Glaucoma Detection using the GDx Nerve Fiber Analyzer and the Retinal Thickness Analyzer (RTA)

Bowd, Christopher; Klein, Nigel; Stemberger, K; Grus, Franz H.; Pfeiffer, Norbert

doi:10.1177/112067210601600210

Cited by 3 publications

(1 citation statement)

References 27 publications

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“…Weiterhin konnte gezeigt werden, dass diese "Autoantikörper-Muster" konsistent sind zwischen verschiedenen Studienpopulationen. So verglichen wir in einer Studie eine Patientenpopulation in Mainz mit einer Kohorte in St. Louis (USA) und konnten hier extrem große Übereinstimmungen in der Veränderung der Antikörperprofile nachweisen [27] (• ▶ Abb. 2).…”

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Zusammenhang zwischen oxidativem Stress und immunologischen Störungen beim Glaukom

Grus¹

2010

Klin Monatsbl Augenheilkd

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Elevated intraocular pressure does not explain glaucoma in all patients, but there is information that autoimmune mechanisms may be involved in this disorder. We have demonstrated in several studies that glaucoma patients reveal changes in their immune reactivities against ocular antigens. The mechanisms of these reactivities are still widely unknown, but oxidative pathways could play a major role. There is evidence that free radicals are able to alter the ability of glial cells to be recognized as antigens. Furthermore, one can assume that during the aging process posttranslational changes, e. g., oxidation of ocular antigens increase with age. It is feasible that these changed antigens may trigger such changes. in an autoimmune glaucoma animal model we have shown that immunological processes after immunisation can lead to a loss of retinal ganglion cells. Considering that these changes in natural autoimmunity can be found consistently amongst different study populations, it might be a promising new tool for glaucoma diagnosis and new therapeutic immunomodulating options.

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Zusammenhang zwischen oxidativem Stress und immunologischen Störungen beim Glaukom

Grus¹

2010

Klin Monatsbl Augenheilkd

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Gesundheitsökonomische Aspekte des Glaukomscreenings

Hirneiß¹,

Niedermaier

Kernt³

et al. 2009

Ophthalmologe

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Adjusted color probability codes for peripapillary retinal nerve fiber layer thickness in healthy Koreans

et al. 2014

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BackgroundThough a newly developed spectral domain optical coherence tomography (OCT) is at the center of interests for many ophthalmologic researchers and clinicians, its own characteristics are not fully evaluated yet. The main purpose of this study was to establish the adjusted color probability codes for peripapillary retinal nerve fiber layer (RNFL) thickness in healthy Koreans and to compare them with original color codes provided by spectral domain OCT.MethodsTwo hundred ninety-five healthy Korean eyes were enrolled and their peripapillary RNFL thickness was measured by Cirrus OCT. For each decade of age, the normal thickness reference was determined on the basis of z-scores and the adjusted color probability codes were established. Then the agreements between adjusted and original color codes were calculated using weighted Kappa (Kw) coefficient.ResultsOn the basis of Kw coefficient, the overall agreement between the adjusted and original probability color codes was not excellent (Kw range of 0.500 to 0.806). If the adjusted probability codes were assumed as a standard of comparison, the original color codes showed the false-negative in 11% of eyes and the false-positive in 0.3% of eyes for average RNFL thickness.ConclusionsAdjusted color probability codes judged by the Korean normative data showed a discrepancy with original codes. It implies that normal reference and adjusted probability codes for each ethnicity might be needed to determine whether a certain RNFL thickness is within normal range or not.

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Glaucoma Detection using the GDx Nerve Fiber Analyzer and the Retinal Thickness Analyzer (RTA)

Abstract: GDx showed better discrimination and better sensitivities at fixed specificities than RTA. The currently available RTA optic disk analysis software likely cannot replace GDx RNFL analysis software for successful glaucoma diagnosis.

Cited by 3 publications

References 27 publications

Zusammenhang zwischen oxidativem Stress und immunologischen Störungen beim Glaukom

Zusammenhang zwischen oxidativem Stress und immunologischen Störungen beim Glaukom

Gesundheitsökonomische Aspekte des Glaukomscreenings

Adjusted color probability codes for peripapillary retinal nerve fiber layer thickness in healthy Koreans

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