Glaucoma-TrEl: A web-based interactive database to build evidence-based hypotheses on the role of trace elements in glaucoma

Choudhari, Jyoti Kant; Eberhardt, Martin; Chatterjee, Tanushree; Hohberger, Bettina; Vera, Julio

doi:10.1186/s13104-022-06210-0

Cited by 4 publications

(2 citation statements)

References 55 publications

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“…One way to approach this is by using computational tools to analyse large databases and generate evidence-based hypotheses on the impact of important elements in digestive, bone, and skin disorders. This can help guide further experimental research in these areas [53].…”

Section: Discussionmentioning

confidence: 96%

Incipient Salinization: A Case Study of the Spring of Asclepieion in Lentas (Ancient Lebena), Crete

Manoutsoglou,

Bei

2024

Geosciences

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Sanctuaries devoted to Asclepius were established and operated for almost a thousand years in various Greek and Roman cities throughout the Mediterranean region. The Asclepieion sanctuary in Lentas (formerly known as Ancient Lebena) in Crete was famous for receiving water from a sacred spring. In Ancient Lebena, Levinaion was a famous centre for hydrotherapy, physiotherapy, and a psychiatric hospital. In the present paper, we aim to assess the hydrochemical status of this sacred spring that holds a prominent position in archaeological and historical studies. The main objectives of this study are: Initially, to present supervisory evidence (archaeological, geological, hydrochemical) of an area that was a water resource management model for many centuries, carrying out therapeutic work. The second objective is to present and compare hydrochemical data in the last century, i.e., from 1915 to 2021. The third objective is to highlight and warn of an incipient saltwater intrusion in the area along the Lentas coast. The fourth objective is to propose an alternative and sustainable form of water resources management in the region that requires the study and rational utilization of the sporadic small water springs in the region. Our study focuses on a basic hydrochemical analysis of spring and borehole water in the remains of Levinaion in the Lentas region, and their comparison with sparse historical data of the sacred spring water, aiming to interpret the impact of the changes in the spring water resources that occurred in recent decades due to urban modernization. Our results highlight (i) visible fluctuations in chemical composition of borehole water samples; (ii) a neutral to alkaline pH in borehole waters and an alkaline pH in spring waters; (iii) undetectable arsenic in Lentas borehole water, unlike historical data of Lentas spring water; (iv) low values of dissolved radon in Lentas borehole water and the spring water of Kefalovrysa; and (v) a timeless constant and hypothermic nature of the water of both the sacred spring and borehole of Lentas, and also of the Kefalovrysa spring. The recorded historical data, i.e., from 1915 to 1957, due to the absence of substantial anthropogenic activity in the area, can be used as reference values (natural background levels, NBLs) for the Lentas area. Our findings emerge with the need to bring again the flowing spring water of the sacred spring of Lentas in its original form through sustainable management and re-discover its beneficial therapeutical effects.

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Section: Discussionmentioning

confidence: 96%

Incipient Salinization: A Case Study of the Spring of Asclepieion in Lentas (Ancient Lebena), Crete

Manoutsoglou,

Bei

2024

Geosciences

View full text Add to dashboard Cite

show abstract

“…One way to approach this is by using computational tools to analyze large databases and generate evidence-based hypotheses on the impact of important elements in digestive, bone, and skin disorders. This can help guide further experimental research in these areas [53].…”

Section: Discussionmentioning

confidence: 96%

Incipient Salinaziation: A Case Study in the Spring of Asclepieion of Lentas (Ancient Lebena), Crete

Manoutsoglou,

Bei

2024

Preprint

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Sanctuaries devoted to Asclepius were established and operated for almost a thousand years in various Greek and Roman cities throughout the Mediterranean region. The Asclepieion sanctuary in Lenta (formerly known as Ancient Lebena) in Crete was famous for receiving water from a sacred spring. In the Ancient Lebena, Levinaion was a famous centre for hydrotherapy, physiotherapy and a psychiatric hospital. In the present paper, we aim to assess the hydrochemical status of this sacred spring that holds a prominent position in archaeological and historical studies. The main objectives of this study are: Initially, to present supervisory evidence (archaeological, geological, hydrochemical) of an area that was a water resource management model for many centuries, carrying out therapeutic work. The second objective is to present and compare hydrochemical data in the last century, i.e. from 1915 to 2021. The third objective is to highlight and warn of an incipient saltwater intrusion in the area along the Lentas coast. The fourth objective is to propose an alternative and sustainable form of water resources management in the region that requires the study and rational utilization of the sporadic small water springs in the region. Our study focuses on a basic hydrochemical analysis of spring and borehole water in the remains of Levinaion in the Lentas region and their comparison with spare historical data of the sacred spring water, aiming to interpret the impact of the changes in the spring water resources that occurred in the last decades due to urban modernization. Our results highlight (i) visible fluctuations in chemical composition of borehole water samples, (ii) a neutral to alkaline pH in borehole waters, and an alkaline pH in spring waters, (iii) un-detectable arsenic of Lentas borehole water, unlike historical data of Lentas spring water, (iv) low values of dissolved radon of Lentas borehole water and spring water of Kefalovrysa, and (v) a timeless constant and hypothermic nature of the water of both sacred spring and borehole of Lenta, but also of Kefalovrysa spring. The recorded historical data, i.e. from 1915 to 1957, due to the absence of substantial anthropogenic activity in the area, can be used as reference values (natural background levels, NBLs) for the Lentas area. Our findings emerge with the need to bring again the flowing spring water of the sacred spring of Lentas in its original form through sustainable management and re-discover its beneficial therapeutical effects.

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TraceEyeDisease: a web-based database for investigating trace elements and their imbalances in eye diseases

Choudhari,

Yadav,

Chouhan

2024

BMC Res Notes

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Eye diseases remain a significant global health concern, with trace elements crucial in maintaining ocular health and preventing ocular disorders. In ocular health, trace elements have been recognized as critical factors influencing the development and progression of multiple eye diseases. In this study, we conducted a thorough literature search through PubMed to acquire data concerning different eye diseases associated with trace elements. These diseases are essential in trace element imbalances or deficiencies in their progression. Our approach included a meticulous compilation of information from various databases, systematically integrated into a carefully curated database. In total, we identified 178 distinct genes that encode proteins linked to fourteen trace elements in this comprehensive list. A web-based database designed to formulate evidence-based hypotheses regarding the impact of trace element deficiency and imbalance on eye diseases was presented using Shiny R. This study underscores the vital role of trace elements in preserving ocular health. The Shiny R application facilitates subsequent investigations, fostering enhanced insights into public health, clinical practices, and eye disease research. The URL of TraceEyeDiseas is https://tredis.shinyapps.io/TraceEyeDisease/ .

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Glaucoma-TrEl: A web-based interactive database to build evidence-based hypotheses on the role of trace elements in glaucoma

Cited by 4 publications

References 55 publications

Incipient Salinization: A Case Study of the Spring of Asclepieion in Lentas (Ancient Lebena), Crete

Incipient Salinization: A Case Study of the Spring of Asclepieion in Lentas (Ancient Lebena), Crete

Incipient Salinaziation: A Case Study in the Spring of Asclepieion of Lentas (Ancient Lebena), Crete

TraceEyeDisease: a web-based database for investigating trace elements and their imbalances in eye diseases

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