Glaucoma and CNS. Comparison of fMRI results in high tension and normal tension glaucoma

Lešták, Jan; Tintěra, Jaroslav; Svata, Zuzana; Ettler, Lukas; Rozsíval, P

doi:10.5507/bp.2013.038

Cited by 16 publications

(18 citation statements)

References 38 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Few fMRI studies have been conducted on glaucoma patients. [ 21 – 23 , 32 – 34 ] The first such work, comparing VF defects with fMRI responses, included seven patients with various forms of optic neuropathy, including glaucoma. It was found that stimulation of the affected eye did not activate the primary visual cortex in the region corresponding to the VF defect [ 34 ].…”

Section: Discussionmentioning

confidence: 99%

Evaluation of Glaucomatous Damage via Functional Magnetic Resonance Imaging, and Correlations Thereof with Anatomical and Psychophysical Ocular Findings

et al. 2015

View full text Add to dashboard Cite

PurposeTo evaluate the functional magnetic resonance imaging (fMRI) response to binocular visual stimulation and the association thereof with structural ocular findings and psychophysical test results in patients with glaucoma, and controls.MethodsCross-sectional study. Participants underwent a complete ophthalmic examination, including Humphrey 24-2 visual field (VF) testing and optical coherence tomography. Binocular VF in each quadrant was determined using an integrated method. Patients with glaucoma were assigned to three subgroups: initial, asymmetrical and severe glaucoma. Regions of interest (ROIs) were determined anatomically. fMRI (3 T) was performed using a bilaterally presented polar angle stimulus, and the accompanying changes in blood oxygen level-dependent (BOLD) signals were obtained from the occipital poles and calcarine ROIs. We used generalized estimation equation models to compare anatomical and functional data between the groups.ResultsA total of 25 subjects were enrolled, of whom 17 had glaucoma and 8 were controls. Significant associations between quadrant binocular VF sensitivities and fMRI responses were found in the occipital pole ROIs (p = 0.033) and the calcarine ROIs (p = 0.045). In glaucoma severity subgroup analysis, retinal nerve fiber layer (RNFL) thickness was associated with the BOLD response of the calcarine and occipital pole ROIs (p = 0.002 and 0.026, respectively). The initial and asymmetrical glaucoma subgroups had similar binocular VF sensitivities and RNFL thicknesses, but distinct BOLD responses.ConclusionsThe response of the visual cortex to binocular stimulation was associated with binocular VF sensitivity. RNFL thickness was associated with the BOLD response of the calcarine and occipital pole ROIs.

show abstract

Section: Discussionmentioning

confidence: 99%

Evaluation of Glaucomatous Damage via Functional Magnetic Resonance Imaging, and Correlations Thereof with Anatomical and Psychophysical Ocular Findings

et al. 2015

View full text Add to dashboard Cite

show abstract

“…Functional activity resulted greatly reduced within primary visual cortex after visual input from the glaucomatous eye in all studies using fMRI both in POAG (Duncan et al, 2007a ; Qing et al, 2010 ; El-Rafei et al, 2013 ; Lestak et al, 2014 ; Borges et al, 2015 ; Gerente et al, 2015 ; Murphy et al, 2016 ; Zhang et al, 2016 ; Jiang et al, 2017 ; Zhou et al, 2017b ), NTG (El-Rafei et al, 2013 ; Lestak et al, 2014 ; Zhang et al, 2016 ) and PACG patients (Song et al, 2012 ).…”

Section: Resultsmentioning

confidence: 94%

Changes of Visual Pathway and Brain Connectivity in Glaucoma: A Systematic Review

