2019
DOI: 10.1126/science.aay6144
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Glia in the skin activate pain responses

Abstract: A newly discovered cell type forms a network that senses painful stimuli

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Cited by 12 publications
(8 citation statements)
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“…Although only reported in mice until now, the recently discovered (50) specialized cutaneous Schwann cells with extensive processes forming a mesh-like network in the subepidermal border of the skin that conveys noxious thermal to the nerve endings might be also involved in the occurrence of sensitive skin syndrome (41). Schwann cells in the skin can activate pain responses (51).…”
Section: Pathophysiologymentioning
confidence: 99%
“…Although only reported in mice until now, the recently discovered (50) specialized cutaneous Schwann cells with extensive processes forming a mesh-like network in the subepidermal border of the skin that conveys noxious thermal to the nerve endings might be also involved in the occurrence of sensitive skin syndrome (41). Schwann cells in the skin can activate pain responses (51).…”
Section: Pathophysiologymentioning
confidence: 99%
“…The association between PPS and the autonomic warning and defense system is the key to the understanding of the present concept of changes in PPS reflecting changes in sensitivity of the autonomic warning and defense system regulation by the regulatory center of the stress response, i.e., the hypothalamus. Pressure pain perception at the periosteal bone depends on activation of nociceptive neurons, i.e., terminals of myelinated A-delta and unmyelinated C-fiber neurons (Nencini and Ivanusic, 2016; Figures 5A-G), and perhaps also of glial cells of the dermis (Abdo et al, 2019;Doan and Monk, 2019).…”
Section: Pressure Pain Sensitivity As Measure Of Cerebral Autonomic Functionmentioning
confidence: 99%
“…The Tinel sign and sensory collapse test can be used as clinical provocative tests to assist with diagnoses. 20 , 34 , 36 In this paper, we have attempted to provide a conceptual framework to practically think about neuralgia. Notably, we have not specifically addressed chronic regional pain syndrome, injury from nerve blocks, needle sticks, injection injuries, and neuralgia amyotrophy (Parsonage Turner syndrome); all are beyond the scope of this article.…”
Section: Discussionmentioning
confidence: 99%
“…We hypothesize that damage to the peripheral first-order neurons, along with spontaneously firing second-order neurons (deafferentation), causes this pain and, if not treated in a timely manner, results in cortical remodeling and centrally mediated pain (as in phantom limb pain). 20 , 25 , 36 Often described as unpleasant, difficult to describe, cold, or numbing pain, it is constant, with fluctuating severity, but is not reproducible by palpation or examination. Physicians can easily dismiss this pain if not understood or, worse, attempt to treat it surgically with repeated neuroma surgery.…”
Section: Phantom Nerve Pain (Anesthesia Dolorosa or Deafferentation P...mentioning
confidence: 99%