Glaucoma following cataract surgery in the first 2 years of life: frequency, risk factors and outcomes from IoLunder2

Solebo, Ameenat Lola; Rahi, Jugnoo S

doi:10.1136/bjophthalmol-2019-314804

Cited by 26 publications

(94 citation statements)

References 27 publications

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“…Treatment Study Registry (TAPS) and the IoLunder2 cohort, demonstrating that GRAE is a common complication threatening visual prognosis after cataract surgery in infants and young children, 3,[23][24][25] with incidence increasing gradually over the postoperative interval. The Infant Aphakia Treatment Study (IATS) reported that the incidence of GRAE in children aged one to six months at the time of cataract extraction rose from 12% at 1 year to 40% at 10 years after surgery.…”

Section: Discussionmentioning

confidence: 99%

In-the-Bag Versus Ciliary Sulcus Secondary Intraocular Lens Implantation for Pediatric Aphakia: A Prospective Comparative Study

Liu

Jin

Tan

et al. 2022

American Journal of Ophthalmology

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Section: Discussionmentioning

confidence: 99%

In-the-Bag Versus Ciliary Sulcus Secondary Intraocular Lens Implantation for Pediatric Aphakia: A Prospective Comparative Study

Liu

Jin

Tan

et al. 2022

American Journal of Ophthalmology

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“…Of these potentially relevant articles, 176 publications were excluded for various reasons, and 33 publications met the inclusion criteria and were included in this report. These comprised 3 RCTs [44][45][46][47][48][49][50][51][52][53][54][55][56][57][58][59][60][61] and 15 nonrandomized studies, [62][63][64][65][66][67][68][69][70][71][72][73][74][75][76] relevant to research questions 1, 2, 3, and 4. No economic evaluations relevant to research questions 5 and 6 were identified. There were 16 clinical publications and 1 methods publication (which was not included in the overall count) 77 that reported on the same RCT -the Infant Aphakia Treatment Study (IATS).…”

Section: Quantity Of Research Availablementioning

confidence: 99%

Intraocular Lenses for Infants With Aphakia

Team¹

2022

cjht

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This systematic review examined intraocular lens implantation in patients aged 12 months or younger at the time of surgery compared with patients aged 12 months or younger with aphakia treated with contact lenses or glasses. It also examined intraocular lens implantation in patients aged 12 months or younger at the time of surgery (i.e., infants) compared with patients older than 12 months up to 12 years of age at the time of surgery (i.e., children). In total, 18 studies (3 randomized controlled trials and 15 nonrandomized studies) were identified that answered the clinical questions relevant to this review. No relevant studies were identified to inform the cost-effectiveness questions. Visual outcomes (i.e., visual acuity) did not seem to differ between patients aged 12 months or younger at the time of surgery who received intraocular lens implantation and in patients with aphakia treated with contact lenses or glasses. Parenting stress was higher in parents of infants who received intraocular lens implantation at 3 months after surgery compared with parents of infants who were treated with contact lenses; however, this difference was not maintained at 1 year after surgery. In 1 study that examined intraocular lens implantation at different ages, age did not appear to be a significant prognostic factor in poor visual outcomes (i.e., visual acuity defined as > 0.5 logMAR). Regarding safety, infants who underwent intraocular lens implantation experienced more frequent occurrences of complications, such as visual axis opacification, compared with infants with aphakia treated with contact lenses or glasses; therefore, more reoperations to remove the opacification were required. Many infants with aphakia who did not receive intraocular lens implantation eventually required the surgery when they got older. There were limited statistical comparisons available for safety outcomes for intraocular lens implantation in infants at different ages. Overall, the incidence in adverse events was similar between infants and children, except for the number of additional surgeries. In the identified literature, younger patients received more additional surgeries than older patients. The risk of bias in the included studies was high. There were many methodological concerns, including selection bias, reporting issues, statistical issues, and study designs with high risk of bias, such as retrospective cohort studies. Family input regarding patients’ and caregivers’ experiences included reports of stress related to the use of contact lenses and stress about outcomes of the cataract removal and/or intraocular lens implantation and the effect on the child, and emphasized timely treatment to ensure optimal development of the child.

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“…Several studies have shown that the younger the age at the time of surgery the higher the risk for secondary glaucoma. 4 –6…”

Section: Introductionmentioning

confidence: 99%

Clinical characteristics and treatment of secondary glaucoma, glaucoma suspects and ocular hypertension after congenital cataract surgery

Eibenberger

Kiss

Schmidt‐Erfurth

et al. 2021

European Journal of Ophthalmology

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Objective: To evaluate changes in intraocular pressure after congenital cataract surgery in a real-world setting. Methods: This retrospective case series included all children aged 0–2 years undergoing lens extraction due to congenital cataract. Development of an elevated intraocular pressure was divided into three groups: secG, suspG and OHT. Further, risk factors for IOP changes, the therapeutic approach and functional outcome were assessed during follow-up. Results: One hundred and sixty-one eyes of 110 patients aged 0–2 years were included, whereof 29 eyes of 17 children developed secondary glaucoma (secG; 11 eyes/8 patients), glaucoma suspect (suspG; three eyes/three patients) or ocular hypertension (OHT; 15 eyes/10 patients). No difference in surgrical procedure ( p = 0.62) was found, but age at cataract surgery differed significantly ( p = 0.048), with the secG group (1.74 ± 1.01 months) being the youngest (suspG: 3.93 ± 1.80 months; OHT group: 5.91 ± 5.36 months). Secondary surgical intervention was significantly higher in the secG (4.64 ± 3.41) followed by the suspG (2.00 ± 2.65) and OHT groups (0.40 ± 0.74; p < 0.001). Postoperative complications including nystagmus ( p = 0.81), strabismus ( p = 0.98) and amblyopia ( p = 0.73) showed no difference, in contrast to visual axis obscuration which was more common in the secG group ( p = 0.036). Conclusion: Initial lensectomy and anterior vitrectomy procedure together with or without IOL implantation seems to have no influence for the development of IOP changes after pediatric cataract surgery. However, children who developed secondary glaucoma had cataract surgery significantly earlier, within the first 2–3 months of life. Glaucoma surgery was required to achieve final IOP control in most eyes. The development of secondary glaucoma was also associated with a significant increase in surgical re-treatments.

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Glaucoma following cataract surgery in the first 2 years of life: frequency, risk factors and outcomes from IoLunder2

Cited by 26 publications

References 27 publications

In-the-Bag Versus Ciliary Sulcus Secondary Intraocular Lens Implantation for Pediatric Aphakia: A Prospective Comparative Study

In-the-Bag Versus Ciliary Sulcus Secondary Intraocular Lens Implantation for Pediatric Aphakia: A Prospective Comparative Study

Intraocular Lenses for Infants With Aphakia

Clinical characteristics and treatment of secondary glaucoma, glaucoma suspects and ocular hypertension after congenital cataract surgery

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