Glaucoma and obstructive sleep apnoea syndrome

Faridi, Omar S.; Park, Sung Chul; Liebmann, Jeffrey M.; Ritch, Robert

doi:10.1111/j.1442-9071.2012.02768.x

Cited by 67 publications

(67 citation statements)

References 107 publications

(264 reference statements)

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“…18 In patients with OSA, blood flow to the ONH may be altered and may result in glaucoma. 9 The ophthalmic artery is a branch of the internal carotid artery and shows similar characteristics regarding autoregulation of blood flow. In patients with OSA, the cerebral blood flow in response to hypoxia returns to normal levels after treatment with CPAP for a period of 6 weeks.…”

Section: Discussionmentioning

confidence: 99%

“…5 Previous studies have shown an association between OSA and glaucoma in general and NTG in particular. [6][7][8][9][10][11][12][13] This study was conducted to investigate the prevalence and progression of glaucoma in patients receiving treatment for OSA. We also investigated whether there is an association between the severity of OSA and the incidence of glaucoma.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Prevalence of glaucoma in patients with moderate to severe obstructive sleep apnea: ocular morbidity and outcomes in a 3 year follow-up study

Hashim

Mansouri

Farouk

et al. 2014

Eye

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Purpose This study was conducted to investigate the prevalence and progression of glaucoma in patients receiving treatment for obstructive sleep apnea (OSA). We also investigated whether there is an association between severity of OSA and the incidence of glaucoma. Methods A total of 39 patients aged 430 years who had been diagnosed with moderate and severe OSA in the sleep clinic at Hamad General Hospital were assessed for the presence of glaucoma. The severity of OSA was graded as mild, moderate, or severe based on American Association of Sleep Medicine (AASM) criteria using the apnea hypopnea index. Before enrollment, all patients underwent a complete ophthalmic examination including serial visual field tests, optical coherence tomography (OCT) with fundus photographs, and pachymetry. Enrolled patients were followed up in the ophthalmology outpatient clinic and sleep clinic for a period of 3 years. Results Examinations found that 8 (20.5%; 95% confidence interval (CI) 9.9-37%) of the 39 patients with OSA had glaucoma. Six (75%; 95% CI 36-96%) of these patients had normal-tension glaucoma (NTG) and two (25%; 95% CI 4.5-64.4%) patients had hightension glaucoma. Among the 27 patients with severe OSA, 7 (25.9%; 95% CI 8-34%) had glaucoma, and among 12 patients with moderate OSA, 1 (8.3%; 95% CI 0.1-15%) had glaucoma. During the course of follow-up, two patients who previously did not have glaucoma were reclassified as NTG and two patients with glaucoma deteriorated. A higher prevalence of glaucoma in the severe OSA group compared with the moderate OSA group was found, albeit a statistically significant difference could not be attained (P ¼ 0.4). Conclusions Our study showed that severe OSA is an important risk factor for developing glaucoma. Adequate treatment of OSA, along with optimal ophthalmic care, resulted in better control of glaucoma.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Prevalence of glaucoma in patients with moderate to severe obstructive sleep apnea: ocular morbidity and outcomes in a 3 year follow-up study

Hashim

Mansouri

Farouk

et al. 2014

Eye

View full text Add to dashboard Cite

show abstract

“…Attention should be paid to various IOP-independent factors potentially linking OSAS and glaucoma, including ocular perfusion pressure, autonomic dysfunction, ischemia, inflammation, oxidative stress, mitochondrial dysfunction, and hypercapnia, all of which stem from episodic hypoxia during nocturnal sleep in OSAS patients. 45 Future and further studies are required to better understand the mechanism of OSASassociated glaucoma leading to retinal ganglion cell death without IOP elevation.…”

Section: Discussionmentioning

confidence: 99%

Continuous Intraocular Pressure Monitoring During Nocturnal Sleep in Patients With Obstructive Sleep Apnea Syndrome

Shinmei

Nitta²,

Saitô

et al. 2016

Invest. Ophthalmol. Vis. Sci.

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“…4 IOPs have a critical role in the development and/or progression of glaucoma. 15 Mojon et al 8 found a positive correlation between the respiratory disturbance index and IOP. Purvin et al 9 also demonstrated that intracranial pressure increases as a result of episodic hypoxemia and hypercapnia, thereby leading to papilledema and an increased risk of eye disease.…”

Section: Discussionmentioning

confidence: 99%

Increased risk of open-angle glaucoma following chronic rhinosinusitis: a population-based matched-cohort study

Chung

Lin

et al. 2013

Eye

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Purpose Anatomically, the eyes and paranasal sinuses are neighboring structures and some studies have mentioned eye disease in conjunction with chronic rhinosinusitis (CRS). However, to the best of our knowledge, no prior research has investigated the risk of developing openangle glaucoma (OAG) among CRS patients. This study aims to provide an estimated risk of developing OAG among patients with CRS by using a population-based data set in Taiwan. Methods This retrospective cohort study used data sourced from the 'Longitudinal Health Insurance Database 2000'. A total of 15 642 CRS patients were included in the study cohort and 46 926 subjects were randomly extracted as a comparison cohort. A cox proportional-hazards regression analysis was performed to calculate the 5-year risk of subsequently developing OAG following a diagnosis of CRS between the study cohort and the comparison cohort. Results The incidence rate of developing OAG over the 5-year follow-up period was 5.45 (95% CI: 4.95-5.98) per 1000 person-years for the study cohort and 2.80 (95% CI: 2.60-3.03) per 1000 person-years for the comparison cohort. After censoring the cases that died over the 5-year period and adjusting for the factors of monthly income, geographic region, hypertension, diabetes, coronary heart disease, hyperlipidemia, and hypothyroidism the hazard ratio for developing OAG over the 5-year period for subjects with CRS to subjects without CRS was 1.73 (95% CI: 1.53-1.96). Conclusion We found that those subjects with CRS had a significantly higher risk of developing OAG over the 5-year follow-up period as compared with subjects without CRS.

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Glaucoma and obstructive sleep apnoea syndrome

Cited by 67 publications

References 107 publications

Prevalence of glaucoma in patients with moderate to severe obstructive sleep apnea: ocular morbidity and outcomes in a 3 year follow-up study

Prevalence of glaucoma in patients with moderate to severe obstructive sleep apnea: ocular morbidity and outcomes in a 3 year follow-up study

Continuous Intraocular Pressure Monitoring During Nocturnal Sleep in Patients With Obstructive Sleep Apnea Syndrome

Increased risk of open-angle glaucoma following chronic rhinosinusitis: a population-based matched-cohort study

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