therapeutic benefits against the aforementioned conditions. The involved mechanisms in these findings include mitigating the production of reactive oxygen species, inhibiting the tumor necrosis factor-α and vascular endothelial growth factor pathways, suppressing p53-dependent apoptosis, and suppressing the production of inflammatory markers, such as interleukin- (IL-) 8, IL-6, IL-1a, and endothelial leucocyte adhesion molecule-1. Consumption of products containing these phytochemicals may be protective against these diseases; however, adequate human data are lacking. This review discusses the role and mechanisms of polyphenols and carotenoids and their possible synergistic effects on the prevention and treatment of age-related eye diseases that are induced or augmented by oxidative stress and inflammation.

show abstract

Section: Introductionmentioning

confidence: 99%

Health Benefits of Polyphenols and Carotenoids in Age-Related Eye Diseases

Bungău

Abdel-Daim

Ţiţ

et al. 2019

Oxidative Medicine and Cellular Longevity

182

100

View full text Add to dashboard Cite

show abstract

“…Oxidative stress is an important risk factor in the pathogenesis of primary open-angle glaucoma (POAG), with oxidative stress markers elevated in POAG patients. [93] Similarly, oxidative DNA damage after hydrogen peroxide treatment is greater in POAG patients than in healthy controls, and antioxidant enzyme levels lower. [94] The E50K OPTN mutation causes familial POAG and disables OPTN oligomerisation.…”

Section: F I G U R Ementioning

confidence: 99%

The evolution of selective autophagy as a mechanism of oxidative stress response

Ratliffe,

Kataura,

Otten

et al. 2023

BioEssays

View full text Add to dashboard Cite

Ageing is associated with a decline in autophagy and elevated reactive oxygen species (ROS), which can breach the capacity of antioxidant systems. Resulting oxidative stress can cause further cellular damage, including DNA breaks and protein misfolding. This poses a challenge for longevous organisms, including humans. In this review, we hypothesise that in the course of human evolution selective autophagy receptors (SARs) acquired the ability to sense and respond to localised oxidative stress. We posit that in the vicinity of protein aggregates and dysfunctional mitochondria oxidation of key cysteine residues in SARs induces their oligomerisation which initiates autophagy. The degradation of damaged cellular components thus could reduce ROS production and restore redox homeostasis. This evolutionarily acquired function of SARs may represent one of the biological adaptations that contributed to longer lifespan. Inversely, loss of this mechanism can lead to age‐related diseases associated with impaired autophagy and oxidative stress.

show abstract

“…[5][6][7][8] Glaucoma is typically induced by the abnormal accumulation of aqueous humour (AH), a biofluid in the eye, which leads to elevation of the intraocular pressure (IOP), exerts physical stress, and ultimately damages the optic nerve head. So far the most practiced therapeutic scheme of glaucoma is to manage IOP and reduce it to a normal range between 11 and 21 mmHg in most cases or to single-digit mmHg for end-stage glaucoma patients, 2,9,10 either by reducing the production of the AH or increasing its drainage. Further evidence suggests that an IOP of 8-12 mmHg may even be required in advanced glaucoma.…”

Section: Introductionmentioning

confidence: 99%