Glaucoma and ocular blood flow: an anatomical perspective

Siesky, Brent; Harris, Alon; Amireskandari, Annahita; Marek, Brian

doi:10.1586/eop.12.41

Cited by 10 publications

(12 citation statements)

References 122 publications

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“…Abnormal ocular blood flow may play a crucial role in patients with normal-tension glaucoma [8]. Reduction in ocular perfusion pressure and ocular blood flow is also a risk factor in glaucoma patients [6]. Acupuncture improved the retrobulbar circulation and IOP of patients with open-angle glaucoma in a study using color Doppler imaging [14].…”

Section: Sg Ag Egmentioning

confidence: 99%

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Effect of Acupuncture on Intraocular Pressure in Glaucoma Patients: A Single‐Blinded, Randomized, Controlled Trial

Chen

Yieh²,

Liao

et al. 2020

Evidence-Based Complementary and Alternative Medicine

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Glaucoma is characterized by the degeneration of retinal ganglion cells that cause progressive optic neuropathy, finally resulting in changes to the optic nerve head. Lowering intraocular pressure (IOP) is the only method proven for treating glaucoma. Several studies have discovered that acupuncture can reduce IOP and also increase ocular perfusion and ocular blood flow. Therefore, the present study investigated the effect of acupuncture on IOP in glaucoma patients. We conducted a single-blinded, randomized, controlled trial involving 45 glaucoma patients. The results indicated that the difference between the IOP 60 min after the intervention and IOP immediately before the intervention was greater in the acupuncture group (AG) and electroacupuncture group (EG) than in the sham group (SG) for all four of the interventions performed and in both eyes (all p<0.05). The IOP difference between immediately before the first intervention and after finishing the final intervention was also greater in the AG and EG than in the SG in both eyes (all p<0.05). In conclusion, IOP was reduced at 60 min after acupuncture or electroacupuncture was performed at BL1 and EX-HN7. Additionally, IOP was reduced after finishing four acupuncture or electroacupuncture sessions. Therefore, our results suggest that acupuncture and electroacupuncture are beneficial for lowering IOP in glaucoma patients. This trial is registered with NCT04157530.

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Section: Sg Ag Egmentioning

confidence: 99%

“…Both old age and high intraocular pressure (IOP) are risk factors for glaucoma development [5]. Decreased ocular perfusion and ocular blood flow may also play roles in the development of openangle glaucoma [6,7]. Furthermore, impairment of ocular vascular autoregulation has been reported in patients with normal-tension glaucoma [8].…”

Section: Introductionmentioning

confidence: 99%

Effect of Acupuncture on Intraocular Pressure in Glaucoma Patients: A Single‐Blinded, Randomized, Controlled Trial

Chen

Yieh²,

Liao

et al. 2020

Evidence-Based Complementary and Alternative Medicine

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show abstract

“…С появлением ОКТ-ангиографии в качестве критериев ранней диагностики стали рассматривать показатели кровотока сосудов сетчатки и хориоидеи в перипапиллярной и макулярной зонах [11]. Показано, что уже на ранних стадиях глаукомного процесса наблюдается наиболее выраженное снижение плотности капилляров в нижних отделах перипапиллярной сетчатки и макулы, а также на уровне решетчатой мембраны склеры, предшествующее структурным (изменения в ДЗН) и функциональным (поле зрения) нарушениям [12][13][14][15][16][17][18].…”

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“…Основной причиной сосудистой дисрегуляции считается вазоспазм, приводящий к дефициту кровообращения в ДЗН, гипоксии и ишемии, увеличению чувствительности ганглиозных клеток сетчатки (ГКС), к росту ВГД и, как следствие, апоптозу ганглиозных клеток [28]. Благодаря ауторегуляции глазного кровотока при начальной глаукоме в отдельных участках перипапиллярной сетчатки кровоток может быть даже усилен, однако по мере развития процесса он снижается [11].…”

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Personalized medicine in glaucoma management

Журавлева

Киселева

Кириллова

2019

Rossijskij oftalʹmologičeskij žurnal

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The review addresses the management of primary glaucoma as a socially significant multifactorial disease. The main reasons that impede the timely diagnosis and treatment of patients with glaucoma are indicated: blurring of boundaries, conventionality of standards, and lack of individualized approach to treatment. The main risk factors for the development of glaucoma are highlighted, with special attention to hereditary predisposition and the role of “medicine of the future” in managing glaucoma. Four fundamental principles are described: personalization, prediction, prevention and participative attitude (P4 medicine). Advanced scientific understanding of the key risk factors for the development and progression of glaucoma, together with a modern personalized and personified approach will further develop precise individual strategies for the prevention and treatment of the disease.

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“…The global burden of visual impairment due to glaucoma is projected to escalate by the year 2040, with almost 111.8 million of the world population affected by this second leading cause of blindness and 11.1 million of these are estimated to be bilaterally blind9101112 Likewise, up to 82 in 100 000 individuals are estimated to suffer from the most common type of AION, non-arteritic anterior ischemic optic neuropathy (NAION) annually1314. Over the years, mounting evidence has associated these debilitating ocular diseases with hemodynamic alterations in the ONH151617 Although elevated intraocular pressure (IOP) has been identified as the primary disease factor for glaucoma, its pathogenesis still remains a topic of much challenge in ophthalmic research owing to myriad other risk factors that may eventually cause optic nerve and retinal dysfunctions, regardless of the IOP51819. It has been suggested that treatment options which increase ONH perfusion may facilitate clinical management of GON more effectively20.…”

mentioning

confidence: 99%

First insight into the proteome landscape of the porcine short posterior ciliary arteries: Key signalling pathways maintaining physiologic functions

Manicam

Perumal

Pfeiffer

et al. 2016

Sci Rep

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Short posterior ciliary arteries (sPCA) provide the major blood supply to the optic nerve head. Emerging evidence has linked structural and functional anomalies of sPCA to the pathogenesis of several ocular disorders that cause varying degrees of visual loss, particularly anterior ischaemic optic neuropathy and glaucoma. Although the functional relevance of this vascular bed is well-recognized, the proteome of sPCA remains uncharacterized. Since the porcine ocular system closely resembles that of the human’s and is increasingly employed in translational ophthalmic research, this study characterized the proteome of porcine sPCA employing the mass spectrometry-based proteomics strategy. A total of 1742 proteins and 10527 peptides were identified in the porcine sPCA. The major biological processes involved in the maintenance of physiological functions of the sPCA included redox and metabolic processes, and cytoskeleton organization. These proteins were further clustered into diverse signalling pathways that regulate vasoactivity of sPCA, namely the tight junction, α- and β-adrenoceptor, 14-3-3, nitric oxide synthase and endothelin-1 -mediated signalling pathways. This study provides the first insight into the complex mechanisms dictating the vast protein repertoire in normal vascular physiology of the porcine sPCA. It is envisioned that our findings will serve as important benchmarks for future studies of sPCA.

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Glaucoma and ocular blood flow: an anatomical perspective

Cited by 10 publications

References 122 publications

Effect of Acupuncture on Intraocular Pressure in Glaucoma Patients: A Single‐Blinded, Randomized, Controlled Trial

Effect of Acupuncture on Intraocular Pressure in Glaucoma Patients: A Single‐Blinded, Randomized, Controlled Trial

Personalized medicine in glaucoma management

First insight into the proteome landscape of the porcine short posterior ciliary arteries: Key signalling pathways maintaining physiologic functions

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