1971
DOI: 10.1002/jps.2600600717
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GLC Analysis of Multicomponent Suppository Formulations

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1972
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Cited by 5 publications
(2 citation statements)
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“…Previous studies established the need for assay methods that are sufficiently sensitive to measure -2 ng of drug/ml of serum (1,2), a fact that contributed to the paucity of pharmacokinetic data. Although several analytical procedures are available to measure chlorpheniramine (1,2,(5)(6)(7)(8)(9)(10), most of the methods were developed to assay the drug in dosage forms or in urine; only a few of these methods have the necessary sensitivity to measure normal serum levels throughout a kinetic investigation.…”
Section: Introductionmentioning
confidence: 99%
“…Previous studies established the need for assay methods that are sufficiently sensitive to measure -2 ng of drug/ml of serum (1,2), a fact that contributed to the paucity of pharmacokinetic data. Although several analytical procedures are available to measure chlorpheniramine (1,2,(5)(6)(7)(8)(9)(10), most of the methods were developed to assay the drug in dosage forms or in urine; only a few of these methods have the necessary sensitivity to measure normal serum levels throughout a kinetic investigation.…”
Section: Introductionmentioning
confidence: 99%
“…Cometti and coworkers (54) recently reported on gas chromatographic analysis of multicomponent suppositories. Depending on the composition of the vehicle, absolute ethanol, chloroform or a mixture of chloroform and alcohol-containing internal standards is added to the melted suppository to dissolve the sample.…”
mentioning
confidence: 99%