2018

View full text Add to dashboard Cite

Background: Glaucoma is a leading cause of irreversible blindness worldwide. The increasing interest in the involvement of the cortical visual pathway in glaucomatous patients is due to the implications in recent therapies, such as neuroprotection and neuroregeneration.Objective: In this review, we outline the current understanding of brain structural, functional, and metabolic changes detected with the modern techniques of neuroimaging in glaucomatous subjects.Methods: We screened MEDLINE, EMBASE, CINAHL, CENTRAL, LILACS, Trip Database, and NICE for original contributions published until 31 October 2017. Studies with at least six patients affected by any type of glaucoma were considered. We included studies using the following neuroimaging techniques: functional Magnetic Resonance Imaging (fMRI), resting-state fMRI (rs-fMRI), magnetic resonance spectroscopy (MRS), voxel- based Morphometry (VBM), surface-based Morphometry (SBM), diffusion tensor MRI (DTI).Results: Over a total of 1,901 studies, 56 case series with a total of 2,381 patients were included. Evidence of neurodegenerative process in glaucomatous patients was found both within and beyond the visual system. Structural alterations in visual cortex (mainly reduced cortex thickness and volume) have been demonstrated with SBM and VBM; these changes were not limited to primary visual cortex but also involved association visual areas. Other brain regions, associated with visual function, demonstrated a certain grade of increased or decreased gray matter volume. Functional and metabolic abnormalities resulted within primary visual cortex in all studies with fMRI and MRS. Studies with rs-fMRI found disrupted connectivity between the primary and higher visual cortex and between visual cortex and associative visual areas in the task-free state of glaucomatous patients.Conclusions: This review contributes to the better understanding of brain abnormalities in glaucoma. It may stimulate further speculation about brain plasticity at a later age and therapeutic strategies, such as the prevention of cortical degeneration in patients with glaucoma. Structural, functional, and metabolic neuroimaging methods provided evidence of changes throughout the visual pathway in glaucomatous patients. Other brain areas, not directly involved in the processing of visual information, also showed alterations.

show abstract

“…The frontal lobe also transmits visual information to the oculomotor complex [16] . Some prior studies had similar results, although none of these studies analyzed different types of primary glaucoma simultaneously [25,26] . Moreover, in our study, when we used BA18 and BA19 (related to superior visual cortex) as the seeds, we found that the connection between the frontal lobe and the occipital lobe significantly increased in all three groups of visual field-defected glaucoma patients, which indicated that the frontal lobe may have a special relationship with the visual pathway.…”

Section: Brain Region Of Functional Connectivitymentioning

confidence: 97%

Similarities and Differences in the Central Nervous System between Different Types of Primary Glaucoma by Multimodal MRI

Yao¹,

Liu²,

Pan³

et al. 2019

Preprint

View full text Add to dashboard Cite

Background. To investigate the similarities and differences in the structure and function of the central nerve system (CNS) among normal tension glaucoma (NTG), primary open-angle glaucoma with high intraocular pressure (HTG) and primary angle-closure glaucoma (PACG) patients. Methods. Ophthalmic examinations and multimodal magnetic resonance imaging (MRI) were performed. The results of brain functional connectivity (FC) were obtained based on the resting state MRI (rs-fMRI). Voxel-based morphometry (VBM) was applied to analyze structural images to obtain the volume change in the gray matter on 3D T1-weighted imaging (T1WI). Results. We found that frontal lobe FC increased in all three groups. Temporal lobe FC increased in the NTG group, while the FC of the cingulate gyrus and postcentral gyrus increased in the HTG and PACG groups by rs-fMRI. There were no gray matter volume changes in the NTG, while the gray matter of the frontal gyrus changed in the HTG and PACG. Moreover, the gray matter of the precentral gyrus changed in PACG, and the parietal lobe and supra marginal lobe changed in the HTG. The white matter of the inferior parietal lobe and postcentral gyrus increased, while that in the inferior temporal lobe decreased in the NTG group. The white matter in the HTG and PACG groups showed significant alterations in the medial occipital gyrus. Conclusions. The NTG group had different manifestations compared with the HTG and PACG groups regarding changes in brain structure and function, suggesting that pathogenic processes might differ between patients with normal-tension and high-tension POAG.

show abstract

Glaucoma and CNS. Comparison of fMRI results in high tension and normal tension glaucoma

Cited by 16 publications

References 38 publications

Evaluation of Glaucomatous Damage via Functional Magnetic Resonance Imaging, and Correlations Thereof with Anatomical and Psychophysical Ocular Findings

Evaluation of Glaucomatous Damage via Functional Magnetic Resonance Imaging, and Correlations Thereof with Anatomical and Psychophysical Ocular Findings

Changes of Visual Pathway and Brain Connectivity in Glaucoma: A Systematic Review

Similarities and Differences in the Central Nervous System between Different Types of Primary Glaucoma by Multimodal MRI

Contact Info

Product

Resources

About