The use of new generation wires in the design of wide spans of overhead power lines over water barriers and large gorges can increase their transmission capacity and increase reliability. However, when large currents flow, load losses in line also increase. Thus, it is necessary to obtain a methodology for technical and economic comparison of design options for overhead power lines over large crossings, which enables to determine the most cost-effective version of the project with high mechanical reliability. For comparative analysis, five options for wide spans of overhead power lines over the river with new-generation wires of Russian production were compiled: Aluminium Alloy Conductor Steel Reinforced, Z-type (high conductivity), Thermal-Resistant Conductor, Aluminium Compozite Core Conductor, ASk2y. Option with Aluminium Conductor Steel Reinforced wire was taken as the source. For the first option, the crossing scheme E-A-A-E was selected, for the remaining options E-I-I-E scheme was considered. For the modes of maximum loads, minimum temperature and average annual conditions, the mechanical calculation of wires was carried out using the method of permissible stresses. The wire bending deflections were determined in accordance with the theory of the catenary curve. The method of integrated indicators was used to perform a technical and economic comparison of these options. The calculation results showed that among the proposed options, the most optimal is a crossing with the ACCC wire having minimum relative investment per 1 MW of transmitted electricity and minimal power loss. The transmission capacity of the line with this wire is increased by 1.8 times, and the cost of crossing is reduced by 16%. Due to the compact design of wire, the probability of ice formation on wire is reduced, and the reduced bending deflection reduces the probability of wire break due to natural environmental influences.