Glaucoma Workup in Congenital Zika Syndrome

Oliveira, Daniela R. de; Ventura, Camila V.; Esporcatte, Bruno L. B.; Gracitelli, Carolina P. B.; Dias, Natalia de Carvalho; Ventura, Liana O.; Belfort, Rubens; Rolim-de-Moura, Christiane

doi:10.1097/ijg.0000000000001253

Cited by 3 publications

(8 citation statements)

References 7 publications

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“…The pregnant females were found to develop viremia. These data are suggestive of an ascending infection from the vaginal tissues to the uterus for fetal involvement [57].…”

Section: Sexual Transmission Murine Modelsmentioning

confidence: 87%

Current Concepts in Zika Research

Rodríguez‐Morales¹

2021

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Before 2013, yellow fever and dengue were the main arboviruses of concern in the Latin American region. However, after December of that year, chikungunya arrived in the region, and a couple of years later Zika virus (ZIKV) [1][2][3][4][5][6][7][8][9][10][11][12][13][14][15][16]. Zika is another virus transmitted by vectors (arboviruses) affecting not only people living in the tropics, but also travelers and migrating populations [17][18][19][20]. Zika has impacted significantly on the health of the Americas, especially in Central and South America, due to the large number of cases of Guillain-Barré Syndrome that have been reported in the association, as well, especially due to microcephaly and the Congenital Zika Syndrome, which was the reason for it to be declared on February 2016 as a Public Health Emergency of International Concern (PHEIC) by the World Health Organization (WHO) [1][2][3][4][5][6][7][8][9][10][11][12][13][14][15][16].Keeping these issues in mind, this book includes different topics regarding research and clinical topics related to Zika virus research in the last five years in the Americas as well as in the World. This book has been organized in three major sections: Epidemiology; Clinical Aspects; and Zika and Guillain-Barré Syndrome.Commissioning of this book by IntechOpen editorial has been related in part to my long commitment to vector-borne, zoonotic, and neglected tropical diseases, being involved as Co-Chair of the Working Group on Zoonoses of the International Society for Chemotherapy (WGZ-ISC), as well as in Colombia at the Committee on Tropical Medicine, Zoonoses and Travel Medicine of the Colombian Association of Infectious Diseases (Asociación Colombiana de Infectología, ACIN) and more recently important, as the Chair of the Colombian Collaborative Network of Research on Zika (Red Colombiana de Colaboración en Zika) (RECOLZIKA), since January 2016. RECOLZIKA has contributed to multiple aspects of the research on Zika in Colombia and other countries in Latin America, including about the Congenital Zika Syndrome as well as on the Guillain-Barré, among other clinical consequences of this arboviral disease (more than 50 papers in journals indexed on Scopus, Web of Sciences and PubMed, among other databases).

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“…The pregnant females were found to develop viremia. These data are suggestive of an ascending infection from the vaginal tissues to the uterus for fetal involvement [57].…”

Section: Sexual Transmission Murine Modelsmentioning

confidence: 87%

Current Concepts in Zika Research

Rodríguez‐Morales¹

2021

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“…Optic nerve hypoplasia is one of the most important findings in infants with congenital Zika virus infection [51]. This condition can be identified with the double ring sign as a manifestation of a small and undeveloped optic nerve [23,52,56,57] (Figure 1). Other typical signs of insult to the optic nerve include pallor and increased cup-to-disk ratio [13,15,56,57] (Figure 2).…”

Section: Optic Nerve Findings and Macular Abnormalitiesmentioning

confidence: 99%

“…This condition can be identified with the double ring sign as a manifestation of a small and undeveloped optic nerve [23,52,56,57] (Figure 1). Other typical signs of insult to the optic nerve include pallor and increased cup-to-disk ratio [13,15,56,57] (Figure 2). The most frequent macular findings associated with congenital Zika virus infection include gross pigment mottling, foveal reflex loss and chorioretinal atrophy, which differs from toxoplasmosis scars because of the absence of intraocular inflammatory signs and the presentation of a typical dark pigmentation rim around the atrophic area [15,18,58].…”

Section: Optic Nerve Findings and Macular Abnormalitiesmentioning

confidence: 99%

“…This condition is rare (2.6%) but can occur in infants presenting with CZS and microcephaly. The related findings include and enlarged and cloudy cornea, buphthalmos, photophobia and excessive tearing [11,57,61].…”

Section: Congenital Glaucomamentioning

confidence: 99%

“…Glaucoma in Congenital Zika syndrome is a visual-threatening condition that need special attention and early treatment, were the use of hypotensive topical medications and surgery like trabeculotomy, trabeculectomy, trabeculotomy plus trabeculectomy or goniotomy are the most used strategies [13,21,57,61].…”

Section: Ocular Treatmentmentioning

confidence: 99%

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The Eye and the Zika Virus

Martínez-Pulgarín¹,

Córdoba-Ortega²,

Padilla-Pantoja³

2021

Current Concepts in Zika Research

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Ocular involvement in Zika virus (ZIKV) infection can be present both in adults and infants as acquired and congenital diseases respectively. Through experimental studies, there has been clarified important mechanisms of ocular pathogenesis that allow the establishment of potential objectives for antiviral drugs development. The spread of the virus at the ocular level could be hematogenous or axonal, however the hematogenous route through the choroid is suggested as the most important initial mechanism for infection. Ocular manifestations vary according to the age of presentation, being mild and self-limited in adults and potentially devastating in children, related to congenital Zika syndrome (CZS). Ocular diagnosis is made based in clinical features and contact/travel history to countries of epidemiological importance; fundoscopy, optical coherence tomography, fluoresceinic/green indocianine angiography, cultures, serological and molecular tests are useful diagnostic tools. Ocular management is focused according to the clinical context of each patient. Prevention is carried out in a comprehensive manner and further research is directed to vaccine development and specific antiviral treatment. Proper attention requires a multidisciplinary team in order to reach complete visual evaluation and early rehabilitation.

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Ocular findings of congenital Zika virus infection with microcephaly

Costa

Meira-Freitas

2022

Int Ophthalmol

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Glaucoma Workup in Congenital Zika Syndrome

Cited by 3 publications

References 7 publications

Current Concepts in Zika Research

Current Concepts in Zika Research

The Eye and the Zika Virus

Ocular findings of congenital Zika virus infection with microcephaly

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