Glial cell line-derived neurotrophic factor (GDNF) in blood serum and lacrimal fluid of patients with a current depressive episode

Zinchuk, Mikhail; Guekht, Alla; Дружкова, Т. А.; Gulyaeva, N. V.; Shpak, A.A.

doi:10.1016/j.jad.2022.09.025

Cited by 13 publications

(6 citation statements)

References 32 publications

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“…Importantly, in our study, GDNF in LF was significantly reduced in FE, FE + MDD, and MDD. Our recent study found that the changes in GDNF in LF of patients with bipolar disorder and MDD [16] were similar to those found in FE and in FE + MDD in the present study. However, in the present study, depression did not influence the GDNF content either in LF or BS.…”

Section: Neurotrophic Factors In Epilepsysupporting

confidence: 90%

“…Particularly, in patients with focal epilepsy, CNTF levels were increased, while BDNF levels decreased both in the blood serum (BS) and LF, suggesting that high CNTF levels and low BDNF levels in the LF could be considered as non-invasive biomarkers of focal epilepsy [14,15]. Lacrimal GDNF levels were assessed in patients with bipolar disorder and major depressive disease (MDD), and it was shown that a low GDNF concentration in LF could be a potential biomarker of depression [16].…”

Section: Of 18mentioning

confidence: 99%

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Reduced Levels of Lacrimal Glial Cell Line-Derived Neurotrophic Factor (GDNF) in Patients with Focal Epilepsy and Focal Epilepsy with Comorbid Depression: A Biomarker Candidate

Shpak,

Rider,

Druzhkova

et al. 2023

IJMS

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Our previous studies showed that in patients with brain diseases, neurotrophic factors in lacrimal fluid (LF) may change more prominently than in blood serum (BS). Since glial cell line-derived neurotrophic factor (GDNF) is involved in the control of neuronal networks in an epileptic brain, we aimed to assess the GDNF levels in LF and BS as well as the BDNF and the hypothalamic–pituitary–adrenocortical and inflammation indices in BS of patients with focal epilepsy (FE) and epilepsy and comorbid depression (FE + MDD) and to compare them with those of patients with major depressive disorder (MDD) and healthy controls (HC). GDNF levels in BS were similar in patients and HC and higher in FE taking valproates. GDNF levels in LF were significantly lower in all patient groups compared to controls, and independent of drugs used. GDNF concentrations in LF and BS positively correlated in HC, but not in patient groups. BDNF level was lower in BS of patients compared with HC and higher in FE + MDD taking valproates. A reduction in the GDNF level in LF might be an important biomarker of FE. Logistic regression models demonstrated that the probability of FE can be evaluated using GDNF in LF and BDNF in BS; that of MDD using GDNF in LF and cortisol and TNF-α in BS; and that of epilepsy with MDD using GDNF in LF and TNF-α and BDNF in BS.

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Section: Neurotrophic Factors In Epilepsysupporting

confidence: 90%

Section: Of 18mentioning

confidence: 99%

Reduced Levels of Lacrimal Glial Cell Line-Derived Neurotrophic Factor (GDNF) in Patients with Focal Epilepsy and Focal Epilepsy with Comorbid Depression: A Biomarker Candidate

Shpak,

Rider,

Druzhkova

et al. 2023

IJMS

Self Cite

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“…C-Reactive Protein, Interleukin-6 (IL-6), IL-1ß, Tumor Necrosis Factor-α (TNFα) are considered to be common markers of inflammation ( 9 , 10 ). Neurotrophic factor family:brain-derived neurotrophic (BDNF) and Glial cell line-derived neurotrophic factor (GDNF) ( 11 , 12 )，as well as oxidative stress ( 13 ) and mitochondrial metabolism-related products ( 14 ) are also potential biomarkers of MDD. Although many candidate metabolite indicators associated with depression and drug response have been identified, few of them have been validated in larger population-based cohorts, and thus there are still no biomarkers that can be applied to the clinical diagnosis and treatment of depression.…”

Section: Introductionmentioning

confidence: 99%

The roles of extracellular vesicles in major depressive disorder

et al. 2023

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Major depressive disorder (MDD) is a serious mental disease characterized by depressed mood, loss of interest and suicidal ideation. Its rising prevalence has rendered MDD one of the largest contributors to the global disease burden. However, its pathophysiological mechanism is still unclear, and reliable biomarkers are lacking. Extracellular vesicles (EVs) are widely considered important mediators of intercellular communication, playing an important role in many physiological and pathological processes. Most preclinical studies focus on the related proteins and microRNAs in EVs, which can regulate energy metabolism, neurogenesis, neuro-inflammation and other pathophysiological processes in the development of MDD. The purpose of this review is to describe the current research progress of EVs in MDD and highlight their potential roles as biomarkers, therapeutic indicators and drug delivery carriers for the treatment of MDD.

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“…Interestingly, glial cells contain their own neurotrophic factor, referred to as glial cell line derived neurotrophic factor (GDNF), a class of proteins that also provide trophic support to neuronal cells including DAergic neurons [161]. Indeed, it has been proposed that lacrimal GDNF may serve as a marker in MDD [162]. Astrocytes also express high level of glial fibrillary astrocytic protein (GFAP) which are commonly used as a marker for their identification.…”

Section: Astroglia (Astrocytes)mentioning

confidence: 99%

Role of Glial Cells in Depression and Drug Addiction

Tizabi,

Getachew,

Hauser

et al. 2024

Preprint

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Major depressive disorder (MDD) and substance use disorder (SUD) are of immense medical and social concerns. Although significant progress on neuronal involvement in mood and reward circuitries has been achieved, only relatively recently the role of glia in these disorders have attracted attention. Detail understanding of the glial function in these devastating diseases could offer novel interventions. Here, following a brief review of circuitries involved in mood regulation and reward perception, specific contribution of the neurotrophic factors, neuroinflammation and gut microbiota to these diseases are highlighted. In this context, the role of specific glial cells (e.g., microglia, astroglia, oligodendrocytes and synantocytes) on phenotypic manifestation of MDD or SUD are emphasized. In addition, potential use of this knowledge in developing novel therapeutics is touched upon.

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Glial cell line-derived neurotrophic factor (GDNF) in blood serum and lacrimal fluid of patients with a current depressive episode

Cited by 13 publications

References 32 publications

Reduced Levels of Lacrimal Glial Cell Line-Derived Neurotrophic Factor (GDNF) in Patients with Focal Epilepsy and Focal Epilepsy with Comorbid Depression: A Biomarker Candidate

Reduced Levels of Lacrimal Glial Cell Line-Derived Neurotrophic Factor (GDNF) in Patients with Focal Epilepsy and Focal Epilepsy with Comorbid Depression: A Biomarker Candidate

The roles of extracellular vesicles in major depressive disorder

Role of Glial Cells in Depression and Drug Addiction

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