2023
DOI: 10.1152/ajpheart.00332.2022
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Glial cell activity in cardiovascular diseases and risk of acute myocardial infarction

Abstract: Growing evidence indicates that the pathophysiological link between the brain and heart underlies cardiovascular diseases, specifically acute myocardial infarction (AMI). Astrocytes are the most abundant glial cells in the central nervous system and provide support/protection for neurons. Astrocytes and peripheral glial cells are emerging as key modulators of the brain-heart axis in AMI, by affecting sympathetic nervous system activity (centrally and peripherally). This review therefore aimed to gain an improv… Show more

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Cited by 6 publications
(3 citation statements)
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“…It has been widely accepted that neuroinflammationmediated sympathetic regulatory center dysfunction is involved in sympathetic hyperactivation in cardiovascular diseases [79][80][81]. Our previous studies revealed that neuroinflammation induced by microglia activation is involved in the increase of sympathetic output [70,71,82].…”
Section: Discussionmentioning
confidence: 93%
“…It has been widely accepted that neuroinflammationmediated sympathetic regulatory center dysfunction is involved in sympathetic hyperactivation in cardiovascular diseases [79][80][81]. Our previous studies revealed that neuroinflammation induced by microglia activation is involved in the increase of sympathetic output [70,71,82].…”
Section: Discussionmentioning
confidence: 93%
“…They have predictive value for predicting outcomes in various clinical conditions, measured against radiological criteria, clinical status or functional outcomes. The role of glial cells in the development of cardiovascular disease has also been raised, pointing to disorders of the brain-heart axis, where astrocytes and peripheral glial cells are key modulators, affecting sympathetic nervous system activity (central and peripheral [75]).…”
Section: Discussionmentioning
confidence: 99%
“…Characterization of the complex phenomena underlying the functional relationship between the central nervous system (CNS) and autonomic nervous system (ANS) has increasingly gained attention in the last decade. Although initially believed to pertain solely to central control over peripheral organs, the phenomenon is multi‐faceted and can be studied at different scales, from neural and glial signaling (Marina et al, 2016 ; Truter et al, 2023 ) to functional psychosomatic reverberations (Candia‐Rivera, Catrambone, Thayer, et al, 2022 ; Skora et al, 2022 ).…”
Section: Introductionmentioning
confidence: 99%