GLC Determination of dl-2-(3-Phenoxyphenyl)propionic Acid (Fenoprofen) in Human Plasma

Nash, J.F.; Bopp, Ronald J.; Rubin, Alan

doi:10.1002/jps.2600600713

Cited by 16 publications

(3 citation statements)

References 2 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Fenoprofen concentrations in plasma were measured by GLC analysis of hexane extracts of deproteinized plasma (Nash, Bopp & Rubin, 1971 & Gruber, 1972a, Rubin, Warrick, Wolen, Chernish, Ridolfo & Gruber, 1972b The rats were separated randomly into two groups of 40 rats each: the control group was pretreated with 0.9% w/v NaCl (physiological saline; 10 ml/kg i.p.) once daily for six days, the drug group received 50 mg/kg of phenobarbitone in 10 ml of solution/kg i.p.…”

Section: Methodsmentioning

confidence: 99%

“…Fenoprofen concentrations in plasma were measured by GLC analysis of hexane extracts of deproteinized plasma (Nash, Bopp & Rubin, 1971); total [14C] -fenoprofen equivalents and non-metabolized fenoprofen were assayed in urine, Present address: Department of Pharmacology, University of Copenhagen, 20 Juliane Mariesvej, DK-2100 Copenhagen, Denmark. and in hexane extracts of urine, respectively, by liquid scintillation spectroscopy (Rubin, Rodda, Warrick, Ridolfo & Gruber, 1972a, Rubin, Warrick, Wolen, Chernish, Ridolfo & Gruber, 1972b.…”

Section: Methodsmentioning

confidence: 99%

See 1 more Smart Citation

A Pharmacokinetic Interaction in Man Between Phenobarbitone and Fenoprofen, a New Anti‐inflammatory Agent

Helleberg

Rubin

Wolen

et al. 1974

Brit J Clinical Pharma

Self Cite

View full text Add to dashboard Cite

1The effect of repeated administration of phenobarbitone on the plasma disposition of fenoprofen (±-243-phenoxyphenyl) propionic acid) was investigated in rats and man.2 The plasma elimination rate constants increased significantly and the rats excreted proportionately more metabolized fenoprofen in the urine. These findings are consistent with an increase in the rate of metabolism of fenoprofen. 3 This interaction between phenobarbitone (and presumably other inducers of drug metabolizing enzymes) and fenoprofen should be considered when evaluating the clinical usefulness of fenoprofen.

show abstract

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

A Pharmacokinetic Interaction in Man Between Phenobarbitone and Fenoprofen, a New Anti‐inflammatory Agent

Helleberg

Rubin

Wolen

et al. 1974

Brit J Clinical Pharma

Self Cite

View full text Add to dashboard Cite

show abstract

“…aliquots of deproteinized plasma as the trimethylsilyl ester using the GLC method of Nash et al (2). Fenoprofen in plasma-Fenoprofen content was measured in hexane extracts of 1-ml.…”

mentioning

confidence: 99%

Physiological Disposition of Fenoprofen in Man II: Plasma and Urine Pharmacokinetics after Oral and Intravenous Administration

Rubin

Rodda

Warrick

et al. 1972

Journal of Pharmaceutical Sciences

View full text Add to dashboard Cite

Fenoprofen ®calcium in rheumatoid arthritis. a controlled double‐blind crossover evaluation

Fries¹,

Britton²

1973

Arthritis & Rheumatism

View full text Add to dashboard Cite

Fenoprofen Calcium (Lilly, Compound 69323) is a new nonsteroidal analgesic and antiinflammatory drug proposed for the treatment of rheumatoid arthritis and allied conditions. In a controlled double‐blind crossover study comparing 6 weeks of Fenoprofen therapy with 6 weeks of treatment with high‐dose acetylsalicylic acid, the aspirin proved minimally more effective and substantially more toxic. Nine of 27 patients found Fenoprofen equal to aspirin, and 6 preferred it. Twelve patients preferred aspirin. The safety of the drug suggested by animal studies appears to be confirmed by these short‐term studies in relatively small numbers of patients. It appears likely that Fenoprofen will provide a useful, although not dramatic, additional agent with which to manage the patient with rheumatoid arthritis.

show abstract

GLC Determination of dl-2-(3-Phenoxyphenyl)propionic Acid (Fenoprofen) in Human Plasma

Cited by 16 publications

References 2 publications

A Pharmacokinetic Interaction in Man Between Phenobarbitone and Fenoprofen, a New Anti‐inflammatory Agent

A Pharmacokinetic Interaction in Man Between Phenobarbitone and Fenoprofen, a New Anti‐inflammatory Agent

Physiological Disposition of Fenoprofen in Man II: Plasma and Urine Pharmacokinetics after Oral and Intravenous Administration

Fenoprofen ®calcium in rheumatoid arthritis. a controlled double‐blind crossover evaluation

Contact Info

Product

Resources

About