Glaucoma and mortality in the Beijing Eye Study

Xu, Liang; Wang, Y X; Jonas, Jost B.

doi:10.1038/sj.eye.6703072

Cited by 19 publications

(19 citation statements)

References 26 publications

(26 reference statements)

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“…Unlike Beijing Eye Study, we did not find an association between PAC and PACG with mortality 17. This could be attributed to factors specific to the population or study design or the confounders adjusted in analysis as described above.…”

Section: Discussioncontrasting

confidence: 77%

“…Most of these studies were undertaken in Caucasian populations and most focused on POAG—only one study investigated a black population 16. In the only study from Asia, there was a strong association between mortality and PACG but not with POAG 17. Reports on the association of mortality with raised intraocular pressure (IOP) and pseudoexfoliation (PXF) are also inconsistent with some showing an association10 16 whereas others have not 12 18–20.…”

Section: Introductionmentioning

confidence: 99%

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Glaucoma-associated long-term mortality in a rural cohort from India: the Andhra Pradesh Eye Disease Study

et al. 2018

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AimTo evaluate glaucoma-associated mortality in a rural cohort in India.MethodsThe study cohort comprised individuals aged 40 years and above who took part in the Andhra Pradesh Eye Disease Study (APEDS1) during 1996–2000. All participants underwent detailed comprehensive eye examination. Glaucoma was defined using International Society of Geographic and Epidemiologic Ophthalmology criteria. This cohort was followed up after a decade (June 2009 to January 2010; APEDS2). Mortality HR analysis for ocular risk factors was performed using Cox proportional hazards regression after adjusting for sociodemographic, lifestyle and clinical variables.ResultsIn APEDS1, 2790 individuals aged more than or equal to 40 years were examined. 47.4% were male. Forty-five participants had primary open angle glaucoma (POAG) and 66 had primary angle closure disease (PACD). Ten years later, 1879 (67.3%) were available, 739 (26.5%) had died and 172 (6.2%) had migrated; whereas 22 of the 45 (48.8%) with POAG and 22 of the 66 (33.3%) with PACD had died. In univariate analysis, a higher mortality was associated with POAG (HR 1.9; 95% CI 1.23 to 2.94), pseudoexfoliation (HR 2.79; 95% CI 2.0 to 3.89), myopia (HR 1.78; 95% CI 1.54 to 2.06) and unit increase in cup:disc ratio (HR 4.49; 95% CI 2.64 to 7.64). In multivariable analysis, only cup:disc ratio remained independently associated with mortality (HR 2.5; 95% CI 1.3 to 5.1). The association remained significant when other ocular parameters were included in the model (HR 2.1; 95% CI 1.03 to 4.2).ConclusionsThis is the first longitudinal study to assess the association of glaucoma and mortality in a rural longitudinal cohort in India. Increased cup:disc ratio could be a potential marker for ageing and would need further validation.

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Section: Discussioncontrasting

confidence: 77%

Section: Introductionmentioning

confidence: 99%

Glaucoma-associated long-term mortality in a rural cohort from India: the Andhra Pradesh Eye Disease Study

et al. 2018

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“…High myopia defined as a myopic refractive error > − 8 D was present in 1.5% (95% CI 1.1–1.9) of the subjects. It was significantly (p < 0.001) associated with lower BCVA, larger optic disc size, larger size of beta zone and alpha zone of peripapillary atrophy, and a lower macular drusen count (p = 0.02) (Xu et al. 2007a).…”

Section: Resultsmentioning

confidence: 99%

“…Of the 4439 subjects who participated in the survey in 2001, 3251 (73.2%) returned for follow-up examination; 143 (3.2%) subjects had died and 1045 (23.5%) subjects did not agree to be re-examined or had moved away (Xu et al 2008g). The mortality rate was significantly (p < 0.001; OR = 4.72, 95% CI 2.67, 8.33) higher in the glaucoma subjects (11.1 ± 2.7% [95% CI 5.8, 16.4]) than in the participants without glaucoma (2.6 ± 0.2% [95% CI 2.2, 3.0]).…”

Section: Glaucoma and Mortalitymentioning

confidence: 99%

The Beijing Eye Study

Jonas

Wang

2009

Acta Ophthalmologica

109

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ABSTRACT.Purpose: This review presents and summarizes the findings of the Beijing Eye Study. Methods: The Beijing Eye Study is a population-based study which included 4439 of 5324 subjects (aged ‡ 40 years) who were initially examined in 2001. The study was repeated in 2006, when 3251 (73.2% of 4439, or 61.1% of 5324) of the original subjects participated. Participants underwent a series of examinations including: refractometry; pneumotonometry; biomicroscopy assisted by slit-lamp; optical coherence tomography of the anterior segment; photography of the cornea, lens, optic disc, macula and fundus; blood sampling for laboratory tests; blood pressure measurements, and determinations of anthropomorphic parameters. They were also asked to complete a questionnaire which included questions on socioeconomic parameters, and awareness and treatment of ocular and general diseases. Results: We present normative data for refractive error, anterior segment measurements, intraocular pressure and optic disc structures and their associations, frequency and causes of visual impairment, blindness and visual field defects, prevalences of trachoma, pterygia, open-angle glaucoma and angle-closure glaucoma, cortical, nuclear and posterior subcapsular cataract, age-related macular degeneration, retinal vein occlusions, diabetes mellitus and diabetic retinopathy, myelinated nerve fibres, and retinitis pigmentosa, and associated and risk factors. Discussion: These data may be helpful for dealing with public health issues in China and for assessing associated and risk factors of ocular and general diseases in general.

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“…The associations between body height and ocular parameters may have an additional clinical meaning. A recent study suggested that subjects with angle-closure glaucoma have a higher mortality than subjects with open-angle glaucoma or non-glaucomatous subjects [20]. The reason for the higher mortality of subjects with angle-closure glaucoma may have been that these subjects had a smaller body stature due to the association between anterior chamber depth and body height.…”

Section: Discussionmentioning

confidence: 97%